Results 61 to 70 of about 22,610 (295)

Classical Complement Pathway Inhibition in a Pediatric Patient With Refractory Immune Thrombocytopenia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric refractory immune thrombocytopenia (rITP) is generally characterized by persistent thrombocytopenia and failure to achieve a sustained response to multiple standard therapies. We report a 4‐year‐old female with congenital tufting enteropathy, post‐intestinal transplant patient on immunosuppressants, who developed severe rITP ...
Sarah Hsieh, Susmita Sarangi, Caileigh Pudela, Catherine M. Broome, Tara K. Suntum   +4 more
wiley   +1 more source

Abatacept for Prophylaxis of Acute and Chronic Graft‐Versus‐Host‐Disease in Children Undergoing Allogeneic Hematopoietic Stem Cell Transplantation—A Systematic Review and Meta‐Analysis of Cohort Studies

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Graft‐versus‐host disease (GvHD) remains one of the most significant complications of hematopoietic stem cell transplantation (HSCT). Abatacept, a selective T‐cell costimulation modulator, is a relatively novel prophylactic agent, though pediatric data remain limited.
Matthijs D. Kruizinga, Anne B. Verbeek, Caroline A. Lindemans, Emilie P. Buddingh   +3 more
wiley   +1 more source

A randomized, prospective, placebo-controlled feasibility study of systemic administration of equine peripheral blood-derived mesenchymal stem cells in feline chronic kidney disease

Frontiers in Veterinary Science
Feline chronic kidney disease (CKD) is one of the most frequently diagnosed diseases in cats and affects particular older cats. Regenerative therapies are being explored as a potential solution since current treatments largely address symptoms and ...
Nathalie de Bouvre, Charlotte Beerts, Sarah Y. Broeckx, Eva Depuydt, Liesa Tack, Glenn Pauwelyn, Laurens Van Mulders, Ellen Vanden Broecke, Luc Duchateau, Jimmy Saunders, Sophie Vandenabeele, Sylvie Daminet, Jan H. Spaas, Jan H. Spaas   +13 more
doaj   +1 more source

Xenogeneic cell therapy provides a novel potential therapeutic option for cancers by restoring tissue function, repairing cancer wound and reviving anti-tumor immune responses

Cancer Cell International, 2018
Conventional cancer treatments such as surgery, radiotherapy, chemotherapy and targeted therapy, not only destruct tumors, but also injure the normal tissues, resulting in limited efficacy.
Chi-Ping Huang, Chi-Cheng Chen, Chih-Rong Shyr   +2 more
doaj   +1 more source

Clinical and laboratorial outcomes of xenogeneic biomaterials: literature review

, 2023
Background and Objective: Bone regeneration procedures are an important part of oral and maxillofacial surgery development, With the rising of dental implants research and techniques, bone augmentation became an essential also for oral implantology.
Pereira-Filho, Valfrido Antonio [UNESP], de Oliveira Ciaramicolo, Nathaly, de Azambuja Carvalho, Pedro Henrique [UNESP], Ferreira Júnior, Osny, Pereira-Filho, Valfrido Antonio, Valfrido Antonio Pereira-Filho, Osny Ferreira Júnior, Pedro Henrique de Azambuja Carvalho, Nathaly de Oliveira Ciaramicolo   +8 more
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Interspecific germline transmission of cultured primordial germ cells. [PDF]

PLoS ONE, 2012
In birds, the primordial germ cell (PGC) lineage separates from the soma within 24 h following fertilization. Here we show that the endogenous population of about 200 PGCs from a single chicken embryo can be expanded one million fold in culture.
Marie-Cecile van de Lavoir, Ellen J Collarini, Philip A Leighton, Jeffrey Fesler, Daniel R Lu, William D Harriman, T S Thiyagasundaram, Robert J Etches   +7 more
doaj   +1 more source

Xenogeneic islet transplantation

Xenotransplantation, 1999
Simeonivic C J. Xenogeneic islet transplantation. Xenotransplantation 1999; 6: 00‐00. ©Munksgaard, Copenhagen.
openaire   +3 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source