Results 121 to 130 of about 93,386 (236)

Alternative Developmental Toxicity Screening Methods Using Chick Embryo‐Based Models

Journal of Applied Toxicology, Volume 46, Issue 8, Page 2640-2649, August 2026.
ABSTRACT Nonclinical developmental toxicity studies are used to investigate the potential toxicities of drugs and chemical candidates on normal embryonic and fetal development during pregnancy, generally using mammalian laboratory animals such as rats and rabbits.
Jeong Hwan Kim, Cheoljin Park, Donghee Kim, Wonjun Jeong, Jinsoo Lee   +4 more
wiley   +1 more source

Thermal and immunological stress modulate the locomotor performance of female <i>Xenopus laevis</i> frogs. [PDF]

Conserv Physiol
Oliveira TG, Araspin L, Cabanzo-Olarte LC, Navas CA, Herrel A.   +4 more
europepmc   +1 more source

Astrocytes in Genetic Epilepsies: Supporting Actor or Key Player?

Journal of Neuroscience Research, Volume 104, Issue 8, August 2026.
Astrocytes contribute to the pathophysiology of acquired epilepsy. However, less is known about their contribution to genetic epilepsy syndromes which often exhibit frequent comorbidity with neurodevelopmental and psychiatric disorders. Epileptic seizures are also frequently present in neurodevelopmental disorders.
Jenny Lange, Erica Zhao, Ellie O'Connell, Olivia Gillham, Amy McTague   +4 more
wiley   +1 more source

DAXX promotes SUMOylation of chromatin-trapped DNMT1. [PDF]

J Biochem
Tanimoto S, Wang TW, Yabushita T, Chiba Y, Konishi C, Endo A, Saeki Y, Goyama S, Nakanishi M, Nishiyama A.   +9 more
europepmc   +1 more source

Rare Biallelic CTU2 Variants in an Individual With CAKUT: Clinical Characterization and Minigene Splicing Analysis

Molecular Genetics &Genomic Medicine, Volume 14, Issue 8, August 2026.
Exome sequencing in 200 CAKUT patients identified compound heterozygous rare CTU2 variants in one renal‐predominant case. Minigene splicing assays showed c.913C>T partially increased exon 9 skipping, supporting further case collection and kidney‐relevant studies to clarify the role of CTU2 in renal developmental phenotypes.
Qian Liu, Xueqin Cheng, Bixia Zheng, Chunli Wang, Wei Zhou, Aihua Zhang   +5 more
wiley   +1 more source

A homozygous human WNT11 variant is associated with laterality, heart and renal defects

Disease Models & Mechanisms
Henrike Berns, Damian Weber, Maximilian Haas, Zeineb Bakey, Magdalena Maria Brislinger-Engelhardt, Miriam Schmidts, Peter Walentek   +6 more
doaj   +1 more source

Cadmium impairs heart ventricular formation and disrupts polysialylated-NCAM/FGF receptor signaling in Xenopus tadpoles. [PDF]

Cell Biosci
Douchez P, Fliniaux I, Takeda-Uchimura Y, Martoriati A, Marin M, Harduin-Lepers A, Cailliau K.   +6 more
europepmc   +1 more source

Evolutionary history and recombination in the mitochondrial carrier SLC25 superfamily analyzed by similarities in the exon and transmembrane α‐helix sequences

Protein Science, Volume 35, Issue 8, August 2026.
Abstract Mitochondrial carriers (MCs), which constitute a superfamily also called the solute carrier family 25 (SLC25), are characterized by conserved signature motif sequences and a six‐transmembrane α‐helical transporter domain. They transport a wide variety of substrates ranging from protons, inorganic ions, citric acid cycle intermediates, and ...
Magnus Monné, Daniela Valeria Miniero, Rosa Calvello, Antonia Cianciulli, Luigi Palmieri, Ferdinando Palmieri   +5 more
wiley   +1 more source

Histone Density and Dynamics Shape Mitotic Chromatid Architecture in Xenopus Egg Extracts. [PDF]

Genes Cells
Shintomi K, Ohsumi K, Iwabuchi M, Hirano T.   +3 more
europepmc   +1 more source

Could NAPQI Contribute to Paracetamol Analgesia? Redox Modulation of Kv7 Ion Channels

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
ABSTRACT Paracetamol (acetaminophen, APAP) is one of the most widely used analgesic and antipyretic drugs worldwide, yet its mechanism of action remains incompletely understood. While several pathways have been proposed, including cyclooxygenase inhibition and endocannabinoid modulation via AM404, none fully account for its pharmacological profile. The
Sara M‐Alicante, Janire Urrutia, Arantza Muguruza‐Montero, Miren Revuelta, Ane Arrizabalaga‐Iriondo, Alvaro Villarroel, Eider Nuñez   +6 more
wiley   +1 more source