Results 91 to 100 of about 92,026 (241)

Protocol to study human Kv1.2 potassium channel pathogenic sequence variants using two-electrode voltage-clamp technique

STAR Protocols
Summary: The abietane diterpenoid pisiferic acid (PA) from conifer Chamaecyparis pisifera is a pan-rescuer of human Kv1.2 channel pathogenic loss-of-function (LOF) sequence variants.
Rían W. Manville, Geoffrey W. Abbott
doaj   +1 more source

DEADSouth protein localizes to germ plasm and is required for the development of primordial germ cells in Xenopus laevis

Biology Open, 2012
Summary DEADSouth mRNA is a component of germ plasm in Xenopus laevis and encodes a DDX25 DEAD-box RNA helicase. To determine the intracellular localization of DEADSouth protein, we injected mRNA encoding DEADSouth tagged with mCherry fluorescent protein
Takeshi Yamaguchi, Ayaka Taguchi, Kenji Watanabe, Hidefumi Orii   +3 more
doaj   +1 more source

Toxicity of Four Common Environmental Chemicals Across Caenorhabditis elegans Life Stages Supporting the One Health Concept

Environmental Toxicology, EarlyView.
ABSTRACT Pesticides and pharmaceuticals are among the most common chemical groups in waterbodies and soils, and their universal distribution raises concerns about potential adverse effects on nontarget organisms and humans. Reproductive output disruption is of particular concern, as it transposes effects from the individual to the next generations at ...
Fábio Campos, Maria D. Pavlaki, Amadeu M. V. M. Soares, Susana Loureiro   +3 more
wiley   +1 more source

XenDB: Full length cDNA prediction and cross species mapping in Xenopus laevis

BMC Genomics, 2005
Background Research using the model system Xenopus laevis has provided critical insights into the mechanisms of early vertebrate development and cell biology. Large scale sequencing efforts have provided an increasingly important resource for researchers.
Giegerich Robert, Brivanlou Ali H, Beckstette Michael, Sczyrba Alexander, Altmann Curtis R   +4 more
doaj   +1 more source

Kinetic model of DNA replication in eukaryotic organisms

, 2003
We formulate a kinetic model of DNA replication that quantitatively describes recent results on DNA replication in the in vitro system of Xenopus laevis prior to the mid-blastula transition.
Avrami, Avrami, Avrami, Ben-Naim, Bensimon, Berezney, Blow, Blow, Blow, Blow, Blumenthal, Brewer, Buongiorno-Nardelli, Cahn, Cairns, Christian, Coverley, Friedman, Gilbert, Gomez, Hand, Herrick, Herrick, Huberman, Hyrien, Jackson, Jasny, Johnson, Kolmogorov, Laskey, Lu, Lucas, Mahbubani, Marheineke, Michalet, Mills, Pasero, Pierron, Plischke, Press, Raghuraman, Rowles, Sekimoto, Shinomiya, Shivashankar, Simon, Walter, Wu   +47 more
core   +1 more source

Metamodulation of a spinal locomotor network by nitric oxide [PDF]

, 2004
Flexibility in the output of spinal networks can be accomplished by the actions of neuromodulators; however, little is known about how the process of neuromodulation itself may be modulated.
McLean, DL, Sillar, Keith Thomas
core   +1 more source

The amino terminal domain of the human α7 nicotinic acetylcholine receptor subunit leads to the functional expression of human/insect receptors

British Journal of Pharmacology, EarlyView.
Human α7 receptors have been characterised in terms of pharmacological properties. Insertion of the N‐terminal domain of the human α7 subunit leads to honeybee and cockroach chimeric receptors activated by ACh and inhibited by α‐Bgt. Insertion of the human cys‐loop leads to cockroach chimeric receptors modulated by PNU.
Alison Cartereau, Chloé Veront, Alexandra Cremades, Priscilla Martin, Remi Gojard, Nicolas Galland, Emiliane Taillebois, Dieudonnée Togbé, Jean‐Yves Le Questel, Steeve H. Thany   +9 more
wiley   +1 more source

Association of TCTP with Centrosome and Microtubules

Biochemistry Research International, 2012
Translationally Controlled Tumour Protein (TCTP) associates with microtubules (MT), however, the details of this association are unknown. Here we analyze the relationship of TCTP with MTs and centrosomes in Xenopus laevis and mammalian cells using ...
Mariusz K. Jaglarz, Franck Bazile, Katarzyna Laskowska, Zbigniew Polanski, Franck Chesnel, Ewa Borsuk, Malgorzata Kloc, Jacek Z. Kubiak   +7 more
doaj   +1 more source

Xenopus laevis as a Model Organism for the Study of Spinal Cord Formation, Development, Function and Regeneration

Frontiers in Neural Circuits, 2017
The spinal cord is the first central nervous system structure to develop during vertebrate embryogenesis, underscoring its importance to the organism. Because of its early formation, accessibility to the developing spinal cord in amniotes is challenging,
Laura N. Borodinsky
doaj   +1 more source

Kaiso is a genome-wide repressor of transcription that is essential for amphibian development [PDF]

, 2004
DNA methylation in animals is thought to repress transcription via methyl-CpG specific binding proteins, which recruit enzymatic machinery promoting the formation of inactive chromatin at targeted loci.
Dunican, Donncha S, Meehan, Richard R, Pennings, Sari, Prokhortchouk, Anna, Prokhortchouk, Egor, Ruzov, Alexey, Stancheva, Irina   +6 more
core   +1 more source