Results 21 to 30 of about 137,221 (140)
Xenopus pancreas development [PDF]
Developmental Dynamics, 2009 AbstractUnderstanding how the pancreas develops is vital to finding new treatments for a range of pancreatic diseases, including diabetes and pancreatic cancer.Xenopusis a relatively new model organism for the elucidation of pancreas development, and has already made contributions to the field.
Marko E. Horb +5 more
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Ataxia-telangiectasia Mutated (ATM)-dependent Activation of ATR Occurs through Phosphorylation of TopBP1 by ATM [PDF]
, 2007 ATM (ataxia-telangiectasia mutated) is necessary for activation of Chk1 by ATR (ATM and Rad3-related) in response to double-stranded DNA breaks (DSBs) but not to DNA replication stress. TopBP1 has been identified as a direct activator of ATR.
Dunphy, William G. +4 more
core +3 more sources
Cardiac regeneration in Xenopus tropicalis and Xenopus laevis: discrepancies and problems [PDF]
Cell & Bioscience, 2018 Two studies have recently focused on adult heart regeneration in Xenopus. While we reported on cardiac myogenic regeneration in Xenopus tropicalis after injury, Marshall and colleagues found no regeneration in an injured heart in Xenopus laevis. Here, we would like to join the discussion initiated by Marshall et al.
Souqi Liao +5 more
openaire +4 more sources
Current perspectives of the signaling pathways directing neural crest induction. [PDF]
, 2012 The neural crest is a migratory population of embryonic cells with a tremendous potential to differentiate and contribute to nearly every organ system in the adult body.
García-Castro, Martín I +1 more
core +2 more sources
Transposon transgenesis in Xenopus [PDF]
Methods, 2010 Transposon-mediated integration strategies in Xenopus offer simple and robust methods for the generation of germline transgenic animals. Co-injection of fertilized one-cell embryos with plasmid DNA harboring a transposon transgene and synthetic mRNA encoding the cognate transposase enzyme results in mosaic integration of the transposon at early ...
Donald Yergeau +4 more
openaire +3 more sources
Paradigm Shifts In Neural Induction [PDF]
, 2000 The molecularization of developmental biology was originally seen as a challenge to the integrity of that discipline. However, important new insights from the analysis of gene expression soon transformed the field from one of experimental anatomy to one ...
Gilbert, Scott F.
core +2 more sources
Cell Cycle Control by Xenopus p28^(Kix1) a Developmentally Regulated Inhibitor of Cyclin-dependent Kinases [PDF]
, 1996 We have isolated Xenopus p28^(Kix1), a member of the p21^(CIP1)/p27^(KIP1)/p57^(KIP2) family of cyclin-dependent kinase (Cdk) inhibitors. Members of this family negatively regulate cell cycle progression in mammalian cells by inhibiting the activities of
Dunphy, William G., Shou, Wenying
core
Chromatin immunoprecipitation and deep sequencing in Xenopus tropicalis and Xenopus laevis [PDF]
Methods, 2014 Chromatin immunoprecipitation and deep sequencing (ChIP-SEQ) represents a powerful tool for identifying the genomic targets of transcription factors, chromatin remodeling factors, and histone modifications. The frogs Xenopus laevis and Xenopus tropicalis have historically been outstanding model systems for embryology and cell biology, with emerging ...
Edward B. Chuong +3 more
openaire +3 more sources
INTACT Proteomics in Xenopus [PDF]
Cold Spring Harbor Protocols, 2018 Analysis of the molecular mechanisms driving cell specification, differentiation, and other cellular processes can be difficult due to the heterogeneity of tissues and organs. Therefore, it is critical to isolate pure cell populations in order to properly assess the function of certain cell types in the context of a tissue.
Frank L. Conlon +2 more
openaire +2 more sources
Metamodulation of a spinal locomotor network by nitric oxide [PDF]
, 2004 Flexibility in the output of spinal networks can be accomplished by the actions of neuromodulators; however, little is known about how the process of neuromodulation itself may be modulated.
McLean, DL, Sillar, Keith Thomas
core +1 more source