Results 121 to 130 of about 19,512 (146)

Multiple Enhancer Units Mediate Drug Induction of CYP2H1 by Xenobiotic-Sensing Orphan Nuclear Receptor Chicken Xenobiotic Receptor

Molecular Pharmacology, 2001
Binding of nuclear receptors to drug-responsive enhancer units mediates transcriptional activation of cytochromes P-450 (P-450) by drugs and xenobiotics. In previous studies, a 264-base-pair (bp) phenobarbital-responsive enhancer unit (PBRU) located at -1671 to -1408 upstream of the chicken CYP2H1 transcriptional start-site increased gene expression ...
Handschin, C., Podvinec, M., Looser, R., Amherd, R., Meyer, U. A.   +4 more
openaire   +2 more sources

Regulation of Xenobiotic Detoxification by Nuclear Receptors

Medicinal Chemistry Research, 2004
Cytochromes P450 (CYP) from families CYP1, CYP2 and CYP3 are involved in xenobiotic detoxication and are regulated by numerous agents including xenobiotics, bile salts and cytokines. Nuclear receptors PXR (Pregnane X Receptor, NR1I3) and CAR (Constitutive Androstane Receptor, NR1I2) control the expression of distinct but overlapping arrays of genes ...
JM Pascussi, S Gerbal-Chaloin, L Drocourt, L Pichard-Garcia, MJ Vilarem, P Maurel   +5 more
openaire   +1 more source

Vitamin E, nuclear receptors and xenobiotic metabolism

Archives of Biochemistry and Biophysics, 2004
Supplemental vitamin E (alpha-tocopherol) is taken daily by more than 35 million people in the US. Following absorption and liver uptake, the fate of vitamin E is largely unknown. Of potential importance are recent clinical studies that have reported adverse effects of vitamin E that may be directly related to its hepatic metabolism.
openaire   +2 more sources

Ah receptor: xenobiotic response meets inflammation

Blood, 2008
AhR mediates a broad range of biological responses to environmental chemicals, including suppression of immune functions. In this issue of Blood , Lawrence and colleagues demonstrate that AhR is responsible for the anti-inflammatory activity of new antiallergic drug candidates, likely by ...
openaire   +2 more sources

Special Section on Xenobiotic Receptors–Editorial

Drug Metabolism and Disposition, 2023
Xiao-Bo, Zhong, Yurong, Lai
openaire   +2 more sources

Atypical functions of xenobiotic receptors in lipid and glucose metabolism

Medical Review, 2023
Peipei Lu, Wen Xie
exaly  

Cadmium exposure induces mitochondrial pathway apoptosis in swine myocardium through xenobiotic receptors-mediated CYP450s activation

Journal of Inorganic Biochemistry, 2021
Xia Zhao, Xiaojing Li, Shengchen Wang
exaly  

The protection of selenium against cadmium-induced mitophagy via modulating nuclear xenobiotic receptors response and oxidative stress in the liver of rabbits

Environmental Pollution, 2021
Huabin Cao, Caiying Zhang, Junrong Luo   +2 more
exaly  

Xenobiotic Receptor

2011
openaire   +1 more source

Xenobiotic Receptor

2017
openaire   +1 more source