Results 21 to 30 of about 5,171 (202)

Exploration of isoxanthohumol bioconversion from spent hops into 8-prenylnaringenin using resting cells of Eubacterium limosum [PDF]

, 2020
Hops is an almost unique source of the potent phytoestrogen 8-prenylnaringenin (8-PN). As hops contain only low levels of 8-PN, synthesis may be more attractive than extraction.
Bolca, Selin, Goeman, Jan, Moens, Esther, Possemiers, Sam, Van de Wiele, Tom, Van Landschoot, Anita, Verstraete, Willy   +6 more
core   +2 more sources

Protective effects of Xanthohumol against diabetic nephropathy in a mouse model

Kidney & Blood Pressure Research, 2023
Introduction: Diabetic nephropathy (DN) is a long-term loss of renal function occurring in the diabetic patients, leading to 5 million deaths in 2015, and this number is dramatically growing annually.
Fenglin Li, Jinling Zhang, Le Luo, Jing Hu   +3 more
doaj   +1 more source

Microbial transformation of xanthohumol

Phytochemistry, 2003
Microbial transformation of xanthohumol using the culture broth of Pichia membranifaciens afforded three metabolites, (E)-2"-(2"'-hydroxyisopropyl)-dihydrofurano[2",3":4',3']-2', 4-dihydroxy-6'-methoxychalcone, (2S)-2"-(2"'-hydroxyisopropyl)-dihydrofurano[2",3":7,8]-4'-hydroxy-5-methoxyflavanone and (E)-2"-(2"'-hydroxyisopropyl)-dihydrofurano[2",3":2 ...
Wimal H M W, Herath, Daneel, Ferreira, Ikhlas A, Khan   +2 more
  +8 more sources

Xanthohumol microbiome and signature in healthy adults (the XMaS trial): a phase I triple-masked, placebo-controlled clinical trial

Trials, 2020
Background Natural products may provide a source for the discovery and development of adjunctive pharmacological interventions to modulate the inflammatory pathways contributing to chronic disease.
Ryan Bradley, Blake O. Langley, Jennifer J. Ryan, John Phipps, Douglas A. Hanes, Emily Stack, Janet K. Jansson, Thomas O. Metz, Jan Frederik Stevens   +8 more
doaj   +1 more source

Synthesis of Human Phase I and Phase II Metabolites of Hop (Humulus lupulus) Prenylated Flavonoids

Metabolites, 2022
Hop prenylated flavonoids have been investigated for their in vivo activities due to their broad spectrum of positive health effects. Previous studies on the metabolism of xanthohumol using untargeted methods have found that it is first degraded into 8 ...
Lance Buckett, Sabrina Schönberger, Veronika Spindler, Nadine Sus, Christian Schoergenhofer, Jan Frank, Oliver Frank, Michael Rychlik   +7 more
doaj   +1 more source

Exploring the Neuroprotective Effects of Xanthohumol and Quercetin for the treatment of Alzheimer's Disease [PDF]

Alzheimers Dement
Abstract Background Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and impaired neurocognitive function. It is pathologically defined by neuronal degeneration, loss of neural tissue, and hallmark features such as neurofibrillary tangles (NFT) and amyloid‐beta (Aβ) plaques.
Bashir B, Singh S, Gulati M, Vishwas S, Khandale N, Pal B, Panda S.   +6 more
europepmc   +2 more sources

Activation of proestrogens from hops (Humulus lupulus L.) by intestinal microbiota; Conversion of isoxanthohumol into 8-prenylnaringenin [PDF]

, 2005
Hop, an essential ingredient in most beers, contains a number of prenylflavonoids, among which 8-prenylnaringenin (8-PN) would be the most potent phytoestrogen currently known. Although a number of health effects are attributed to these compounds, only a
De Keukeleire, Denis, Heyerick, Arne, Possemiers, Sam, Robbens, Veerle, Verstraete, Willy   +4 more
core   +2 more sources

The hop constituent xanthohumol exhibits hepatoprotective effects and inhibits the activation of hepatic stellate cells at different levels

Frontiers in Physiology, 2015
Xanthohumol is the principal prenylated flavonoid of the female inflorescences of the hop plant. In recent years, various beneficial xanthohumol effects including anti-inflammatory, antioxidant, hypoglycemic activities, and anticancer effects have been ...
Ralf eWeiskirchen, Abdo eMahli, Sabine eWeiskirchen, Claus eHellerbrand   +3 more
doaj   +1 more source

Xanthohumol, a Prenylated Chalcone from Hops, Inhibits the Viability and Stemness of Doxorubicin-Resistant MCF-7/ADR Cells

Molecules, 2016
Xanthohumol is a unique prenylated flavonoid in hops (Humulus lupulus L.) and beer. Xanthohumol has been shown to possess a variety of pharmacological activities.
Ming Liu, Hua Yin, Xiaokun Qian, Jianjun Dong, Zhonghua Qian, Jinlai Miao   +5 more
doaj   +1 more source

Attenuation of Pancreatic Cancer In Vitro and In Vivo via Modulation of Nrf2 and NF-κB Signaling Pathways by Natural Compounds

Cells, 2021
Pancreatic cancer is a disease in which deregulation of signaling pathways plays a key role, thus searching for their novel modulators is a promising therapeutic strategy.
Marta Cykowiak, Robert Kleszcz, Małgorzata Kucińska, Jarosław Paluszczak, Hanna Szaefer, Adam Plewiński, Hanna Piotrowska-Kempisty, Marek Murias, Violetta Krajka-Kuźniak   +8 more
doaj   +1 more source