Results 71 to 80 of about 137,536 (254)
microPublication BiologyIn Xenopus laevis, axial elongation beyond the tailbud stage requires gamma-aminobutyric acid (GABA). However, the role of GABA synthesized during early development in this process remains unclear. In this study, by treating embryos with allylglycine (AG)
Masaki Hachiman, Hiroki Kuroda
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Retinoic acid-activated Ndrg1a represses Wnt/β-catenin signaling to allow Xenopus pancreas, oesophagus, stomach, and duodenum specification. [PDF]
PLoS ONE, 2013 How cells integrate multiple patterning signals to achieve early endoderm regionalization remains largely unknown. Between gastrulation and neurulation, retinoic acid (RA) signaling is required, while Wnt/β-catenin signaling has to be repressed for the ...
Tiejun Zhang +2 more
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Zebrafish ventral gastrula fate map reveals neural crest progenitor domain
Developmental Dynamics, EarlyView.Abstract Background Fate maps relate progenitor cell positions to later fates and locations of their progeny, revealing early embryonic organization. Previous zebrafish fate maps identified the origin of germ layers and derivative cell fates, but ventral gastrula progenitor domains were not fully resolved. In particular, the neural crest, a multipotent
Elaine E. Kushkowski, Victoria E. Prince
wiley +1 more source
Genomic Complexity of ccdc40 in Xenopus: Implications for CRISPR Targeting and Disease Modeling
microPublication BiologyMutations in CCDC40 cause primary ciliary dyskinesia in humans. To evaluate the pathogenicity of variants in CCDC40, we examined the genomic structure of this gene in Xenopus tropicalis, a diploid frog suitable as a model for genetic studies.
Takuya Nakayama, Saurabh Kulkarni
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Developmental Dynamics, EarlyView.Abstract Neural crest cells are multipotent, migratory stem‐like cells essential for vertebrate development that contribute broadly to many tissues including the craniofacial skeleton, peripheral nervous system, and pigment‐producing cells. Their development progresses through phases of induction, specification, delamination, migration, and ...
Allison E. Mancini +2 more
wiley +1 more source
microPublication BiologyCross-species expression of proteins in mammalian cells and Xenopus oocytes remains a powerful strategy for functional studies. This can be facilitated by plasmids with dual promoters, enabling use in both systems without separate subcloning.
Li Guan +5 more
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On-Line Resources for Xenopus [PDF]
, 2012 Since the advent of computational methods in biology, the quantity of biological data has grown exponentially. These data support genomic, genetic, developmental, and other forms of biological experimentation. The number of on-line resources has kept pace with the growth in data.
openaire +2 more sources
Evidence for functional convergence between LZTS2 and DYRK1A during craniofacial development
Developmental Dynamics, EarlyView.Abstract Background Precise control of DYRK1A dosage is essential for embryonic development, including craniofacial morphogenesis. While LZTS2 is among the most consistently identified DYRK1A‐interacting proteins, its roles in embryonic development remain incompletely understood, and its potential contribution to craniofacial development has not been ...
Nicole Cheng +3 more
wiley +1 more source
Inbreeding ratio and genetic relationships among strains of the Western clawed frog, Xenopus tropicalis [PDF]
, 2015 The Western clawed frog, Xenopus tropicalis, is a highly promising model amphibian, especially in developmental and physiological research, and as a tool for understanding disease.
Atsushi Suzuki +33 more
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microPublication BiologyNeurogenic differentiation factor 2, encoded by the NEUROD2 gene, is a proneural transcription factor required for neuronal differentiation and survival.
Caroline W Beck +2 more
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