Results 11 to 20 of about 149,321 (334)

Revisited: Therapeutic and toxic blood concentrations of more than 1100 drugs and other xenobiotics

Critical Care, 2020
In order to assess the significance of drug/substance levels measured in intensive care medicine and clinical and forensic toxicology as well as for therapeutic drug monitoring, it is essential that a comprehensive collection of data is readily available.
M. Schulz, A. Schmoldt, H. Andresen‑Streichert, S. Iwersen-Bergmann   +3 more
semanticscholar   +1 more source

Microcystins: Potent xenobiotics [PDF]

Archive of Oncology, 2011
Having in mind that exposure to low levels of microcystin in drinking water represents the health risk for people, microcystins can be observed as potent xenobiotics.
Ilić Maja, Svirčev Zorica, Baltić Vladimir   +2 more
doaj   +1 more source

Toxicomicrobiomics: The Human Microbiome vs. Pharmaceutical, Dietary, and Environmental Xenobiotics

Frontiers in Pharmacology, 2020
The harmful impact of xenobiotics on the environment and human health is being more widely recognized; yet, inter- and intraindividual genetic variations among humans modulate the extent of harm, mostly through modulating the outcome of xenobiotic ...
N. Abdelsalam, A. Ramadan, M. ElRakaiby, R. Aziz   +3 more
semanticscholar   +1 more source

“Commandeuring” Xenobiotic Metabolism: Advances in Understanding Xenobiotic Metabolism

Chemical Research in Toxicology, 2022
The understanding of how exogenous chemicals (xenobiotics) are metabolized, distributed, and eliminated is critical to determine the impact of the chemical and its metabolites to the (human) organism. This is part of the research and educational discipline ADMET (absorption, distribution, metabolism, elimination, and toxicity). Here, we review the work
Barbara M. A. van Vugt-Lussenburg, Liliana Capinha, Jelle Reinen, Martijn Rooseboom, Michel Kranendonk, Rob C. A. Onderwater, Paul Jennings   +6 more
openaire   +3 more sources

Mechanism of Two-/Four-Electron Reduction of Nitroaromatics by Oxygen-Insensitive Nitroreductases: The Role of a Non-Enzymatic Reduction Step

Molecules, 2018
Oxygen-insensitive NAD(P)H:nitroreductases (NR) reduce nitroaromatics (Ar-NO2) into hydroxylamines (Ar-NHOH) through nitroso (Ar-NO) intermediates. Ar-NO may be reduced both enzymatically and directly by reduced nicotinamide adenine dinucleotide or its ...
Benjaminas Valiauga, Lina Misevičienė, Michelle H. Rich, David F. Ackerley, Jonas Šarlauskas, Narimantas Čėnas   +5 more
doaj   +1 more source

Time and dose-dependent effects of phenobarbital on the rat liver miRNAome. [PDF]

, 2013
In a previous study we had shown that treatment of male Fischer rats with exogenous chemicals for three months resulted in prominent, mode-of-action dependent effects on liver microRNA (miRNA) (Koufaris et al., 2012). Here we investigated how the effects
Currie, RA, Gooderham, NJ, Koufaris, C, Osborne, M, Wright, J   +4 more
core   +1 more source

Incorporating the Gut Microbiome in the Risk Assessment of Xenobiotics and Identifying Beneficial Components for One Health

Frontiers in Microbiology, 2022
Three areas of relevance to the gut microbiome in the context of One Health were explored; the incorporation of the microbiome in food safety risk assessment of xenobiotics; the identification and application of beneficial microbial components to various
Antonis Ampatzoglou, Antonis Ampatzoglou, Agnieszka Gruszecka-Kosowska, Agnieszka Gruszecka-Kosowska, Agnieszka Gruszecka-Kosowska, Alfonso Torres-Sánchez, Alfonso Torres-Sánchez, Ana López-Moreno, Ana López-Moreno, Ana López-Moreno, Klara Cerk, Klara Cerk, Pilar Ortiz, Pilar Ortiz, Mercedes Monteoliva-Sánchez, Mercedes Monteoliva-Sánchez, Margarita Aguilera, Margarita Aguilera, Margarita Aguilera   +18 more
doaj   +1 more source

Aspects of xenobiotics and their receptors in stroke

Neuroprotection, 2023
Stroke is devastating and the second leading cause of disability and death worldwide. The pathophysiology of stroke is intricate involving oxidative stress, ionic imbalance, and excitotoxicity leading to cell death. The current therapeutic strategies for
Aishika Datta, Bijoyani Ghosh, Deepaneeta Sarmah, Antra Chaudhary, Anupom Borah, Pallab Bhattacharya   +5 more
doaj   +1 more source

Chemical transformation of xenobiotics by the human gut microbiota

Science, 2017
One person's meat is another's poison The human gut is packed with actively metabolizing microorganisms. These have a transformative effect on what we ingest—whether food, drugs, or pollutants. Koppel et al.
N. Koppel, Vayu Maini Rekdal, E. Balskus
semanticscholar   +1 more source

Advantages of using biofilms to obtain high-value molecules by microbial biotransformations [PDF]

Exploration of Drug Science
Microbial biotransformations are valuable tools from “green chemistry” and involve converting parental molecules into new daughter ones with unique physical, chemical, or pharmacological properties.
Nicoly Subtil de Oliveira, Romeu Cassiano Pucci da Silva Ramos, Rafaela Caldas de Paula, Matheus Gonçalves da Costa Pereira, Rosimeire Takaki Rosa, Luiz Fernando Bianchini, Edvaldo Antonio Ribeiro Rosa   +6 more
doaj   +1 more source