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The Function of Xenobiotic Receptors in Metabolic Diseases
Drug Metabolism and Disposition, 2023Metabolic diseases are a series of metabolic disorders that include obesity, diabetes, insulin resistance, hypertension, and hyperlipidemia. The increased prevalence of metabolic diseases has resulted in higher mortality and mobility rates over the past decades, and this has led to extensive research focusing on the underlying mechanisms.
Jinhang, Zhang +3 more
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Animal Models of Xenobiotic Receptors
Current Drug Metabolism, 2005Retinoid X receptors (RXRs) form heterodimers with pregnane X receptor (PXR) and constitutive androstane receptor (CAR), two prototypical xenobiotic receptors, and mediate metabolism of xenobiotics (foreign compounds) and endobiotics (endogenous compounds).
Guoli, Dai, Yu-Jui Yvonne, Wan
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Xenobiotic receptor knockout mice
Toxicology Letters, 1995Administration of certain foreign chemicals to animals elicits responses that are due to receptor-mediated activation of gene expression. Among the most well studied receptors are the Ah receptor (AHR) that binds 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds and the peroxisome proliferator-activated receptors, PPARs, that mediate gene ...
F J, Gonzalez +4 more
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Regulation of Sulfotransferases by Xenobiotic Receptors
Current Drug Metabolism, 2005The transcription factor networks that regulate basal and xenobiotic-modulated expression of the hepatic sulfotransferases affect the dynamics of xenobiotic detoxication, carcinogen bioactivation and metabolic homeostasis. Emerging evidence suggests that liver-enriched transcription factors, the aryl hydrocarbon (Ah) receptor and members of the nuclear
M, Runge-Morris, T A, Kocarek
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Regulation of Hepatic Transporters by Xenobiotic Receptors
Current Drug Metabolism, 2005Chemicals that increase expression of phase-I and -II biotransformation enzymes in liver, as well as enhance hepatic uptake and biliary excretion are often referred to as microsomal enzyme inducers (MEIs). Early studies suggested that drug metabolism might be coordinately regulated along with drug efflux from hepatocytes as a means for the liver to rid
C D, Klaassen, A L, Slitt
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Xenobiotics and the Glucocorticoid Receptor
Toxicology and Applied Pharmacology, 2017Glucocorticoid Receptor (GR) is present in virtually every human cell type. Representing a nuclear receptor superfamily, GR has several different isoforms essentially acting as ligand-dependent transcription factors, regulating glucocorticoid-responsive gene expression in both a positive and a negative manner.
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Xenobiotic receptor humanized mice and their utility
Drug Metabolism Reviews, 2012The nuclear receptors pregnane X receptor, constitutive androstane receptor, and peroxisome proliferator-activated receptor alpha have important endogenous functions and are also involved in the induction of drug-metabolizing enzymes and transporters in response to exogenous xenobiotics. Though not belonging to the same protein family, the Per-Sim-ARNT
Scheer, Nico (Prof. Dr. rer. nat.) +1 more
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Transient Receptor Potential Vanilloid 1 and Xenobiotics
CNS & Neurological Disorders - Drug Targets, 2008Over the last couple of years, transient receptor potential vanilloid 1(TRPV1) channels have been a hot topic in ion channel research. Since this research field is still rather new, there is not much known about the working mechanism of TRPV1 and its ligands.
E, Cuypers +4 more
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Augmentation of estrogen receptor-mediated transcription by steroid and xenobiotic receptor
Endocrine, 2008The estrogen receptor (ER) is a key regulator of proliferation and differentiation in breast cancer cells. In the present study, the effect of steroid and xenobiotic receptor (SXR) on 17/beta-estradiol (E2)-induced transcription through ERalpha was studied.
Nana, Rokutanda +11 more
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Xenobiotic Receptors CAR and PXR
2010The absorption, distribution, metabolism, and excretion (ADME) of chemicals are coordinately fulfilled by drug transporters as well as phase-I and phase-II drug-metabolizing enzymes. The two so-called “xenobiotic receptors”, namely constitutive active/androstane receptor (CAR, NR1I3) and pregnane X receptor (PXR, NR1I2), are predominantly expressed in ...
Curtis Klaassen, Hong Lu
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