Results 111 to 120 of about 157,061 (320)

Challenges of modeling pristane‐induced lupus in non‐human primates

Animal Models and Experimental Medicine, EarlyView.
Systemic lupus erythematosus (SLE) in cynomolgus monkeys was modeled by two intraperitoneal injections of pristane at a dose of 3.5 mL/kg, administered at weeks 1 and 23. Serum samples from all monkeys that received pristane tested positive for antinuclear antibodies.
Elena Vladimirovna Vinogradova, Maria Alexandrovna Varavko, Yakov Yuryevich Ustyugov, Alexey Alexandrovich Aleksandrov, Dmitry Alexandrovich Khochenkov, Yulia Nikolaevna Linkova   +5 more
wiley   +1 more source

Development and Characterization of Poly(Vinyl Alcohol)/Chitosan/Collagen Blends for the Treatment of Burn Wounds

Journal of Applied Polymer Science, EarlyView.
Schematic illustration of the poly(vinyl alcohol)/chitosan/collagen blend, highlighting the main physicochemical characterization results and the biological evaluations performed in an in vivo burn model. ABSTRACT Burns are complex injuries that require effective and multifunctional therapeutic approaches.
Bruna V. Quevedo, Luiz Ricardo Furlan Juvencio, Jessica Asami, Maria Lourdes Peris Barbo, Moema de Alencar Hausen, Daniel Komatsu, Eliana Aparecida de Rezende Duek   +6 more
wiley   +1 more source

Pilot findings on the real-world performance of xylazine test strips for drug residue testing and the importance of secondary testing methods

Drug and Alcohol Dependence Reports
Background: Xylazine is a sedative found increasingly in the illicit fentanyl supply that can cause hypotension, bradycardia, necrosis and death. This pilot examined the real-world performance of BTNX xylazine test strips (XTS) in drug residue samples ...
Erin Thompson, Jessica Tardif, Merci Ujeneza, Adina Badea, Traci C. Green, Haley McKee, Michelle McKenzie, Ju Nyeong Park   +7 more
doaj   +1 more source

Effects of ketamine/xylazine premedication on emulsified isoflurane general anaesthesia in swine undergoing embryo transplantation

Veterinární Medicína, 2014
Cardiorespiratory effects were assessed during ketamine/xylazine premedication followed by emulsified isoflurane anaesthesia in swine undergoing experimental embryo transplantation.
S. Jiang, K. Hu, H.G. Fan, B.S. Yin, X. Li, J.L. Hou, H.B. Wang   +6 more
doaj   +1 more source

Withdrawal Signs and Symptoms Among Patients Positive for Fentanyl With and Without Xylazine

Journal of addiction medicine
Background Xylazine is not approved for human use, yet it has emerged as a common adulterant of illicit fentanyl. It is currently unclear whether there is a withdrawal syndrome associated with xylazine and the potential impact of fentanyl coexposure ...
Ryan Alexander, Chinelo Agwuncha, Christopher Wilson, J. Schrecker, Andrew Holt, R. Heltsley   +5 more
semanticscholar   +1 more source

Effects of intermittent exposure to hypobaria and cold on the microarchitecture and morphofunctional profile of rat gastrocnemius muscle

The Anatomical Record, EarlyView.
Abstract Intermittent hypobaric hypoxia (IHH) enhances oxygen transport, muscle metabolism, and cardiovascular health; however, the combined effects of hypobaria and cold are less well understood. Exposure to these stressful environmental factors, even intermittently, can affect skeletal muscle due to its plasticity, thereby altering its metabolic and ...
Garoa Santocildes, Teresa Pagès, Ginés Viscor, Joan Ramon Torrella   +3 more
wiley   +1 more source

Opioid‐related xylazine toxicity manifesting as myonecrosis, rhabdomyolysis, multifocal ischemic cerebral infarcts, and cerebral edema

Journal of the American College of Emergency Physicians Open
This article provides a report of a case of organ dysfunction, myonecrosis, rhabdomyolysis, multifocal ischemic cerebral infarcts, and cerebral edema after a patient's use of xylazine and fentanyl. Within the US opioid epidemic, xylazine is emerging as a
Ogechi Nwodim, Ritesh Karsalia, Mark E. Heslin, Allyson E. Lieberman, Sally Zehui Wang, Atul A. Kalanuria, Holly C. Elser, Bernd Driessen, Christopher Caruso, George L. Anesi   +9 more
doaj   +1 more source

Intestinal Electric Stimulation Accelerates Whole Gut Transit and Promotes Fat Excrement in Conscious Rats [PDF]

, 2009
*_Introduction:_* Intestinal electric stimulation (IES) is proposed as a potential tool for the treatment of morbid obesity. Our previous study showed that IES with one pair of electrodes accelerated intestinal transit and decreased fat absorption in a ...
Jiande Chen, Ying Sun
core   +2 more sources

Dual Action of Dipyridamole in Experimental Rheumatoid Arthritis: Suppression of Joint Inflammation and Upregulation of Muscle Anabolism via Adenosine and AMPK pathways

Arthritis &Rheumatology, Accepted Article.
Introduction Rheumatoid sarcopenia, characterized by the progressive loss of skeletal muscle mass and function, is a frequent comorbidity in rheumatoid arthritis (RA), linked to prolonged, severe systemic inflammation. Purinergic signaling (adenosine, AMP, and ATP) plays a crucial role in inflammation, myogenesis, and muscle hypertrophy.
Miguel Marco‐Bonilla, Maria Fresnadillo, Irene Sanchez‐Platero, Macarena de la Riva‐Bueno, Fernando Huete‐Toral, Gonzalo Carracedo, Carmen Conde, Yolanda Benitez, Pablo Minguez, Sandra Carolina Cifuentes, Joaquin Rams, Gabriel Herrero‐Beaumont, Raquel Largo, Aránzazu Mediero   +13 more
wiley   +1 more source

Evaluation of the Therapeutic Potential of Bioactive Materials Based on a Complex of Oxidovanadium(IV) and Exopolysaccharide Levan in a Model of Insulin Resistance in Mice

ChemMedChem, EarlyView.
A low‐toxicity bioactive composition of oxidovanadium(IV) and exopolysaccharide levan is synthesized, characterized, and shown to reduce hyperglycemia, hypertriglyceridemia, and TyG index in a mice model of dexamethasone‐induced insulin resistance. Bioactive compositions containing vanadium complexes have been a viable strategy for constructing more ...
Amanda K. J. P. F. da Silva, Eucilene K. de L. B. Marques, Lidiane M. A. de Lima, Widarlane A. S. Alves, Dayane A. Gomes, Pedro L. Guzzo, Mônica F. Belian, Wagner E. Silva, Eduardo C. Lira   +8 more
wiley   +1 more source