Results 91 to 100 of about 22,610 (295)

GPC1 specific CAR-T cells eradicate established solid tumor without adverse effects and synergize with anti-PD-1 Ab

eLife, 2020
Current xenogeneic mouse models cannot evaluate on-target off-tumor adverse effect, hindering the development of chimeric antigen receptor (CAR) T cell therapies for solid tumors, due to limited human/mouse cross-reactivity of antibodies used in CAR and ...
Daiki Kato, Tomonori Yaguchi, Takashi Iwata, Yuki Katoh, Kenji Morii, Kinya Tsubota, Yoshiaki Takise, Masaki Tamiya, Haruhiko Kamada, Hiroki Akiba, Kouhei Tsumoto, Satoshi Serada, Tetsuji Naka, Ryohei Nishimura, Takayuki Nakagawa, Yutaka Kawakami   +15 more
doaj   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

Impact of bone marrow-derived mesenchymal stromal cells on experimental xenogeneic graft-versus-host disease [PDF]

, 2013
peer reviewedBackground aims. Graft-versus-host disease (GVHD) is a life-threatening complication of allogeneic hematopoietic cell transplantation caused by donor T cells reacting against host tissues.
Bruck, France, Beguin, Yves, BRIQUET, Alexandra, Belle, Ludovic, Hannon, Muriel, CASTERMANS, Emilie, DUBOIS, Sophie, de Leval, Laurence, Humblet-Baron, Stéphanie, Baron, Frédéric, Rahmouni, Souad, LECHANTEUR, Chantal   +11 more
core   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

MOESM1 of The assessment of xenogeneic bone immunotoxicity and risk management study

, 2019
Additional file 1: Figure S1. Xenogeneic bones have no effect on the weights of xenograft mice. Animals were weighed on the day prior to treatment, on alternate weeks until day of sacrifice, and on day of ...
Likui Sun (7868357), Chenghu Liu (7868351), Xiaoxia Sun (684999), Yanping Shi (7868354), Chunling Li (234046), Xin Wang (91924), Li Hou (460220)   +6 more
core   +1 more source

Cell-Based Assays for Modeling Xenogeneic Immune Responses

, 2020
Research in xenotransplantation implies a high experimental complexity comprising molecular, cellular, and in vivo studies to investigate the mechanisms of xenograft immune rejection and functional failure, as well as the strategies to counteract them ...
Sommaggio, Roberta, Magdiel Pérez-Cruz, Pérez-Cruz, Magdiel, Kelly Casós, Cristina Costa, Casós, Kelly, Costa, Cristina, Roberta Sommaggio   +7 more
core   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Allogeneic and xenogeneic cytotoxic antibodies in man.

, 1969
Studies were made of in vitro cytotoxicity of human serum on rat bone marrow and spleen cells (xenogeneic system) as well as human lymphocytes (allogeneic system). Cytotoxicity was measured by trypan blue staining and C14-uridine incorporation.
Oh, Jung H.
core  

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Comparative efficacies of long-term serial transplantation of syngeneic, allogeneic, xenogeneic, or CTLA4Ig-overproducing xenogeneic adipose tissue-derived mesenchymal stem cells on murine systemic lupus erythematosus

, 2016
Allogeneic and xenogeneic transplantation are suitable alternatives for treating patients with stem cell defects and autoimmune diseases. The purpose of this study was to compare the effects of long-term serial transplantation of adipose tissue-derived ...
Choi, Eun Wha, Shin, Il Seob, Youn, Hwa Young, Kim, Sung-Joo, Yun, Tae Won, Lee, Hee Woo, Park, Ji Hyun   +6 more
core   +1 more source