Evaluation of Atropine-Xylazine as a Sedative in Buffalo Calves (Bubalus bubalis)
Twelve experimental trials were undertaken on clinically healthy male buffalo calves. Atropine was administered @ 0.04 mg/kg, IM and xylazine was administered @ 0.04 mg/kg, IM.
S. Singh +4 more
doaj +1 more source
Xylazine-associated Wounds: Clinical Experience From a Low-barrier Wound Care Clinic in Philadelphia
The veterinary sedative xylazine is spreading in unregulated opioid supplies across North America. Among people who use drugs with repeated exposure to xylazine, a distinct wound type has emerged.
Rachel McFadden +6 more
semanticscholar +1 more source
Glutamate-mediated blood-brain barrier opening. implications for neuroprotection and drug delivery [PDF]
The blood-brain barrier is a highly selective anatomical and functional interface allowing a unique environment for neuro-glia networks. Blood-brain barrier dysfunction is common in most brain disorders and is associated with disease course and delayed ...
CECCANTI , MARCO +18 more
core +1 more source
Self-reported Xylazine Experiences: A Mixed Methods Study of Reddit Subscribers
Objectives: Xylazine is an alpha-2 agonist increasingly prevalent in the illicit drug supply. Our objectives were to curate information about xylazine through social media from People Who Use Drugs (PWUDs). Specifically, we sought to answer the following:
A. Spadaro +6 more
semanticscholar +2 more sources
Longitudinal Optogenetic Motor Mapping Revealed Structural and Functional Impairments and Enhanced Corticorubral Projection after Contusive Spinal Cord Injury in Mice [PDF]
Current evaluation of impairment and repair after spinal cord injury (SCI) is largely dependent on behavioral assessment and histological analysis of injured tissue and pathways. Here, we evaluated whether transcranial optogenetic mapping of motor cortex
Chai, Zhi +5 more
core +1 more source
Objectives Xylazine is a tranquilizer commonly added into the illicit drug supply and a likely contributor to overdoses because it does not respond to naloxone reversal. The objective of this study was to perform a retrospective data analysis on xylazine-
A. Holt +4 more
semanticscholar +1 more source
Reports from active drug users state that xylazine, the veterinary tranquilliser, has been increasing in the illicit drug supply in Philadelphia. To describe trends and characteristics of unintentional deaths from heroin and/or fentanyl overdose with ...
Jewell Johnson +3 more
semanticscholar +1 more source
Visualization of Endothelial Actin Cytoskeleton in the Mouse Retina [PDF]
Angiogenesis requires coordinated changes in cell shape of endothelial cells (ECs), orchestrated by the actin cytoskeleton. The mechanisms that regulate this rearrangement in vivo are poorly understood - largely because of the difficulty to visualize ...
Alessia Fraccaroli +10 more
core +5 more sources
Xylazine in Overdose Deaths and Forensic Drug Reports in US States, 2019-2022
Key Points Question To what extent is xylazine reported in fatal overdoses and law enforcement drug submissions in different states? Findings In this cross-sectional study of US overdose deaths and forensic reports, 16 states had no xylazine forensic ...
Manuel Cano +2 more
semanticscholar +1 more source
The New Stealth Drug on the Street: A Narrative Review of Xylazine as a Street Drug
Xylazine is an alpha-adrenergic receptor agonist approved for use only in animals with a prescription from a veterinarian. It is a powerful sedative that is slowly infiltrating the recreational street drug scene and is often used by polysubstance abusers.
Joseph V. Pergolizzi Jr. +5 more
semanticscholar +1 more source

