Results 11 to 20 of about 36,484 (234)
YAP1 Exerts Its Transcriptional Control via TEAD-Mediated Activation of Enhancers. [PDF]
PLoS Genetics, 2015 YAP1 is a major effector of the Hippo pathway and a well-established oncogene. Elevated YAP1 activity due to mutations in Hippo pathway components or YAP1 amplification is observed in several types of human cancers.
Claudia Stein +10 more
doaj +1 more source
Advancement of science, 2023 The interplay between immune cells/macrophages and fibroblast‐like synoviocytes (FLSs) plays a pivotal role in initiating synovitis; however, their involvement in metabolic disorders, including diabetic osteoarthritis (DOA), is largely unknown.
Jie Yang +18 more
semanticscholar +1 more source
LINC02159 promotes non-small cell lung cancer progression via ALYREF/YAP1 signaling
Molecular Cancer, 2023 Lung cancer is the leading cause of cancer-related deaths worldwide. Long non-coding RNAs (lncRNAs) have emerged as key regulators of cancer development and progression, and as promising biomarkers for the diagnosis and prognosis of cancer. In this study,
Qiurong Yang +9 more
semanticscholar +1 more source
YAP1 promotes multidrug resistance of small cell lung cancer by CD74‐related signaling pathways
Cancer Medicine, 2020 Background Our previous research found that YAP1 may have a role in multidrug resistance (MDR) in small cell lung cancer (SCLC). However, its underlying mechanism is unknown.
Yongchun Song +4 more
doaj +1 more source
Cells, 2020 Background: Tumor-associated macrophages (TAMs) constitute a major portion of the leukocyte infiltrate found in breast cancer (BC). BC cells may reprogram TAMs in a pro-angiogenic and immunosuppressive sense.
Sara Donzelli +8 more
doaj +1 more source
YAP1 alleviates sepsis-induced acute lung injury via inhibiting ferritinophagy-mediated ferroptosis
Frontiers in Immunology, 2022 Ferroptosis is a phospholipid peroxidation-mediated and iron-dependent cell death form, involved in sepsis-induced organ injury and other lung diseases.
Jing Zhang +6 more
semanticscholar +1 more source
Multiomic characterization of small cell lung cancer: Real-world insights into therapeutic opportunities. [PDF]
CancerNK, natural killer; STING, Stimulator of Interferon Genes; TCI, T‐cell inflamed. Abstract Background The dominant expression of lineage‐related transcription factors (TFs)—ASCL1, NEUROD1, POU2F3, and, controversially, YAP1—has enabled the classification of small cell lung cancer (SCLC) into distinct subtypes (SCLC‐A/N/P/Y, respectively).
Puri S +18 more
europepmc +2 more sources
Cell Death and Disease, 2021 Chondrosarcoma (CHS) is the second most common bone malignancy with limited therapeutic approaches. Our previous study has found that Yes associated protein 1 (YAP1) is downregulated in CHS cells treated with bromodomain and extraterminal domain (BET ...
Huan-Tian Zhang +15 more
doaj +1 more source
Post-translational deregulation of YAP1 is genetically controlled in rat liver cancer and determines the fate and stem-like behavior of the human disease [PDF]
, 2016 Previous studies showed that YAP1 is over-expressed in hepatocellular carcinoma (HCC). Here we observed higher expression of Yap1/Ctgf axis in dysplastic nodules and HCC chemically-induced in F344 rats, genetically susceptible to hepatocarcinogenesis ...
Avila, Matias A. +13 more
core +2 more sources
Neoplasia: An International Journal for Oncology Research, 2021 Increased expression of Yes-associated protein-1 (YAP1) was shown to correlate with reduced survival in breast cancer (BC) patients. However, the exact mechanism of YAP1 regulation in BC cells remains ambiguous.
Jibran Sualeh Muhammad +9 more
doaj +1 more source