Results 131 to 140 of about 4,011 (296)
A deeper insight into the oxidative mechanism of caffeine and related xanthines: may caffeine be considered as an antioxidant? [PDF]
, 2017 Caffeine (CAF) is present in many consumer products as coffee, tea, chocolate, soft and energy drinks, resulting the most widely consumed psychoactive substance in human dietary. Many of its physiological effects are well known.
Curulli, A., Petrucci, R., Marrosu, G.
core
Alimentary Pharmacology &Therapeutics, EarlyView.In a retrospective population‐based cohort study using the University of Manitoba IBD Epidemiology Database, persons with IBD have an increased risk of ESRD by nearly 50%, with CD showing greater risk than UC. Bowel surgery, allopurinol use and oral steroid therapy are important predictors, emphasising the necessity of careful renal monitoring in IBD ...
Onuma Sattayalertyanyong +4 more
wiley +1 more source
Métodos para análise de ácido clorogênico
Química Nova, 2004 This paper describes the analytical methods for determination of total chlorogenic acid (CGA) and their individual isomers. Spectrofotometric methods are adequate for total CGA analysis in green coffee but they can provide inflated results for coffee ...
De Maria Carlos Alberto Bastos +1 more
doaj
Non‐canonical PKG1 regulation in cardiovascular health and disease
British Journal of Pharmacology, EarlyView.It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley +1 more source
MoleculesEmerging contaminants (ECs) represent a growing environmental problem due to their presence in various environmental matrices. In Mexico, research on ECs remains limited.
Sheila Genoveva Pérez Bravo +5 more
doaj +1 more source
British Journal of Pharmacology, EarlyView.Abstract Ensifentrine (formerly called RPL 554) is a novel, first in class, inhaled bifunctional dual PDE3/4 inhibitor for the treatment of chronic respiratory diseases. Ensifentrine exhibits both bronchodilation via PDE3 inhibition and anti‐inflammatory activity via PDE4 inhibition.
Clive Page
wiley +1 more source
Ocular Manifestations of Metabolic Syndrome: A Systemic Vascular Phenotype
Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Context Metabolic syndrome (MetS) is defined by central obesity, insulin resistance, hypertension and dyslipidemia. MetS affects over one‐third of US adults. Beyond its cardiovascular burden, MetS has clinically relevant associations with ocular health and may contribute to a systemic vascular and neuro‐metabolic phenotype involving the retina,
Ron T. Varghese, Ansu A. John
wiley +1 more source
The FEBS Journal, EarlyView.Human NAD(P)H:quinone oxidoreductase 1 is a homodimeric flavoenzyme crucial for redox metabolism and linked to significant health issues. Point mutations at Tyr126 and Tyr128 demonstrate their essential roles in optimizing substrate binding geometry for catalysis, as well as in half‐site reactivity and conformational dynamics during the enzyme's ...
Maribel Rivero +8 more
wiley +1 more source
Transgenic selection and underlying mechanisms in apicomplexan parasites
The FEBS Journal, EarlyView.Transgenic selection markers have driven genetic engineering in apicomplexans, enabling precise, iterative experiments. This review discusses mechanistic details of drug selection markers, strategies for marker recycling, and practical considerations for several clinically relevant parasites.
Swaroop Peddiraju +2 more
wiley +1 more source