Results 111 to 120 of about 137,536 (254)

Adam13 interacts with large protein complexes to regulate histone modification and gene expression

Frontiers in Cell and Developmental Biology
Cranial neural crest (CNC) cells are a key stem cell like tissue that contribute to most of the facial structures in vertebrates. A disintegrin and metalloproteinase (ADAM) family of proteins is essential for the induction and migration of the CNC.
Ankit Pandey, Helene Cousin, Shiv Kumar, Shiv Kumar, Shiv Kumar, Louis Taylor, Ashmita Chander, Kelsey Coppenrath, Nikko-Ideen Shaidani, Marko Horb, Dominique Alfandari   +10 more
doaj   +1 more source

Ploidy‐dependent modulation of DNA replication kinetics in Xenopus

The FEBS Journal, EarlyView.
Using an interspecies replication system with Xenopus frog species of different ploidy levels, we investigated how DNA replication adapts to polyploidization. While replication was slower in tetraploid than in diploid nuclei, dodecaploid nuclei unexpectedly replicated faster than tetraploid nuclei. Our findings show that increasing genome size does not
Hemalatha Narassimprakash, Olivier Haccard, Zhen Li, Nicolas Pollet, Kathrin Marheineke   +4 more
wiley   +1 more source

DNA replication is required for the checkpoint response to damaged DNA in Xenopus egg extracts. [PDF]

, 2002
Alkylating agents, such as methyl methanesulfonate (MMS), damage DNA and activate the DNA damage checkpoint. Although many of the checkpoint proteins that transduce damage signals have been identified and characterized, the mechanism that senses the ...
Lindsay, Howard D., Stokes, Matthew P., Van Hatten, Ruth, Michael, W. Matthew   +3 more
core   +2 more sources

Phosphorylation of BigH1 regulates its expression pattern and promotes embryonic development

The FEBS Journal, EarlyView.
Phosphorylation is a key regulator of the linker histone variant BigH1 during Drosophila embryogenesis. We reveal that N‐terminal phosphorylation promotes the timely removal of BigH1 from chromatin. In contrast, C‐terminal phosphorylation supports early nuclear divisions and embryonic viability.
Ramóna Pék, Aladár Pettkó‐Szandtner, Anikó Szabó, Balázs Vedelek, Bence György Gombás, Zoltán Villányi, Péter Vilmos, Imre Miklós Boros, László Henn, Gyula Timinszky   +9 more
wiley   +1 more source

Germ‐Cell Specification in Xenopus

, 2014
Primordial germ cells (PGCs) represent the only precursor stem cell population that normally gives rise to the gametes. For this reason, PGCs have been called the “stem cells of the species” and are prime examples of a normal totipotent state (Wylie ...
Mary Lou King, King, Mary Lou
core   +1 more source

RLIM‐associated neurodevelopmental disorders: From clinical spectrum to molecular mechanisms

The FEBS Journal, EarlyView.
RLIM (RNF12) is an E3 ubiquitin ligase essential for mammalian development. Loss‐of‐function variants cause Tønne–Kalscheuer syndrome, while duplications cause Xq13 duplication syndrome, highlighting RLIM dosage sensitivity. This review summarizes the genetics, clinical features, and molecular mechanisms of RLIM‐associated disorders, integrating ...
Madison Landon, Kyra Swildens, Vera M. Kalscheuer, Cristina Gontan, Francisco Bustos   +4 more
wiley   +1 more source

Injury-induced cooperation of InhibinβA and JunB is essential for cell proliferation in Xenopus tadpole tail regeneration

Scientific Reports
In animal species that have the capability of regenerating tissues and limbs, cell proliferation is enhanced after wound healing and is essential for the reconstruction of injured tissue.
Makoto Nakamura, Tatsuya Kyoda, Hitoshi Yoshida, Kimiko Takebayashi-Suzuki, Ryota Koike, Eri Takahashi, Yuka Moriyama, Marcin Wlizla, Marko E. Horb, Atsushi Suzuki   +9 more
doaj   +1 more source

Xenopus laevis Oocytes

, 2003
Xenopus oocytes are a versatile expression system particularly suited for membrane transporters and channels. Oocytes have little background activity and therefore offer a very high signal-to-noise ratio for transporter and channel characterization. This chapter provides an overview of the basic methods used for the analysis of membrane transporters in
openaire   +4 more sources

On the function of Xenopus Oct4 protein homologs: Molecular construction of dominant interference variants and functional analysis in early frog development [PDF]

, 2011
Embryonic development represents a sophisticated multistep process. Hereby, specification, patterning and differentiation of cells and tissue need to be extremely well regulated in a temporo-spatial manner. This is based on repression and activation of a
Michel, Laura
core   +1 more source

Photochemistry of CryB from Rhodobacter sphaeroides

Photochemistry and Photobiology, EarlyView.
Elucidation of the photochemistry of CryB from Rhodobacter sphaeroides was achieved from the nanosecond to second timescale. A fast (<5 ns) deprotonation of the terminal electron donor Trp338 and the involvement of Tyr337 in photoreduction have been revealed.
Christopher Einholz, Johannes Ruhnke, Jonas Diez, Andreas Günter, Johannes Berger, Stefan Weber, Erik Schleicher   +6 more
wiley   +1 more source