Results 21 to 30 of about 22,610 (295)

A Biohybrid Material With Extracellular Matrix Core and Polymeric Coating as a Cell Honing Cardiovascular Tissue Substitute

Frontiers in Cardiovascular Medicine, 2022
ObjectiveTo investigate the feasibility of a hybrid material in which decellularized pericardial extracellular matrix is functionalized with polymeric nanofibers, for use as a cardiovascular tissue substitute.BackgroundA cardiovascular tissue substitute,
Jahnavi Mudigonda, Jahnavi Mudigonda, Dongyang Xu, Dongyang Xu, Alan Amedi, Alan Amedi, Brooks A. Lane, Brooks A. Lane, Daniella Corporan, Daniella Corporan, Vivian Wang, Muralidhar Padala, Muralidhar Padala   +12 more
doaj   +1 more source

Chondrogenically Primed Human Mesenchymal Stem Cells Persist and Undergo Early Stages of Endochondral Ossification in an Immunocompetent Xenogeneic Model

Frontiers in Immunology, 2021
Tissue engineering approaches using progenitor cells such as mesenchymal stromal cells (MSCs) represent a promising strategy to regenerate bone. Previous work has demonstrated the potential of chondrogenically primed human MSCs to recapitulate the ...
Niamh Fahy, Niamh Fahy, Virginia Palomares Cabeza, Virginia Palomares Cabeza, Virginia Palomares Cabeza, Andrea Lolli, Janneke Witte-Bouma, Ana Merino, Yanto Ridwan, Yanto Ridwan, Eppo B. Wolvius, Martin J. Hoogduijn, Eric Farrell, Pieter A. J. Brama   +13 more
doaj   +1 more source

Xenogeneic equine stem cells activate anti-tumor adaptive immunity in a 4T1-based intraductal mouse model for triple-negative breast cancer: proof-of-principle

Frontiers in Immunology, 2023
Triple-negative breast cancer (TNBC) remains difficult to treat, especially due to ineffective immune responses. Current treatments mainly aim at a cytotoxic effect, whereas (stem) cell therapies are being investigated for their immune stimulatory ...
Jonas Steenbrugge, Jonas Steenbrugge, Glenn Pauwelyn, Kristel Demeyere, Nausikaa Devriendt, Hilde de Rooster, Hilde de Rooster, Niek N. Sanders, Niek N. Sanders, Jan H. Spaas, Jan H. Spaas, Evelyne Meyer, Evelyne Meyer   +12 more
doaj   +1 more source

Xenogeneic transplantation [PDF]

British Medical Bulletin, 1997
Hyperacute rejection, the previously insurmountable obstacle to pig-to-human xenografts, has been overcome. There is reason to hope that concerted research will overcome the remaining obstacles. Pigs will be produced expressing other regulators of complement activation molecules in addition to decay accelerating factor.
J, van den Bogaerde, D J, White
openaire   +2 more sources

Review: Mesenchymal Stem Cell Therapy in Canine Osteoarthritis Research: “Experientia Docet” (Experience Will Teach Us)

Frontiers in Veterinary Science, 2021
Osteoarthritis (OA) is currently an incurable and progressive condition in dogs causing chronic joint pain and possibly increasing disability. Due to the poor healing capacity of cartilage lesions that occur with OA, development of effective therapeutics
Carlien Brondeel, Glenn Pauwelyn, Evelien de Bakker, Jimmy Saunders, Yves Samoy, Jan H. Spaas, Jan H. Spaas   +6 more
doaj   +1 more source

Local, systemic and immunologic safety comparison between xenogeneic equine umbilical cord mesenchymal stem cells, allogeneic canine adipose mesenchymal stem cells and placebo: a randomized controlled trial

Frontiers in Veterinary Science, 2023
Mesenchymal stem cells are multipotent cells with a wide range of therapeutic applications, including, among others, tissue regeneration. This work aims to test the safety (EUC-MSC) of intra-articular administration of equine umbilical cord mesenchymal ...
Eva Punzón, María García-Castillo, Miguel A. Rico, Laura Padilla, Almudena Pradera   +4 more
doaj   +1 more source

Xenogeneic silencing strategies in bacteria are dictated by RNA polymerase promiscuity [PDF]

, 2022
Horizontal gene transfer facilitates dissemination of favourable traits among bacteria. However, foreign DNA can also reduce host fitness: incoming sequences with a higher AT content than the host genome can misdirect transcription.
Forrest, David, Warman, Emily A; id_orcid, Grainger, David C, Erkelens, Amanda M, Dame, Remus T   +4 more
core   +3 more sources

Impact of Ig-Therasorb (R) immunoapheresis on stability of xenogeneic ex vivo porcine liver perfusion - Value of aminotransferases and flow rates for the assessment of metabolic graft viability [PDF]

, 2000
Due to growing shortage of donor organs, the concept of extracorporeal pig liver perfusion in the treatment of acute liver failure has been rediscovered.
Scheele, Johannes, Dietz, Oliver, Kornberg, Arno, Hammer, Claus, Mau, Henning   +4 more
core   +1 more source

Immunological and functional features of decellularized xenogeneic heart valves after transplantation into GGTA1-KO pigs [PDF]

, 2021
Decellularization of xenogeneic heart valves might lead to excellent regenerative implants, from which many patients could benefit. However, this material carries various xenogeneic epitopes and thus bears a considerable inherent immunological risk. Here,
Goecke, Tobias, Tudorache, Igor, Sarikouch, Samir, Petersen, Björn, Haverich, Axel, Ramm, Robert, Höffler, Klaus, Cebotari, Serghei, Hilfiker, Andres, Ciubotaru, Anatol, Köhler, Peter, Bothe, Friederike, Niemann, Heiner, Björn Petersen, Igor Tudorache, Tobias Goecke, Andres Hilfiker, Friederike Bothe, Serghei Cebotari, Anatol Ciubotaru, Samir Sarikouch, Robert Ramm, Heiner Niemann, Klaus Höffler, Peter Köhler, Axel Haverich   +25 more
core   +1 more source

Organs from animals for man [PDF]

, 1998
In the following review some of the problems of xenotransplantation shall be discussed, based on the few experimental data available so far and on reports in the literature describing investigations which may be of importance for xenotransplantation. The
Diefenbeck, M., Hammer, C., Wagner, F., Linke, R.   +3 more
core   +1 more source