Results 131 to 140 of about 137,536 (254)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, Volume 20, Issue 11, Page 2918-2935, November 2026.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

HMGA2 and HMGAx proteins in Xenopus laevis

, 2010
HMGA proteins are chromatin “architectural modifiers”, bearing conserved “AT-hook” motifs with which they bind to DNA AT-rich regions to assist in gene transcription.
MILANI O, VIGNALI, ROBERT, ROS G, SGARRA R, MACRÌ S, MANFIOLETTI G., MAURIZIO E, ZAMMITTI S   +7 more
core  

Anatomical Network Analyses of Pre‐ and Post‐Metamorphic Cranial Systems Support the Adaptive Decoupling Hypothesis in Anura

Journal of Morphology, Volume 287, Issue 11, November 2026.
Cranial musculoskeletal descriptions of anurans can be used to describe the topology (organizational structure). The topology of pre‐metamorphic anurans is more integrated and less modular than that of post‐metamorphics. Topologies cluster consistently with similar life phases, despite different feeding or reproductive modes and thereby support the ...
Lorenz Guschker, Maximilian A. Stüwe, Hendrik Müller, Benjamin Naumann   +3 more
wiley   +1 more source

Co-ordinating retinal histogenesis: early cell cycle exit enhances early cell fate determination in the Xenopus retina [PDF]

, 2002
The laminar arrays of distinct cell types in the vertebrate retina are built by a histogenic process in which cell fate is correlated with birth order.
Philpott, A., Wang, K.C., Ohnuma, S.-I., Hopper, S., Harris, W.A.   +4 more
core  

Late INa as a Therapeutic Target: New Strategies, Computational Modelling, Drug Development, and Clinical Translation

Medicinal Research Reviews, Volume 46, Issue 6, Page 1939-1957, November 2026.
ABSTRACT The Nav1.5 channel, a major isoform of voltage‐gated sodium ion channel, is mainly found in ventricular cardiomyocytes, playing a key role in generating essential cardiac action potentials for normal heart rhythms. Mutations in Nav1.5 have been associated with severe heart conditions such as long QT syndrome, Brugada syndrome, cardiac ...
Arkapravo Chattopadhyay, Lynn C. Lunsonga, Peter E. Light, Khaled Barakat   +3 more
wiley   +1 more source

A Case of Distal Hereditary Motor Neuronopathy‐7 With Two Novel VWA1 Variants in Compound Heterozygosity

Neurology and Clinical Neuroscience, Volume 14, Issue 6, Page 493-496, November 2026.
ABSTRACT Distal hereditary motor neuronopathy‐7 (HMNR7) is an autosomal recessive VWA1‐related disorder characterized predominantly by distal motor involvement. A 41‐year‐old man with a history of childhood orthopedic surgery for foot deformities exhibited progressive distal weakness and muscle atrophy with lower limb predominance. Electrophysiological
Toshiyuki Kakumoto, Kenta Orimo, Takashi Matsukawa, Jun Mitsui, Shoji Tsuji   +4 more
wiley   +1 more source

CRISPR/Cas-mediated mRNA knockdown in the embryos of Xenopus tropicalis

Cell & Bioscience
The Xenopus tropicalis (Western clawed frog) is an important amphibian model for genetics, developmental and regenerative biology, due to its diploid genetic background and short generation time.
Xiao-Lin Lin, Yi-Min Zhou, Ke Meng, Jia-Yi Yang, Han Zhang, Jin-Hua Lin, Hai-Yan Wu, Xiao-Yu Wang, Hui Zhao, Shan-Shan Feng, Kyu-Sang Park, Dong-Qing Cai, Li Zheng, Xu-Feng Qi   +13 more
doaj   +1 more source

Potentiation effects of the positive allosteric modulator PTC‐174 on NMDA receptors in neonatal male rat substantia nigra dopaminergic neurons

British Journal of Pharmacology, Volume 183, Issue 21, Page 6481-6500, November 2026.
Abstract Background and Purpose Positive allosteric modulators bind to secondary binding sites on the receptor and alter receptor conformation and activation, changing agonist potency and efficacy. PTC‐174 is a novel NMDA receptor positive allosteric modulator that particularly enhances activity of receptors containing GluN2C or GluN2D subunits.
Bangyuan Liu, Alasdair J. Gibb
wiley   +1 more source

Wee1 kinase differentially regulates maize CDKA2;1a and CDKB1;1

The FEBS Journal, Volume 293, Issue 21, Page 6525-6551, November 2026.
In eukaryotes, Wee1 kinase inhibits the kinase activity of CDK/Cyc complexes through phosphorylation of a conserved residue in the CDK moiety. Wee1 is also present in plants, but has been scarcely studied. We have studied maize Wee1 regulation of CDKA/CycD2;2a or CDKB/CycD2;2a complexes.
Mingyar N. López‐Hernández, Estefany D. Guerrero‐Molina, Ulises Martínez‐Ortega, Aurora Lara‐Núñez, Jorge M. Vázquez‐Ramos   +4 more
wiley   +1 more source

Auxin response and PIN‐mediated transport in chlorophyte algae

Journal of Integrative Plant Biology, Volume 68, Issue 11, Page 3947-3961, November 2026.
Like multicellular plants, green algae respond to auxin and move it across their cells. However, their PIN‐like proteins do not act like plant auxin exporters, suggesting that basic auxin transport evolved early and specialized directional transport appeared later in plant evolution.
Adrijana Smoljan, Sarah Koutnik‐Abele, Dmitrii Vladimirtsev, Petr Klíma, Anita Bírošíková, Yuzhou Zhang, Jack Merrin, Maximilian Schuster, Katarina Kurtović, Ulrich Z. Hammes, Jan Petrášek, Jiří Friml   +11 more
wiley   +1 more source