Results 71 to 80 of about 22,610 (295)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Contamination in Bone Substitute Materials: A Systematic Review

Applied Sciences
Objective: Bone augmentation has become a significant practice in various areas of bone regeneration dentistry. This systematic review analyzes the research focused on evaluating bone substitute materials for the presence of contaminants.
Natalia Struzik, Julia Kensy, Paweł J. Piszko, Jan Kiryk, Kamila Wiśniewska, Sylwia Kiryk, Łuksza Korjat, Tomasz Horodniczy, Paulina Sobierajska, Jacek Matys, Rafal J. Wiglusz, Maciej Dobrzyński   +11 more
doaj   +1 more source

Rejection monitoring in xenogeneic auxiliary liver recipients.

, 2018
(A) Histological appearance of xenogeneic auxiliary liver from animals undergoing 90%Hx+ XHALT at the time of exploratory laparotomy and at graftectomy indicating absence of rejection signs.
Nalu Navarro-Alvarez (3044484), Nahel Elias (3153927), David H. Sachs (6000449), Alexander Zhu (6000443), Leo Buhler (301212), James F. Markmann (495075), Heidi Yeh (301202), Zurab Machaidze (301205), Christian Schuetz (301207), Jigesh A. Shah (6000446), Parsia A. Vagefi (831964), Wei-hui Liu (211269)   +11 more
core   +1 more source

CSBD Healing in Rats after Application of Bovine Xenogeneic Biomaterial Enriched with Magnesium Alloy

, 2021
Xenogeneic biomaterials Cerbone® and OsteoBiol® are widely used in oral implantology. In dental practice, xenogeneic biomaterial is usually combined with autologous bone to provide bone volume stability needed for long-term dental implants.
Matko Oguić, Tomas, Matej, Igor Erjavec, Cvijanović Peloza, Olga, Oguić, Matko, Ana Terezija Jerbić Radetić, Perić Kačarević, Željka, Erjavec, Igor, Matej Tomas, Sanja Zoričić Cvek, Željka Perić Kačarević, Jerbić Radetić, Ana Terezija, Olga Cvijanović Peloza, Zoričić Cvek, Sanja   +13 more
core   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Evaluating the safety and efficacy of equine peripheral blood-derived mesenchymal stem cells in feline chronic gingivostomatitis

Frontiers in Veterinary Science
IntroductionFeline chronic gingivostomatitis (FCGS) is a painful chronic disease with limited treatment options, especially in severe cases. For this reason, regenerative therapies are being explored as a potential solution.MethodsThe current study ...
Nathalie de Bouvre, Charlotte Beerts, Sarah Y. Broeckx, Eva Depuydt, Liesa Tack, Glenn Pauwelyn, Luc Duchateau, Jimmy Saunders, Jan H. Spaas, Jan H. Spaas   +9 more
doaj   +1 more source

Clinical observation on healing of tarsal plate defect after reconstruction with xenogeneic acellular dermal matrix

BMC Ophthalmology, 2022
Objective To evaluate the safety, function, and cosmetic outcome of eyelid reconstruction using a xenogeneic acellular dermal matrix as a tarsal plate replacement in the repair of 50 to 100% eyelid defects following excision of large malignant tumours ...
Qin Huang, Yangbin Fang, Yaohua Wang, Hongfei Liao   +3 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source