Results 251 to 260 of about 157,061 (320)

Community-based drug checking at syringe service programs in New York City observe an increasing prevalence of xylazine from 2021 through 2024. [PDF]

Harm Reduct J
Gomez LAD, Estrada Y, Sauer J, Zaidi I, Trinidad AJ, Helmy H, Harocopos A.   +6 more
europepmc   +1 more source

Targeting necroptosis protects against astrocyte death and hippocampal sclerosis in experimental temporal lobe epilepsy

The Journal of Physiology, EarlyView.
Abstract figure legend Experimentally induced status epilepticus induces microglial TNFα release, which binds to astrocytic TNFR1 and triggers activation of RIPK1/RIPK3/MLKL signalling, initiating necroptotic astrocytic death that contributes to the development of hippocampal sclerosis. Created with Biorender.com.
Zhou Wu, Lukas Henning, Christian Steinhäuser, Peter Bedner   +3 more
wiley   +1 more source

Anesthesia is a potent determinant of ultra-high dose rate sparing in the murine total abdominal irradiation model. [PDF]

Front Oncol
Tavakkoli AD, Daley WW, Hunter DI, Allen BA, Carpenter GC, Gladstone DJ, Pogue BW, Hoopes PJ.   +7 more
europepmc   +1 more source

Sex‐specific differences in mortality and neurocardiac interactions in the Kv1.1 knockout mouse model of sudden unexpected death in epilepsy (SUDEP)

The Journal of Physiology, EarlyView.
Abstract figure legend The Kcna1 knockout mouse model of sudden unexpected death in epilepsy (SUDEP) exhibits sex‐specific differences in SUDEP risk. Female mice exhibit a lower SUDEP risk than males, despite similar seizure characteristics and interictal cardiac function across sexes.
Kelsey Paulhus, Praveen Kumar, Kelly Kneale, T. Noah Hutson, Nicole M. Gautier‐Hall, Deng‐Shan Shiau, Megan Watts, Krystle Trosclair, Hemangini A. Dhaibar, Paari Dominic, Leonidas Iasemidis, Edward Glasscock   +11 more
wiley   +1 more source

An integrated platform for 2‐D and 3‐D optical and electrical mapping of arrhythmias in Langendorff‐perfused rabbit hearts

The Journal of Physiology, EarlyView.
Abstract figure legend Integrated multimodal platform for panoramic cardiac mapping in isolated heart experiments. On the left, an image of the experimental setup during data acquisition showing a Langendorff‐perfused rabbit heart surrounded by three optical cameras (CAM A, B and C) positioned 120° apart, each coupled with high‐power LEDs for panoramic
Jimena Siles, Vinícius Silva, Tainan Neves, Italo Sandoval, Angélica Quadros, Giovanni Weber, Óscar Barquero, Ilija Uzelac, João Salinet   +8 more
wiley   +1 more source

Management of xylazine toxicity, overdose, dependence, and withdrawal: A systematic review. [PDF]

Am J Addict
Owusu-Antwi P, Atodaria P, Appiah-Kubi E, Shah Z, Garcia EM.   +4 more
europepmc   +1 more source

NAD replenishment restores mitochondrial function and thermogenesis in the brown adipose tissue of mice with obesity

The Journal of Physiology, EarlyView.
Abstract figure legend A high‐fat diet (HFD) induces brown adipose tissue (BAT) whitening, mitochondrial dysfunction (damaged cristae, fragmentation), reduced NAD+ levels and impaired thermogenesis, leading to lower energy expenditure and metabolic inflexibility.
Renata R. Braga, Matheus B. Rocha, Ana P. Morelli, Raul G. da Costa, Marcelo A. S. Mori, Adelino S. R. da Silva, José R. Pauli, Dennys E. Cintra, Eduardo R. Ropelle   +8 more
wiley   +1 more source

Chiral sensitivity of medetomidine lateral flow immunoassay test strips. [PDF]

Harm Reduct J
Amate A, Lieberman M.
europepmc   +1 more source

Exposures to synthetic cathinones, fentanyl, and xylazine among nightclub attendees in New York City, 2024. [PDF]

Drug Alcohol Depend
Palamar JJ, Abukahok N, Acosta P, Walton SE, Stang B, Krotulski AJ.   +5 more
europepmc   +1 more source