Results 121 to 130 of about 91,354 (252)

Functional characterization of a glutamate/aspartate transporter from the mosquito Aedes aegypti [PDF]

, 2003
Glutamate elicits a variety of effects in insects, including inhibitory and excitatory signals at both neuromuscular junctions and brain. Insect glutamatergic neurotransmission has been studied in great depth especially from the standpoint of the ...
Cohen, Bruce N., Gill, Sarjeet S., Ross, Linda S., Umesh, Anita   +3 more
core  

Memantine treatment in individuals with GRIN gain‐of‐function variants is associated with improvements in behavior, development, and seizure frequency

Epilepsia, Volume 67, Issue 4, Page 1961-1974, April 2026.
Abstract Objective GRIN‐related disorders due to pathogenic variants in GRIN1, GRIN2A, GRIN2B, or GRIN2D genes are associated with altered N‐methyl‐D‐aspartate receptor (NMDAR) function. Functional changes include gain (GoF) and loss of receptor function (LoF). Clinical reports describing the use of the NMDAR blocker memantine in GRIN‐related disorders
Maike Karnstedt, Riley E. Perszyk, Scott J. Myers, Ellington McDaniels, Marta Somorai, Ingo Borggraefe, Danielle C. M. Veenma, An‐Sofie Schoonjans, Pasquale Striano, Tadeu A. Fantaneanu, Steffen Syrbe, Kristen Park, Wenjuan Chen, Hongjie Yuan, Stephen F. Traynelis, Timothy A. Benke, Johannes R. Lemke, Ilona Krey   +17 more
wiley   +1 more source

Predictive value of seizure onset for gross motor dysfunction in individuals with pathogenic GABRB2 and GABRB3 variants

Epilepsia, Volume 67, Issue 4, Page 1945-1960, April 2026.
Abstract Objective Pathogenic variants in γ‐aminobutyric acid type A (GABAA) receptor genes have been associated with a wide spectrum of neurological disorders. We aimed to delineate the clinical trajectories associated with gain‐of‐function (GoF) and loss‐of‐function (LoF) variants in GABRB2 and GABRB3, and to develop a risk‐prediction model for gross
Sebastian Ortiz, Leonardo Affronte, Chiara Bagliani, Serene El‐Kamand, Anthony Sze Hon Kan, Isabel T. Kristoffersen, Rebekka S. Dahl, Anne F. Højte, Stéphane Auvin, Arjan Bouman, Shimriet Zeidler, Gerhard Kluger, Gaetan Lesca, Nicolas Chatron, Zeynep Goke‐Samar, Maria T. Papadopoulou, Matthildi Athina Papathanasiou Terzi, Elise Schaefer, Anne de Saint Martin, Sarah Baer, Mohammed Al Owain, Saud Takroni, Hesham Al‐Dhalaan, Paolo Bonanni, Alessandra Rossi, Nicoletta Zanotta, Marina Trivisano, Nicola Specchio, Angela de Dominicis, Pasquale Striano, Alessandro Orsini, Maria Margherita Mancardi, Sebastian Neuens, Melanie Jennesson‐Lyver, Ira Benkel‐Herrenbrueck, David Genevieve, Richard Sidlow, Kamer Tezcan, Ilona Krey, Johannes R. Lemke, Konrad Platzer, Damien Lederer, Inga Talvik, Ulvi Vaher, Kees P. J. Braun, Anne‐Marie Guerrot, Rebecca More, Matthias De Wachter, Sarah Weckhuysen, Evelina Carapancea, Maria Roberta Cilio, Julia Jacobs, Katalin Sterbova, Simona Balestrini, Renzo Guerrini, Giulio Peroni, Inger‐Lise Mero, Walaa ElNaggar, Nour Elkhateeb, Ariane Schmetz, Denise L. Chan, Ghayda M. Mirzaa, Boris Chaumette, Adrien Legrand, Amy McTague, Tommy Stödberg, Rebekah V. Harris, Samuel F. Berkovic, Ingrid E. Scheffer, Mary Chebib, Elena Gardella, Philip K. Ahring, Nathan L. Absalom, Rikke S. Møller   +73 more
wiley   +1 more source

The Individual and Combined Effects of Warming and Atrazine on Lithobates pipiens Phenotypes: Implications for Frog Declines

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, Volume 345, Issue 3, Page 238-258, April 2026.
ABSTRACT Amphibians are the most threatened vertebrate class globally. Climate change, agrochemicals, and/or pathogens and parasites are implicated in contributing to amphibian declines, either singly or in combination. We investigated individual and combined effects of elevated temperatures and atrazine (2.0 μg/L) on Lithobates [formerly Rana] pipiens
Melody J. Gavel, Mark R. Forbes, Derek D. N. Smith, Julia Darabaner, Yol Monica Reyes, Zintis Stasko, David J. Carpenter, Stacey A. Robinson   +7 more
wiley   +1 more source

Distribution of tissue progenitors within the shield region of the zebrafish gastrula [PDF]

, 1995
The zebrafish has emerged as an important model system for the experimental analysis of vertebrate development because it is amenable to genetic analysis and because its optical clarity allows the movements and the differentiation of individual cells to ...
Fraser, Scott E., Shih, John
core  

Glutathione Impacts Both Batrachochytrium dendrobatidis Virulence and Amphibian Cellular Defense in a Chytridiomycosis Model

MicrobiologyOpen, Volume 15, Issue 2, April 2026.
Glutathione shapes interactions between Batrachochytrium dendrobatidis (Bd) and amphibian hosts. In Bd, glutathione reductase is essential for survival, and exogenous glutathione enhances zoospore release. In host cells, Bd infection depletes glutathione and increases oxidative stress.
Rebecca J. Webb, Alexandra A. Roberts, Lee Berger, Jacques Robert, Lee F. Skerratt   +4 more
wiley   +1 more source

Characterizing the zebrafish organizer: microsurgical analysis at the early-shield stage [PDF]

, 1996
The appearance of the embryonic shield, a slight thickening at the leading edge of the blastoderm during the formation of the germ ring, is one of the first signs of dorsoventral polarity in the zebrafish embryo.
Fraser, Scott E., Shih, John
core  

Sex‐Specific Gene Expression Ontogeny During Gonadal Development in Post‐Metamorphic Xenopus tropicalis

Molecular Reproduction and Development, Volume 93, Issue 4, April 2026.
Post‐metamorphic gonadal development in Xenopus tropicalis was analyzed through integrated morphometric, histological, and transcriptional approaches. Males showed upregulation of cyp17, amh, and amhr2, whereas females exhibited an increased aldh1a2 and ddx4.
Daniele Marini, Mauricio Roza, Cecilia Berg, Vanessa Brouard   +3 more
wiley   +1 more source

Genome‐Wide Characterization of Sex‐Linked Regions in the Sangzhi Horned Toad (Boulenophrys sangzhiensis) Reveals Complex Sex Determination Mechanisms

Molecular Ecology Resources, Volume 26, Issue 3, April 2026.
ABSTRACT Sex chromosomes in amphibians exhibit substantial variability and often remain largely homomorphic, providing a powerful system for studying sex determination. The Sangzhi horned toad (Boulenophrys sangzhiensis) is an ideal model, but limited genomic resources have hindered insights into sex determination mechanisms.
Chun H. Huang, Si Y. Xie, Jun Li, Wan Y. Chen, Fu Y. Qiu, Mian Zhao, Wei Liu, Chun L. Liao, Hua Wu   +8 more
wiley   +1 more source

Integration of epigenetics into ecotoxicology: insights and fundamental research needs

Biological Reviews, Volume 101, Issue 2, Page 826-847, April 2026.
ABSTRACT Epigenetics refers to heritable changes in genome function that occur without direct alterations to the DNA sequence. A multitude of environmental contaminants can influence the epigenetic marks of a genome. Changes of epigenetic marks including DNA methylation, histone modifications, and non‐coding RNAs can induce alterations at the gene ...
Albano Pinto, Jana Asselman, Patrícia Pereira, Joana Luísa Pereira   +3 more
wiley   +1 more source