Results 71 to 80 of about 157,061 (320)

Developmental sensory experience balances cortical excitation and inhibition. [PDF]

, 2010
Early in life, neural circuits are highly susceptible to outside influences. The organization of the primary auditory cortex (A1) in particular is governed by acoustic experience during the critical period, an epoch near the beginning of postnatal ...
Barker, Alison J, Dorrn, Anja L, Froemke, Robert C, Schreiner, Christoph E, Yuan, Kexin   +4 more
core   +3 more sources

Directional Liquid Transport Enabled pH‐Responsive Hierarchical Composite for Enhanced Wound Healing

Advanced Healthcare Materials, EarlyView.
A hierarchical composite with a gradient architecture transitioning from hydrophobic to hydrophilic layers integrates diode‐like liquid transport, efficient water absorption, breathability, and mechanical robustness. This device enables a multifunctional therapeutic platform with pH‐responsive dual‐drug release, providing synergistic anti‐inflammatory ...
Baolin Wang, Li‐Fang Zhu, Yuna Lang, Siyi Zhang, Fei Chen, Ming‐Wei Chang   +5 more
wiley   +1 more source

Annexin A13 Protects Against Acute Kidney Injury by Inactivating TGF‐β/Smad3 Signaling

Advanced Science, EarlyView.
ANXA13 is negatively regulated by Smad3 and exerts its protective role in AKI by inactivating TGF‐β/Smad3 signaling and Smad3‐p21 cell cycle arrest pathway through binding to TβRI, inhibiting the interaction between TβRI and TβRII, thereby suppressing TβRI phosporylation.
Jiaxiao Li, Chen Wu, Yuqi Zhu, Zicheng Liu, Wenjuan Yu, Andrew Lukwaro, Yu Zhong, Guoqiang Xie, Lili Zhou, Xiaoru Huang, Hui‐yao Lan, Junzhe Chen, Ying Tang   +12 more
wiley   +1 more source

Xylazine awareness, desire, use and exposure: Preliminary findings from the Rhode Island community-based drug checking cohort study

Drug and Alcohol Dependence Reports
Background: Xylazine is an ⍺2 adrenergic receptor agonist and a veterinary sedative that can cause severe health complications yet interventions to detect and treat human exposure remain underdeveloped.
Ju Nyeong Park, Rachel Serafinski, Merci Ujeneza, Michelle McKenzie, Jessica Tardif, Alex J. Krotulski, Adina Badea, Elyse R. Grossman, Traci C. Green   +8 more
doaj   +1 more source

Type II spiral ganglion afferent neurons drive medial olivocochlear reflex suppression of the cochlear amplifier. [PDF]

, 2015
The dynamic adjustment of hearing sensitivity and frequency selectivity is mediated by the medial olivocochlear efferent reflex, which suppresses the gain of the 'cochlear amplifier' in each ear.
Cederholm, Jennie ME, Froud, Kristina E, Housley, Gary D, Julien, Jean-Pierre, Klugmann, Matthias, Ryan, Allen F, Sandow, Shaun L, Wong, Ann Chi Yan   +7 more
core   +2 more sources

Modifying Glucose Metabolism Reverses Memory Defects of Alzheimer's Disease Model at Late Stages

Advanced Science, EarlyView.
Using spatial transcriptomics, we show that ferul enanthate (SL‐ZF‐01) reverses episodic‐like memory deficits in aged, but not young, Alzheimer’s disease (AD) mice. SL restores glucose metabolism and Glucose Transporter 1/3 expression via an ‘Aging‐AD‐Rescue’ pattern, rescuing deficits seen in aged AD mice.
Fang Liu, Yiyu‐Li Tang, Zong‐Bo Zhang, Ya‐Hong Tan, Si‐Hui Lin, Ni‐Ya Wang, Jin‐Nan Li, Zhi‐Jie Pan, Jian‐Feng Li, Jing‐Fei Huang, Yu‐Qiang Ding, Chun‐Ming Guo, Lin Xu, Cheng Peng, Qi‐Xin Zhou   +14 more
wiley   +1 more source

Neurobehavioral Impacts of Xylazine and Piracetam Interaction on NADH Oxidase in the Rat Brain

Kufa Journal for Veterinary Medical Sciences
      In the present study, the effects of different doses of xylazine combined with piracetam were investigated through different behavioral experiments. Xylazine is alpha 2 adrenergic agonist a veterinary sedative, and analgesic agent.
Shaker M. Kermasha, Mohammad T. Naqi Al-Bayati   +1 more
doaj   +1 more source

The safety profile of the anesthetic effect of alfaxalone and its interaction with xylazine and ketamine in chick’s model (Gallus gallus domesticus)

Macedonian Veterinary Review, 2021
The objective of our research was to estimate the therapeutic index and assess the interaction of alfaxalone (IP) with ketamine or xylazine (IM) in chicks by using isobolographic analysis.
Amjed Najem Alatrushi, Ahmed Salah Naser
doaj   +1 more source

Accurate molecular imaging of small animals taking into account animal models, handling, anaesthesia, quality control and imaging system performance [PDF]

, 2015
Small-animal imaging has become an important technique for the development of new radiotracers, drugs and therapies. Many laboratories have now a combination of different small-animal imaging systems, which are being used by biologists, pharmacists ...
Bankstahl, Jens, Belcari, Nicola, Krämer, Stefanie, Vandenberghe, Stefaan, Vanhove, Christian, Visser, Eric   +5 more
core   +1 more source

Nanoscale Mapping of the Subcellular Glycosylation Landscape

Advanced Science, EarlyView.
Using multiplexed super‐resolution imaging with fluorophore‐labeled lectins, this study reports intracellular glycosylation at the nanoscale across organelles and synaptic specializations. Extending glycan analysis beyond the cell surface, Glyco‐STORM reveals distinct glycosylation nanodomains in the ER, Golgi, lysosomes, and synaptic sites.
Helene Gregoria Schroeter, Steffen Sass, Mike Heilemann, Thomas Kuner, Maja Klevanski   +4 more
wiley   +1 more source