Results 1 to 10 of about 9,272 (178)

Echocardiographic assessment of Xenopus tropicalis heart regeneration [PDF]

Cell & Bioscience, 2023
Background Recently, it was reported that the adult X. tropicalis heart can regenerate in a nearly scar-free manner after injury via apical resection. Thus, a cardiac regeneration model in adult X. tropicalis provides a powerful tool for recapitulating a
Luocheng Lv, Weimin Guo, Wei Guan, Yilin Chen, Ruijin Huang, Ziqiang Yuan, Qin Pu, Shanshan Feng, Xin Zheng, Yanmei Li, Luanjuan Xiao, Hui Zhao, Xufeng Qi, Dongqing Cai   +13 more
doaj   +4 more sources

Developing immortal cell lines from Xenopus embryos, four novel cell lines derived from Xenopus tropicalis [PDF]

Open Biology, 2022
The diploid anuran Xenopus tropicalis has emerged as a key research model in cell and developmental biology. To enhance the usefulness of this species, we developed methods for generating immortal cell lines from Nigerian strain (NXR_1018, RRID ...
Gary J. Gorbsky, John R. Daum, Hem Sapkota, Katja Summala, Hitoshi Yoshida, Constantin Georgescu, Jonathan D. Wren, Leonid Peshkin, Marko E. Horb   +8 more
doaj   +3 more sources

Evolutionary divergence in tail regeneration between Xenopus laevis and Xenopus tropicalis [PDF]

Cell & Bioscience, 2021
Tissue regeneration is of fast growing importance in the development of biomedicine, particularly organ replacement therapies. Unfortunately, many human organs cannot regenerate.
Shouhong Wang, Yun-Bo Shi
doaj   +5 more sources

Modelling human genetic disorders in Xenopus tropicalis

Disease Models & Mechanisms
ABSTRACT Recent progress in human disease genetics is leading to rapid advances in understanding pathobiological mechanisms. However, the sheer number of risk-conveying genetic variants being identified demands in vivo model systems that are amenable to functional analyses at scale. Here we provide a practical guide for using the diploid
Helen Rankin Willsey, Eleanor G. Seaby, Annie Godwin, Sarah Ennis, Matthew Guille, Robert M. Grainger   +5 more
doaj   +4 more sources

CRISPR/Cas-mediated mRNA knockdown in the embryos of Xenopus tropicalis [PDF]

Cell & Bioscience
The Xenopus tropicalis (Western clawed frog) is an important amphibian model for genetics, developmental and regenerative biology, due to its diploid genetic background and short generation time.
Xiao-Lin Lin, Yi-Min Zhou, Ke Meng, Jia-Yi Yang, Han Zhang, Jin-Hua Lin, Hai-Yan Wu, Xiao-Yu Wang, Hui Zhao, Shan-Shan Feng, Kyu-Sang Park, Dong-Qing Cai, Li Zheng, Xu-Feng Qi   +13 more
doaj   +2 more sources

CRISPR/Cas9-Mediated Models of Retinitis Pigmentosa Reveal Differential Proliferative Response of Müller Cells between Xenopus laevis and Xenopus tropicalis [PDF]

Cells, 2022
Retinitis pigmentosa is an inherited retinal dystrophy that ultimately leads to blindness due to the progressive degeneration of rod photoreceptors and the subsequent non-cell autonomous death of cones.
Karine Parain, Sophie Lourdel, Alicia Donval, Albert Chesneau, Caroline Borday, Odile Bronchain, Morgane Locker, Muriel Perron   +7 more
doaj   +2 more sources

Cardiomyocyte proliferation and heart regeneration in adult Xenopus tropicalis evidenced by a transgenic reporter line [PDF]

npj Regenerative Medicine
Cardiomyocyte proliferation in adult Xenopus tropicalis during heart regeneration has remained largely contentious due to the absence of genetic evidence.
Xiao-Lin Lin, Jin-Hua Lin, Yan Cao, Han Zhang, Si-Yi He, Hai-Yan Wu, Ze-Bing Ye, Li Zheng, Xu-Feng Qi   +8 more
doaj   +2 more sources

Identification of tumor-related genes via RNA sequencing of tumor tissues in Xenopus tropicalis [PDF]

Scientific Reports, 2023
Cancer treatment is still challenging because the disease is often caused by multiple mutations. Although genomic studies have identified many oncogenes and tumor suppressor genes, gene sets involved in tumorigenesis remain poorly understood.
Kazuki Kitamura, Takayoshi Yamamoto, Haruki Ochi, Makoto Suzuki, Nanoka Suzuki, Takeshi Igawa, Tadashi Yoshida, Mitsuru Futakuchi, Hajime Ogino, Tatsuo Michiue   +9 more
doaj   +2 more sources

An epigenetic clock for Xenopus tropicalis. [PDF]

NPJ Aging
Abstract DNA methylation clocks have been widely used for accurate age prediction, but most studies have been carried out on mammals. Here we present an epigenetic clock for the aquatic frog Xenopus tropicalis, a widely used model organism in developmental biology and genomics.
Bennett R, Morselli M, Petrova K, Peshkin L, Pellegrini M.   +4 more
europepmc   +3 more sources

Melanin deposition and key molecular features in Xenopus tropicalis oocytes [PDF]

BMC Biology
Background Melanin pigmentation in oocytes is a critical feature for both the esthetic and developmental aspects of oocytes, influencing their polarity and overall development.
Hongyang Yi, Weizheng Liang, Sumei Yang, Han Liu, Jiayu Deng, Shuhong Han, Xiaohui Feng, Wenjie Cheng, Yonglong Chen, Jing Hang, Hongzhou Lu, Rensen Ran   +11 more
doaj   +2 more sources