Results 91 to 100 of about 137,536 (254)

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

Xenopus Models of Cancer: Expanding the Oncologist’s Toolbox

Frontiers in Physiology, 2018
The use of the Xenopus model system has provided diverse contributions to cancer research, not least because of the striking parallels between tumour pathogenesis and early embryo development.
Laura J. A. Hardwick, Laura J. A. Hardwick, Laura J. A. Hardwick, Anna Philpott, Anna Philpott   +4 more
doaj   +1 more source

Cross‐Linking Mass Spectrometry of the Antimicrobial Peptides Magainin 2 and PGLa Reveals Heterodimerization in Micellar Medium

Rapid Communications in Mass Spectrometry, EarlyView.
ABSTRACT Rationale In this study, we applied cross‐linking mass spectrometry (XL‐MS) to characterize the oligomeric states of a PGLa/magainin 2 mixture and gain insight into the heterodimerization previously suggested in the literature. Both peptides have shown a synergistic enhancement of activity when tested in antimicrobial assays; however, the ...
Emilie Hirschler, Elise Glattard, Nicolas Arnaud, Johana Chicher, Philippe Hammann, Emmanuelle Leize‐Wagner, Burkhard Bechinger, Noelle Potier   +7 more
wiley   +1 more source

A Matter of the Heart: The African Clawed Frog Xenopus as a Model for Studying Vertebrate Cardiogenesis and Congenital Heart Defects

Journal of Cardiovascular Development and Disease, 2016
The African clawed frog, Xenopus, is a valuable non-mammalian model organism to investigate vertebrate heart development and to explore the underlying molecular mechanisms of human congenital heart defects (CHDs).
Annemarie Hempel, Michael Kühl
doaj   +1 more source

A Cytoplasmic pH Sensor Redefines Gating in Bacterial Urea Channels and Acid Resistance

Small, EarlyView.
Bacterial survival in acidic environments requires pH‐gated urea channels. Utilizing complementary approaches, we identify a conserved cytoplasmic glutamic acid residue as a pH sensor in UreI channels. Whereas Gram‐positive bacteria rely solely on this sensor, Gram‐negative bacteria employ a dual‐sensor mechanism with periplasmic residues, revealing a ...
Anna Stoib, Sahar Shojaei, Xenia Fischer, Sandra Posch, Gianluca Parisse, Mario Frezzini, Tobias Putz, Christine Siligan, Nikolaus Goessweiner‐Mohr, Daniele Narzi, Andreas Horner   +10 more
wiley   +1 more source

Xenbase: Facilitating the Use of Xenopus to Model Human Disease

Frontiers in Physiology, 2019
At a fundamental level most genes, signaling pathways, biological functions and organ systems are highly conserved between man and all vertebrate species. Leveraging this conservation, researchers are increasingly using the experimental advantages of the
Mardi J. Nenni, Malcolm E. Fisher, Christina James-Zorn, Troy J. Pells, Virgilio Ponferrada, Stanley Chu, Joshua D. Fortriede, Kevin A. Burns, Ying Wang, Vaneet S. Lotay, Dong Zhou Wang, Erik Segerdell, Praneet Chaturvedi, Kamran Karimi, Peter D. Vize, Aaron M. Zorn   +15 more
doaj   +1 more source

Geographical Variation in Thermal Adaptation of the Asiatic Toad (Bufo gargarizans)

Integrative Zoology, EarlyView.
Northern and southern populations of Bufo gargarizans exhibit coordinated divergence in thermal preference, resting metabolic rate, and TRPM4 temperature sensitivity along a climatic gradient. ABSTRACT Thermal adaptation in animals can manifest in multiple dimensions, yet few studies have integrated behavioral, physiological, and molecular perspectives
Longcheng Fan, Yonghua Wu
wiley   +1 more source

5-HT2B-mediated serotonin signalling participates in retinal and craniofacial morphogenesis during Xenopus laevis development

, 2007
Serotonin (5HT) is a neurotransmitter that mediates a wide variety of effects in the central and peripheral adult nervous system. Experimental evidences demonstrated that serotonin even has an important role as growth and differentiating factor for ...
I. NARDI, IRMA NARDI, MICHELA ORI, M. ORI, ELISA REISOLI, DE LUCCHINI, STEFANIA, E. REISOLI   +6 more
core  

Fertilization in the African clawed frog, Xenopus laevis, requires an egg-derived PLC to signal the fast block to polyspermy

microPublication Biology
Fertilization in Xenopus laevis triggers calcium release and membrane depolarization to activate the fast block to polyspermy. This depolarization requires phospholipase C (PLC) activity, but the identity and origin of the PLC remained unclear.
Kayla M. Komondor, Katherine G. Sharp, Anne E. Carlson   +2 more
doaj   +1 more source

Chromosome‐Level Genome Assembly of Strauchbufo raddei and Multi‐Omic Insights Into Drought Adaptation

Integrative Zoology, EarlyView.
ABSTRACT Understanding how amphibians adapt to terrestrial and arid environments is important for elucidating vertebrate terrestrialization. In this study, we present the first chromosome‐level, high‐quality genome assembly of Strauchbufo raddei, constructed using PacBio HiFi long‐read sequencing and Hi‐C scaffolding. The assembled genome is 4.47 Gb in
Fanrui Chen, Rui Su, Chengqi Wang, Shengnan Wang, Jinjing Wang, Yuquan Miao, Wenya Zhang, Wei Zhao   +7 more
wiley   +1 more source