Results 81 to 90 of about 41,241 (205)

Xenopus laevis neural stem progenitor cells exhibit a transient metabolic shift toward glycolysis during spinal cord regeneration

Frontiers in Cell and Developmental Biology
Spinal cord injury (SCI) results in severe disruption of communication between the brain and body, causing motor, sensory, and autonomic dysfunctions. While SCI in mammals leads to permanent impairment due to limited regenerative capacity, certain non ...
Paula G. Slater, Paula G. Slater, Miguel E. Domínguez-Romero, Guillermo Campos, Guillermo Campos, Vania Aravena, Vania Aravena, Javier Cavieres-Lepe, Verónica Eisner   +8 more
doaj   +1 more source

Histone H3K79 methyltransferase Dot1L is directly activated by thyroid hormone receptor during Xenopus metamorphosis

Cell & Bioscience, 2012
Background Thyroid hormone (T3) is important for adult organ function and vertebrate development. Amphibian metamorphosis is totally dependent on T3 and offers a unique opportunity to study how T3 controls postembryonic development in vertebrates ...
Matsuura Kazuo, Fujimoto Kenta, Das Biswajit, Fu Liezhen, Lu Christopher D, Shi Yun-Bo   +5 more
doaj   +1 more source

Functional screen for subtype specificity of voltage sensor–targeted Kv7 potentiators

British Journal of Pharmacology, Volume 183, Issue 17, Page 5372-5388, September 2026.
Background and Purpose Voltage‐gated Kv7 (potassium channel subfamily Q [KCNQ]) potassium channels are powerful modulators of neuronal excitability. ICA‐069673 is a N‐aryl benzamide drug that targets the voltage‐sensing domain (VSD) of Kv7.2 with strong selectivity over Kv7.3 or Kv7.5, but the molecular basis of this selectivity remains poorly ...
Richard Kanyo, Thomas M. Hammond, Alice W. Wang, Caroline K. Wang, Varun Aggarwal, Shawn M. Lamothe, Harley T. Kurata   +6 more
wiley   +1 more source

Optimization of novel compounds using computer‐aided drug design for treatment of cardiac arrhythmia

British Journal of Pharmacology, Volume 183, Issue 17, Page 5407-5420, September 2026.
Background and Purpose Loss‐of‐function mutations of the voltage‐gated Kv7.1 (KCNQ/KCNE1) channels lead to cardiac arrhythmia such as long QT syndrome, characterized by a prolonged QT interval . One strategy to correct the prolonged QT interval is to design molecules that activate KCNQ1/KCNE1 channels and restore the QT interval.
Jessica Jowais, Laura M. Castro‐Gonzalez, Alessia Golluscio, D. Peter Tieleman, H. Peter Larsson   +4 more
wiley   +1 more source

Antipredatory Strategies of Anurans: An Updated Conceptual Review

Ethology, Volume 132, Issue 9, Page 662-708, September 2026.
To unravel the evolutionary dynamics of predator–prey interactions, we propose an updated, three‐tiered classification of anuran antipredatory strategies. By mapping non‐behavioral, individual, and group defenses across five functional phases, this integrative framework introduces the concept of synergetic coupling.
Ubiratã Ferreira Souza, Lucas Rosado Mendonça, Carlos Jared, L. Felipe Toledo   +3 more
wiley   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, Volume 16, Issue 8, Page 1477-1490, August 2026.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Divergent roles of the Wnt/PCP Formin Daam1 in renal ciliogenesis.

PLoS ONE, 2019
Kidneys are composed of numerous ciliated epithelial tubules called nephrons. Each nephron functions to reabsorb nutrients and concentrate waste products into urine.
Mark E Corkins, Vanja Krneta-Stankic, Malgorzata Kloc, Pierre D McCrea, Andrew B Gladden, Rachel K Miller   +5 more
doaj   +1 more source

The ageing holobiont: crosstalk between telomere dynamics, oxidative stress and the gut microbiome

Biological Reviews, Volume 101, Issue 4, Page 1877-1903, August 2026.
ABSTRACT The gut tissue is at the frontline of early onset of ageing. It exhibits high cell turnover rates and rapid telomere shortening, which can have systemic effects on the developing or senescing organism. We conducted a literature review of studies on the crosstalk between telomere length dynamics, telomerase activity, oxidative stress, and gut ...
Michael L. Pepke, Søren B. Hansen, Morten T. Limborg   +2 more
wiley   +1 more source

Astrocytes in Genetic Epilepsies: Supporting Actor or Key Player?

Journal of Neuroscience Research, Volume 104, Issue 8, August 2026.
Astrocytes contribute to the pathophysiology of acquired epilepsy. However, less is known about their contribution to genetic epilepsy syndromes which often exhibit frequent comorbidity with neurodevelopmental and psychiatric disorders. Epileptic seizures are also frequently present in neurodevelopmental disorders.
Jenny Lange, Erica Zhao, Ellie O'Connell, Olivia Gillham, Amy McTague   +4 more
wiley   +1 more source

The Pharmacology of the SLC15A4‐TASL Complex, an Emerging Target for the Treatment of Lupus

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
ABSTRACT SLC15A4 is a member of the solute carrier superfamily that has been strongly linked to the pathogenesis of the auto‐immune disease SLE. The endo‐lysosomally localized SLC15A4 has traditionally been considered a proton‐dependent histidine and peptide transporter, but has also been shown to facilitate TLR7, 8, and 9 induced IFN‐alpha signaling ...
Alex L. Wilkinson, Dillon Popat, Kathy Sengmany, Miguel C. Silva, Steven J. Charlton, Charles S. Lay   +5 more
wiley   +1 more source