Results 111 to 120 of about 39,023 (141)

Self-assembly of N3-substituted xanthines in the solid state and at the solid-liquid interface.

Langmuir, 2013
The self-assembly of small molecular modules interacting through noncovalent forces is increasingly being used to generate functional structures and materials for electronic, catalytic, and biomedical applications.
A. Ciesielski, Sébastien Haar, A. Bényei, G. Paragi, C. F. Guerra, F. Bickelhaupt, F. Bickelhaupt, S. Masiero, J. Szolomajer, P. Samorí, G. Spada, L. Kovács   +11 more
semanticscholar   +1 more source

Novel 1,3-dipropyl-8-(3-benzimidazol-2-yl-methoxy-1-methylpyrazol-5-yl)xanthines as potent and selective A₂B adenosine receptor antagonists.

Journal of Medicinal Chemistry, 2012
Molecular modeling studies, including the comparative molecular field analysis (CoMFA) method, on 52 antagonists of the A(2B) adenosine receptor with known biological activity were performed to identify the three-dimensional features responsible for A(2B)
P. Baraldi, S. Baraldi, G. Saponaro, D. Preti, R. Romagnoli, L. Piccagli, A. Cavalli, M. Recanatini, A. Moorman, A. Zaid, K. Varani, P. Borea, M. Tabrizi   +12 more
semanticscholar   +1 more source

Double C-H activation: the palladium-catalyzed direct C-arylation of xanthines with arenes.

Organic Letters, 2011
The novel Pd-catalyzed C(sp(2))-H/C(sp(2))-H cross-coupling of unactivated xanthines with unactivated arenes utilizing a combination of Ag(I) and O(2) as oxidants exclusively yields C-8 arylated xanthines in a single synthetic operation.
C. Malakar, D. Schmidt, J. Conrad, U. Beifuss   +3 more
semanticscholar   +1 more source

3-Substituted xanthines as promising candidates for quadruplex formation: Computational, synthetic and analytical studies

, 2011
Our computational studies suggest that 3-substituted xanthines are good candidates for tetrad and quadruplex structures. 3-Methylxanthine (3MX) has been synthesized from 7-benzylxanthine, and the existence of tetrameric and octameric aggregates of 3MX ...
J. Szolomajer, G. Paragi, G. Batta, C. F. Guerra, F. Bickelhaupt, Z. Kele, P. Pádár, Z. Kupihar, L. Kovács   +8 more
semanticscholar   +1 more source

Development of new fluorescent xanthines as kinase inhibitors.

Organic Letters, 2010
An efficient and versatile synthetic approach for the preparation of highly substituted xanthine derivatives has been developed by a combination of direct N7- and C8-arylation.
Donghee Kim, H. Jun, Hyunseung Lee, Soon-Sun Hong, Sungwoo Hong   +4 more
semanticscholar   +1 more source

8-cyclopentyl-1,3-dipropylxanthine and other xanthines differentially bind to the wild-type and delta F508 first nucleotide binding fold (NBF-1) domains of the cystic fibrosis transmembrane conductance regulator.

Biochemistry, 1997
Cystic fibrosis is an autosomal recessive disorder affecting chloride transport in pancreas, lung, and other tissues, which is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR).
Cohen Be, George Lee, Kenneth A Jacobson, Kim Yc, Zhen Huang, Sorscher Ej, Harvey B. Pollard   +6 more
semanticscholar   +1 more source

Gold- and Silver-Catalyzed Intramolecular Hydroamination of Terminal Alkynes: Water-Triggered Chemo- and Regioselective Synthesis of Fused Tricyclic Xanthines

, 2009
A simple, convenient and green synthetic approach to diverse fused tricyclic xanthines has been developed via gold(I) complex-catalyzed intramolecular hydroamination or silver(I)-catalyzed isomerization-hydroamination of terminal alkynes under microwave ...
Deju Ye, Xu Zhang, Yu Zhou, Dengyou Zhang, Lei Zhang, Hengshuai Wang, Hualiang Jiang, Hong Liu   +7 more
semanticscholar   +1 more source

Synthesis of paraxanthine analogs (1,7-disubstituted xanthines) and other xanthines unsubstituted at the 3-position: structure-activity relationships at adenosine receptors.

Journal of Medicinal Chemistry, 1993
Synthetic procedures for the preparation of various 3-unsubstituted xanthines, including paraxanthine analogs (1,7-disubstituted xanthines) and 1,8-disubstituted xanthines, were developed.
C. Müller, D. Shi, Malcolm Manning, J. Daly   +3 more
semanticscholar   +1 more source

Fast determination of catechins and xanthines in tea beverages by micellar electrokinetic chromatography.

Journal of Agricultural and Food Chemistry, 2003
Antioxidant properties and stimulating effects of green tea are related to its content of cathechins and xanthines; tea quality evaluation is based on organoleptic tests and on the presence of those components.
M. Bonoli, Piero Colabufalo, M. Pelillo, T. Gallina Toschi, G. Lercker   +4 more
semanticscholar   +1 more source

Novel 1,3-disubstituted 8-(1-benzyl-1H-pyrazol-4-yl) xanthines: high affinity and selective A2B adenosine receptor antagonists.

Journal of Medicinal Chemistry, 2006
Adenosine has been suggested to induce bronchial hyperresponsiveness in asthmatics, which is believed to be an A(2B) adenosine receptor (AdoR) mediated pathway.
Rao V Kalla, E. Elzein, Thao D Perry, Xiaofen Li, V. Palle, V. Varkhedkar, A. Gimbel, Tennig Maa, D. Zeng, J. Zablocki   +9 more
semanticscholar   +1 more source