Results 11 to 20 of about 93,386 (236)

Age-associated DNA methylation changes in Xenopus frogs

open access: yesEpigenetics, 2023
Age-associated changes in DNA methylation have been characterized across various animals, but not yet in amphibians, which are of particular interest because they include widely studied model organisms.
Marco Morselli   +5 more
doaj   +1 more source

Xenopus Cdc7 executes its essential function early in S phase and is counteracted by checkpoint-regulated protein phosphatase 1 [PDF]

open access: yesOpen Biology, 2014
The initiation of DNA replication requires two protein kinases: cyclin-dependent kinase (Cdk) and Cdc7. Although S phase Cdk activity has been intensively studied, relatively little is known about how Cdc7 regulates progression through S phase.
Wei Theng Poh   +4 more
doaj   +1 more source

Xenopus Resources: Transgenic, Inbred and Mutant Animals, Training Opportunities, and Web-Based Support

open access: yesFrontiers in Physiology, 2019
Two species of the clawed frog family, Xenopus laevis and X. tropicalis, are widely used as tools to investigate both normal and disease-state biochemistry, genetics, cell biology, and developmental biology.
Marko Horb   +18 more
doaj   +1 more source

Developing immortal cell lines from Xenopus embryos, four novel cell lines derived from Xenopus tropicalis

open access: yesOpen Biology, 2022
The diploid anuran Xenopus tropicalis has emerged as a key research model in cell and developmental biology. To enhance the usefulness of this species, we developed methods for generating immortal cell lines from Nigerian strain (NXR_1018, RRID ...
Gary J. Gorbsky   +8 more
doaj   +1 more source

Temporal Relationship of Ocular and Tail Segmental Movements Underlying Locomotor-Induced Gaze Stabilization During Undulatory Swimming in Larval Xenopus

open access: yesFrontiers in Neural Circuits, 2018
In larval xenopus, locomotor-induced oculomotor behavior produces gaze-stabilizing eye movements to counteract the disruptive effects of tail undulation during swimming.
Julien Bacqué-Cazenave   +4 more
doaj   +1 more source

CRISPR/Cas9-Mediated Models of Retinitis Pigmentosa Reveal Differential Proliferative Response of Müller Cells between Xenopus laevis and Xenopus tropicalis

open access: yesCells, 2022
Retinitis pigmentosa is an inherited retinal dystrophy that ultimately leads to blindness due to the progressive degeneration of rod photoreceptors and the subsequent non-cell autonomous death of cones.
Karine Parain   +7 more
doaj   +1 more source

Lineage commitment of embryonic cells involves MEK1-dependent clearance of pluripotency regulator Ventx2

open access: yeseLife, 2017
During early embryogenesis, cells must exit pluripotency and commit to multiple lineages in all germ-layers. How this transition is operated in vivo is poorly understood.
Pierluigi Scerbo   +2 more
doaj   +1 more source

Generation and Care of Xenopus laevis and Xenopus tropicalis Embryos [PDF]

open access: yes, 2018
Robust and efficient protocols for fertilization and early embryo care of Xenopus laevis and Xenopus tropicalis are essential for experimental success, as well as maintenance and propagation of precious animal stocks. The rapid growth of the National Xenopus Resource has required effective implementation and optimization of these protocols.
Marcin, Wlizla   +2 more
openaire   +2 more sources

Dusp1 modulates activin/smad2 mediated germ layer specification via FGF signal inhibition in Xenopus embryos

open access: yesAnimal Cells and Systems, 2020
Activin, a member of the transforming growth factor (TGF-β) superfamily, induces mesoderm, endoderm and neuro-ectoderm formation in Xenopus embryos. Despite several previous studies, the complicated gene regulatory network and genes involved in this ...
Zobia Umair   +9 more
doaj   +1 more source

Reversible Thiol Oxidation Inhibits the Mitochondrial ATP Synthase in Xenopus Laevis Oocytes

open access: yesAntioxidants, 2020
Oocytes are postulated to repress the proton pumps (e.g., complex IV) and ATP synthase to safeguard mitochondrial DNA homoplasmy by curtailing superoxide production. Whether the ATP synthase is inhibited is, however, unknown.
James Cobley   +4 more
doaj   +1 more source

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