Метаболическая инженерия дрожжей Hansenula polymorpha для создания эффективных продуцентов этанола [PDF]
До недавнего времени никто не рассматривал метилотрофные дрожжи как потенциальный продуцент биотоплива, в частности биоэтанола, из гидролизатов лигноцеллюлозы.
Дмитрук, К.В. +1 more
core +1 more source
Balancing Cell Growth and Product Synthesis for Efficient Microbial Cell Factories
This review presents state‐of‐the‐art metabolic engineering strategies to balance microbial cell growth and product synthesis in biorefineries. It surveys pathway engineering, dynamic genetic circuits, orthogonal control systems, synthetic microbial consortia, and fermentation optimization, alongside integrative modeling approaches.
Linxia Liu +5 more
wiley +1 more source
Elucidation of the recognition mechanisms for hemicellulose and pectin in Clostridium cellulovorans using intracellular quantitative proteome analysis [PDF]
Clostridium cellulovorans is an anaerobic, cellulolytic bacterium, capable of effectively degrading and metabolizing various types of substrates, including cellulose, hemicellulose (xylan and galactomannan), and pectin.
Hironobu Morisaka +4 more
core +2 more sources
This review explores the role of microbial and plant enzymes in food processing, highlighting advancements in molecular engineering and sustainable production from underutilized agro‐industrial waste. It focuses on key enzymes such as amylase, lipase, protease, and lactase, discussing their applications, advantages, and challenges in enhancing product ...
Fahima Siddikey +8 more
wiley +1 more source
Regulation of D-galacturonate metabolism in Caulobacter crescentus by HumR, a LacI-family transcriptional repressor [PDF]
The oligotrophic freshwater bacterium Caulobacter crescentus encodes a cluster of genes (CC_1487 to CC_1495) shown here to be necessary for metabolism of D-galacturonate, the primary constituent of pectin, a major plant polymer.
Caswell, Deborah +10 more
core +1 more source
Comprehensive multi‐omics analysis revealed that volatile metabolite stigmasterol plays a crucial role in the defence against root rot in Panax notoginseng, and its accumulation level is positively modulated by PnWRKY4. ABSTRACT Root rot disease in Panax notoginseng, primarily caused by the pathogenic fungus Fusarium solani, significantly impacts the ...
Xiao‐min Li +5 more
wiley +1 more source
Sn-Beta zeolites with borate salts catalyse the epimerization of carbohydrates via an intramolecular carbon shift [PDF]
Carbohydrate epimerization is an essential technology for the widespread production of rare sugars. In contrast to other enzymes, most epimerases are only active on sugars substituted with phosphate or nucleotide groups, thus drastically restricting ...
A Corma +45 more
core +1 more source
The authors identify PbfF (previously annotated as a NAD‐dependent dehydrogenase) as a hitherto unknown enzyme in phosphonate catabolism. Guided by genome context analysis, they show that PbfF is actually a racemase, serving to degrade the natural compound (S)‐2‐amino‐1‐hydroxyethylphosphonate (S‐HAEP).
Francesca Ruffolo +8 more
wiley +1 more source
Synthetically-primed adaptation of Pseudomonas putida to a non-native substrate D-xylose
To broaden the substrate scope of microbial cell factories towards renewable substrates, rational genetic interventions are often combined with adaptive laboratory evolution (ALE).
Pavel Dvořák +11 more
doaj +1 more source
Structure of 3,4-Dihydroxy-2-butanone 4-Phosphate Synthase from Methanococcus jannaschii in Complex with Divalent Metal Ions and the Substrate Ribulose 5-Phosphate: implications for the catalytic mechanism [PDF]
Skeletal rearrangements of carbohydrates are crucial for many biosynthetic pathways. In riboflavin biosynthesis ribulose 5-phosphate is converted into 3,4-dihydroxy-2-butanone 4-phosphate while its C4 atom is released as formate in a sequence of metal ...
Bacher, Adelbert +5 more
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