Results 101 to 110 of about 92,026 (241)
Functional screen for subtype specificity of voltage sensor–targeted Kv7 potentiators
British Journal of Pharmacology, EarlyView.Background and Purpose Voltage‐gated Kv7 (potassium channel subfamily Q [KCNQ]) potassium channels are powerful modulators of neuronal excitability. ICA‐069673 is a N‐aryl benzamide drug that targets the voltage‐sensing domain (VSD) of Kv7.2 with strong selectivity over Kv7.3 or Kv7.5, but the molecular basis of this selectivity remains poorly ...
Richard Kanyo +6 more
wiley +1 more source
Development of Antimicrobial Peptides from Amphibians
Antibiotics, 2020 Since the discovery of magainins from the skin secretions of the African toad Xenopus laevis by Michael Zasloff in 1987, an increasing number of antimicrobial peptides (AMPs) has been identified in different anuran species and studied in detail [...]
Maria Luisa Mangoni, Bruno Casciaro
doaj +1 more source
Cell Proliferation, Volume 59, Issue 6, June 2026.The endoplasmic reticulum membrane protein complex (EMC) is an evolutionarily conserved, multi‐subunit transmembrane protein complex crucial to membrane protein biogenesis and cellular protein quality control. This review systematically examines the structure, functions and disease‐associated regulatory mechanisms of EMC across multiple organ systems ...
Yan Qiao +6 more
wiley +1 more source
Early Head Specification in Xenopus laevis
The Scientific World Journal, 2003 The head represents the most dorsal and anterior extent of the body axis. In Xenopus, the progressive determination of the head is an extremely complex process involving the activation and localized antagonism of a number of interdependent intracellular ...
Blue B. Lake, Kenneth R. Kao
doaj +1 more source
Migratory and adhesive properties of Xenopus laevis primordial germ cells in vitro
Biology Open, 2013 Summary The directional migration of primordial germ cells (PGCs) to the site of gonad formation is an advantageous model system to study cell motility.
Aliaksandr Dzementsei +3 more
doaj +1 more source
Cell motility driving mediolateral intercalation in explants of Xenopus laevis [PDF]
, 1992 In Xenopus, convergence and extension are produced by active intercalation of the deep mesodermal cells between one another along the mediolateral axis (mediolateral cell intercalation), to form a narrower, longer array.
Keller, Ray, Shih, John
core
The FEBS Journal, EarlyView.We investigated the potential of iloperidone as an activator of Sigma‐1 receptor (S1R) neuroprotective function in juvenile Huntington's disease (jHD). We tested iloperidone on cortical neurons differentiated from patient‐derived iPSCs, demonstrating that it acts as a S1R agonist, decreasing apoptosis, huntingtin aggregation, and oxidative stress ...
Ersilia Fornetti +11 more
wiley +1 more source
The Many Faces of Xenopus: Xenopus laevis as a Model System to Study Wolf–Hirschhorn Syndrome
Frontiers in Physiology, 2019 Wolf–Hirschhorn syndrome (WHS) is a rare developmental disorder characterized by intellectual disability and various physical malformations including craniofacial, skeletal, and cardiac defects.
Micaela Lasser +4 more
doaj +1 more source
Generation and Care of Xenopus laevis and Xenopus tropicalis Embryos [PDF]
, 2018 Robust and efficient protocols for fertilization and early embryo care of Xenopus laevis and Xenopus tropicalis are essential for experimental success, as well as maintenance and propagation of precious animal stocks. The rapid growth of the National Xenopus Resource has required effective implementation and optimization of these protocols.
Marcin, Wlizla +2 more
openaire +2 more sources
Wee1 kinase differentially regulates maize CDKA2;1a and CDKB1;1
The FEBS Journal, EarlyView.In eukaryotes, Wee1 kinase inhibits the kinase activity of CDK/Cyc complexes through phosphorylation of a conserved residue in the CDK moiety. Wee1 is also present in plants, but has been scarcely studied. We have studied maize Wee1 regulation of CDKA/CycD2;2a or CDKB/CycD2;2a complexes.
Mingyar N. López‐Hernández +4 more
wiley +1 more source