Results 221 to 230 of about 79,386 (326)

Clinical risk phenotypes in diabetes and their associations with adverse cardiovascular events: A report from the Silesia Diabetes‐Heart Project

open access: yesDiabetic Medicine, Volume 43, Issue 1, January 2026.
Abstract Aims Diabetes is characterized by clinical heterogeneity. This study aimed to identify different clinical phenotypes of real‐world people with diabetes and to assess their associations with major adverse cardiovascular events (MACEs). Methods From a prospective Polish registry of people with diabetes, hierarchical cluster analysis was ...
Marta Mantovani   +13 more
wiley   +1 more source

Mechanism of cyanobacterial ferredoxin‐dependent flavin thioredoxin reductase reveals thiolate‐FAD charge transfer and catalytic asymmetry in a homodimer

open access: yesThe FEBS Journal, Volume 293, Issue 1, Page 96-112, January 2026.
Ferredoxin‐dependent flavin thioredoxin reductases (FFTRs) regenerate reduced thioredoxin, sustaining dithiol–disulfide exchange reactions that regulate protein activity in select organisms. In cyanobacterial FFTRs, we describe the formation of a thiolate–flavin charge transfer complex, asynchronous reduction of the two FAD cofactors within the ...
Martha Minjarez‐Saenz   +8 more
wiley   +1 more source

Further Insights Into Anticholinergic Action Informed by Japanese Anticholinergic Risk Scale

open access: yesGeriatrics &Gerontology International, Volume 26, Issue 1, January 2026.
ABSTRACT The increased anticholinergic burden caused by medications in older adults is one of the adverse drug reactions of particular concern, as it can exacerbate the onset of geriatric syndromes or induce cognitive dysfunction, and is also related to the issue of polypharmacy.
Masaki Mogi   +4 more
wiley   +1 more source

Albiflorin‐Mediated MAP2K1 Targeting and HIF‐1 Signaling Inhibition Contribute to the Therapeutic Efficacy in Hyperuricemia‐Associated Cognitive Impairment

open access: yesHuman Mutation, Volume 2026, Issue 1, 2026.
This study investigated the therapeutic effects and mechanisms of Paeonia suffruticosa fruit pod extract (EMP) and its main component albiflorin (AF) on hyperuricemia‐associated cognitive impairment (HUA‐CI). A HUA‐CI mouse model was established, with cognitive function evaluated via Morris water maze.
Huimin Xiao   +7 more
wiley   +1 more source

Xanthine oxidase inhibitor allopurinol preserves cardiac function after experimental malocclusion induced by occlusal disharmony in mice. [PDF]

open access: yesJ Physiol Sci
Mitsubayashi T   +13 more
europepmc   +1 more source

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