Results 1 to 10 of about 36,484 (234)
Cancer Communications, 2023 Background Nuclear Yes1‐associated transcriptional regulator (YAP1) promotes tumor progression. However, the function of cytoplasmic YAP1 in breast cancer cells and its impact on the survival of breast cancer patients remain unclear.
Yan Guo +11 more
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Increased expression of YAP1 in prostate cancer correlates with extraprostatic extension [PDF]
Cancer Biology & Medicine, 2017 Objective: Yes associated protein 1 (YAP1) is a member of the Hippo pathway, acting as a transcriptional coactivator. To elucidate the role of YAP1 and phosphorylated (p)YAP1 in prostate cancer (PCa) tumorigenesis, we investigated their expression in ...
Filiz Kisaayak Collak +4 more
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The Journal of Clinical InvestigationThe Hippo signaling pathway plays a key role in tumorigenesis in different cancer types. We investigated the role of the Hippo effector YAP1 in the tumor immune microenvironment (TIME) of urothelial carcinoma of the bladder (UCB) and evaluated the ...
Pritam Sadhukhan +12 more
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Transcriptional control of PPP2CB by YAP1 and TEAD1 mediates AMPK inhibition and mTORC1 activation in vascular smooth muscle cells [PDF]
iScienceSummary: We previously demonstrated that the transcriptional co-factor Yes-associated protein 1 (YAP1) promotes vascular smooth muscle cell (VSMC) phenotypic switching and neointima formation. However, the underlying mechanisms remain unclear.
Sanjana Kumariya +3 more
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Experimental and Molecular MedicineThe senescence of alveolar type II (AT2) cells impedes self-repair of the lung epithelium and contributes to lung injury in the setting of idiopathic pulmonary fibrosis (IPF).
Wei Su +20 more
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YAP1 inhibition protects retinal vascular endothelial cells under high glucose by inhibiting autophagy [PDF]
Open Life SciencesDiabetic retinopathy (DR) is a frequent diabetes‐associated microvascular disorder, and its underlying mechanism of pathogenesis remains unclear. Previous studies have suggested that YAP1 is involved in endothelial activation and vascular inflammation ...
Li Yu-Shan +4 more
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Molecular Subtypes of High-Grade Neuroendocrine Carcinoma (HGNEC): What is YAP1-Positive HGNEC?
Frontiers in Bioscience-Landmark, 2022 Small cell lung cancer (SCLC) subtype classification, based on high-level expression of key transcriptional regulators; ASCL1 (SCLC-A), NEUROD1 (SCLC-N), POU2F3 (SCLC-P), and YAP1 (SCLC-Y), has recently been proposed.
Hitomi Kawai +3 more
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Cell Reports, 2023 Summary: YAP1 functions in lineage differentiation of pluripotent embryonic stem cells (ESCs); however, the detailed mechanisms underlying the regulation of YAP1 activity during ESC differentiation remain elusive.
Ruipeng Zhuge +5 more
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CircSETD2 inhibits YAP1 by interaction with HuR during breast cancer progression
Cancer Biology & Therapy, 2023 CircRNAs have been proven to play a pivotal role in cancer progression. The present study aims to explore the roles and related mechanisms of circSETD2 in breast cancer proliferation, migration and invasion. The expression of circSETD2 in BC was assessed
Lan Jing +4 more
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Yap1-2 Isoform Is the Primary Mediator in TGF-β1 Induced EMT in Pancreatic Cancer
Frontiers in Oncology, 2021 Pancreatic ductal adenocarcinoma (PDAC) is the most aggressive human malignancy and intrinsically resistant to conventional therapies. YAP1, as a key downstream effector of the Hippo pathway, plays an important role in tumorigenesis including PDAC ...
Chao Gao +14 more
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