Results 41 to 50 of about 787 (112)

Unexpected Cervical Lymph Node Metastasis Revealing TFE3‐Rearranged Renal Cell Carcinoma: Intraoperative Cytologic Clues to an Occult Renal Primary

Diagnostic Cytopathology, Volume 54, Issue 7, Page 538-541, July 2026.
ABSTRACT TFE3‐rearranged renal cell carcinoma (TFE3‐rRCC) is a rare subtype of renal carcinoma that may present diagnostic challenges in cytologic specimens, particularly when metastatic disease represents the initial clinical manifestation. We report the case of a 72‐year‐old man presenting with bulky cervical lymphadenopathy clinically suspicious for
Marc P. Pusztaszeri
wiley   +1 more source

Emerging Role of ctDNA Fragmentomics and Epigenetic Signatures in the Early Detection, Minimal Residual Disease Assessment, and Precision Monitoring of Renal Cell Carcinoma

Journal of Cellular and Molecular Medicine, Volume 30, Issue 3, February 2026.
ABSTRACT Renal cell carcinoma (RCC) presents a significant global health challenge, with a substantial proportion of patients diagnosed with advanced or metastatic disease due to the limitations of current diagnostic imaging and the lack of validated non‐invasive biomarkers.
Hossam Kamli, Najeeb Ullah Khan
wiley   +1 more source

Pregnant patient with Xp11.2/transcription factor E3 translocation renal cell carcinoma: a case report and literature review

Frontiers in Oncology
MiT family translocation renal cell carcinomas (tRCCs) primarily include Xp11.2/transcription factor E3 (TFE3) gene fusion-associated renal cell carcinoma (Xp11.2 tRCC) and t(6;11)/TFEB gene fusion-associated RCC.
Yanchen Wang, Xiaoyan Guo, Zhe Meng, Yong Cui, Yaofei Sun   +4 more
doaj   +1 more source

Recent developments in eosinophilic renal neoplasms: what's new, true and important?

Histopathology, Volume 88, Issue 1, Page 166-192, January 2026.
Recent developments and acquired knowledge on newer renal entities with eosinophilic cytoplasm opened insights into the clinical, pathological, immunohistochemical, molecular, epidemiological aspects, and the prognosis of these entities. We emphasize the role of routine morphology, aided by appropriate and select immunohistochemistry, as essential keys
Kiril Trpkov, Farshid Siadat, Rola Saleeb   +2 more
wiley   +1 more source

Xp11.2 translocation renal cell carcinoma occurring during pregnancy with a novel translocation involving chromosome 19: a case report with review of the literature

Diagnostic Pathology, 2009
The recently recognized renal cell carcinomas (RCCs) associated with Xp11.2 translocations (TFE3 transcription factor gene fusions) are rare tumors predominantly reported in children.
Surti Urvashi, Parwani Anil V, Armah Henry B, Bastacky Sheldon I   +3 more
doaj   +1 more source

Remarkable Response to Immunotherapy and VEGFR Inhibitor in Xp11 Translocation Renal Cell Carcinoma in a 17‐Year‐Old Adolescent

Case Reports in Medicine, Volume 2026, Issue 1, 2026.
Background Xp11 translocation renal cell carcinoma (tRCC) is a rare and aggressive renal cancer characterized by gene fusion involving TFE3. It accounts for < 5% of renal cancers and shows variable responses to conventional antivascular endothelial growth factor therapies.
Piyarat Limpawittayakul, Narongchai Teerayathanakul, Farid Cherbal   +2 more
wiley   +1 more source

A Rare Case of TFE3‐Rearranged and SMARCB1‐Mutated Renal Cell Carcinoma: Diagnostic and Therapeutic Complexities

Case Reports in Oncological Medicine, Volume 2026, Issue 1, 2026.
Renal cell carcinoma (RCC) represents the majority of kidney malignancies, with clear cell RCC being the most common subtype. However, recent advances in tumor genomics have refined RCC classification, highlighting rare molecular subtypes such as TFE3‐rearranged and SMARCB1‐deficient RCCs.
Paul J. Pecorin, Nyembezi Dhliwayo, Trevor Christ, Thomas Westbrook, Harleen Khatra   +4 more
wiley   +1 more source

PRCC-TFE3 dual-fusion FISH assay: A new method for identifying PRCC-TFE3 renal cell carcinoma in paraffin-embedded tissue. [PDF]

PLoS ONE, 2017
PRCC-TFE3 renal cell carcinoma (RCC) is one of the most common types of Xp11.2 translocation renal cell carcinoma (tRCC), of which the diagnosis mainly relies on reverse transcription-polymerase chain reaction (RT-PCR) or chromosomal analysis in fresh ...
Lei Xiong, Xiancheng Chen, Ning Liu, Zhen Wang, Baolei Miao, Weidong Gan, Dongmei Li, Hongqian Guo   +7 more
doaj   +1 more source

The Role of Glycoprotein Non‐Metastatic Melanoma Protein B (GPNMB) in Tumors and Other Diseases

MedComm – Oncology, Volume 4, Issue 3, September 2025.
Glycoprotein non‐metastatic melanoma protein B (GPNMB) is is widely involved in biological processes such as tissues, cells, metabolism and immunity, regulates multiple signaling pathways, and plays an important role in the occurrence and development of various diseases, including tumors.
Zhenyu Wu, Na Sun, Man Qu, Xia Kang, Yi Zhang, Xiaowei Qi   +5 more
wiley   +1 more source

Case Reports of TFE3-Rearranged Renal Cell Carcinoma: FDG-PET Uptake Might Help Diagnosis

Journal of Kidney Cancer and VHL, 2023
Translocation and transcription factor E3 (TFE3)-rearranged renal cell carcinoma (RCC) is a rare subtype of RCCs characterised by the fusion of the TFE3 transcription factor genes on chromosome Xp11.2 with one of the multiple genes.
Sho Murakami, Keita Nagawa, Takanori Inui, Aya Yamamoto, Mizuka Suzuki, Fumitaka Koga, Toru Motoi, Yasunobu Takaki   +7 more
doaj   +1 more source