Results 81 to 90 of about 78,843 (311)
Antioxidant activity, xanthine oxidase inhibition and acute oral toxicity of Dillenia philippinensis Rolfe (Dilleniaceae) leaf extract. [PDF]
Journal of Pharmacy & Pharmacognosy Research, 2021 Context: Hyperuricemia is a metabolic syndrome characterized by a high serum uric acid level with an increased risk of gout, diabetes, cardiovascular and renal disease.
Sarah S. Ansari +3 more
doaj
Four New Acyclic Diterpenes From
Natural Product Communications, 2021 Four new acyclic diterpenes, siegetalises A-D ( 1-4 ), were isolated from the aerial parts of Siegesbeckia orientalis . Their chemical structures were elucidated by extensive analysis of high-resolution electrospray ionization mass spectrometry and ...
Do Thi Trang +7 more
doaj +1 more source
Glutaredoxin GRXS17 associates with the cytosolic iron-sulfur cluster assembly pathway [PDF]
, 2016 Cytosolic monothiol glutaredoxins (GRXs) are required in iron-sulfur (Fe-S) cluster delivery and iron sensing in yeast and mammals. In plants, it is unclear whether they have similar functions.
Cammue, Bruno PA +18 more
core +2 more sources
CK2α Deficiency Drives Myocardial Fibrosis via Desmin‐Induced Mitochondrial Dysfunction
Advanced Science, EarlyView.CK2α preserves mitochondrial homeostasis by phosphorylating Desmin to recruit Cryab, ensuring proper filament assembly. CK2α deficiency disrupts this interaction, causing mitochondrial dysfunction, metabolic shifts, bioenergetic failure, and oxidative stress—ultimately establishing a pro‐fibrotic environment that drives cardiac fibrosis.
Canjie Ma +12 more
wiley +1 more source
KHẢO SÁT KHẢ NĂNG ỨC CHẾ ENZYME XANTHINE OXIDASE TỪ LÁ SA KÊ (ARTOCARPUS ALTILIS (PARK.) FOSB)
Tạp chí Khoa học Đại học Cần Thơ, 2014 Tăng acid uric không chỉ là nguyên nhân gây nên bệnh gout, mà còn làm tăng nguy cơ bệnh tim mạch, sỏi thận, đái tháo đường và các hội chứng chuyển hóa.
Đái Thị Xuân Trang +2 more
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In silico design and synthesis of targeted rutin derivatives as xanthine oxidase inhibitors
BMC Chemistry, 2019 Background Xanthine oxidase is an important enzyme of purine catabolism pathway and has been associated directly in pathogenesis of gout and indirectly in many pathological conditions like cancer, diabetes and metabolic syndrome.
Neelam Malik +2 more
doaj +1 more source
Alcohol drinking and mammary cancer: Pathogenesis and potential dietary preventive alternatives [PDF]
, 2014 Alcohol consumption is associated with an increased risk of breast cancer, increasing linearly even with a moderate consumption and irrespectively of the type of alcoholic beverage.
Castro, Gerardo Daniel +1 more
core +1 more source
Xanthine oxidase inhibitors and sepsis [PDF]
International Journal of Immunopathology and Pharmacology, 2018 Xanthine oxidase activation occurs in sepsis and results in the generation of uric acid (UrAc) and reactive oxygen species (ROS). We aimed to evaluate the effect of xanthine oxidase inhibitors (XOis) in rats stimulated with lipopolysaccharide (LPS). LPS (10 mg/kg) was administered intraperitoneally (i.p.) immediately after allopurinol (Alo, 2 mg/kg ...
Ramos, Maria Fátima de Paula +4 more
openaire +2 more sources
Animal Research and One Health, EarlyView.Myo‐inositol alleviates oxidative stress in dairy cow mammary epithelial cells via the Sirt5/Nrf2 pathway to promote mitochondrial fusion. This graphical abstract was created with BioRender.com. ABSTRACT High‐yielding dairy cows are susceptible to mammary gland oxidative stress due to prolonged intensive lactation, leading to redox imbalance.
Yufei Zhang +8 more
wiley +1 more source
Summer Savory (Satureja hortensis) Extract Inhibits Xanthine Oxidase [PDF]
Journal of Medicinal Plants and By-products, 2015 Xanthine oxidase plays crucial roles in the production of reactive oxygen species (ROS), and uric acid in blood which may lead to gout, one of the oldest known forms of arthritis amongst humans.
Yeganeh Teimoori-Boghsani +3 more
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