Results 31 to 40 of about 36,484 (234)

WNT5a Signaling through ROR2 Activates the Hippo Pathway to Suppress YAP1 Activity and Tumor Growth.

Cancer Research, 2023
Noncanonical Wnt signaling by WNT5a has oncogenic and tumor suppressive activities, but downstream pathways mediating these specific effects remain to be fully established.
Keshan Wang, Fen Ma, S. Arai, Yun Wang, Andreas Varkaris, L. Poluben, O. Voznesensky, Fang Xie, Xiaoping Zhang, Xin Yuan, S. Balk   +10 more
semanticscholar   +1 more source

Pan-urologic cancer genomic subtypes that transcend tissue of origin [PDF]

, 2017
Urologic cancers include cancers of the bladder, kidney, prostate, and testes, with common molecular features spanning different types. Here, we show that 1954 urologic cancers can be classified into nine major genomic subtypes, on the basis of ...
Bossé, Dominick, Chen, Fengju, Choueiri, Toni K, Creighton, Chad J, Gibbons, Don L, Hakimi, A. Ari, Hsieh, James J, Ittmann, Michael, Lalani, Aly-Khan A, Zhang, Yiqun   +9 more
core   +2 more sources

YAP1 synergize with YY1 transcriptional co-repress DUSP1 to induce osimertinib resistant by activating the EGFR/MAPK pathway and abrogating autophagy in non-small cell lung cancer

International Journal on Biological Sciences, 2023
YAP1 is a well-known core effector of the Hippo pathway in tumors, but its potential role in osimertinib resistance remained unexplored. Our study provides evidence that YAP1 acts as a potent promoter of osimertinib resistance.
Yue Ning, Hongmei Zheng, Yang Yang, H. Zang, Weiyuan Wang, Yuting Zhan, Haihua Wang, Jiadi Luo, Q. Wen, Jinwu Peng, Juanjuan Xiang, S. Fan   +11 more
semanticscholar   +1 more source

APE1 redox function is required for activation of Yes-associated protein 1 under reflux conditions in Barrett’s-associated esophageal adenocarcinomas

Journal of Experimental & Clinical Cancer Research, 2022
Background Esophageal adenocarcinoma (EAC) is characterized by poor prognosis and low survival rate. Chronic gastroesophageal reflux disease (GERD) is the main risk factor for the development of Barrett’s esophagus (BE), a preneoplastic metaplastic ...
Farah Ballout, Heng Lu, Lei Chen, Kannappan Sriramajayam, Jianwen Que, Zhipeng Meng, Timothy C. Wang, Silvia Giordano, Alexander Zaika, Oliver McDonald, Dunfa Peng, Wael El-Rifai   +11 more
doaj   +1 more source

New Insights into the Roles of Yes-Associated Protein (YAP1) in Colorectal Cancer Development and Progression [PDF]

Iranian Journal of Colorectal Research, 2019
Yes-associated protein (YAP1), the downstream effector of the Hippo pathway, plays important roles in the regulation of tissue reconstruction,stem cell proliferation, and development of different cancers.
Fariba Dehghanian, Zahra Azhir, Atefeh Akbari, Zohreh Hojati   +3 more
doaj  

Capicua suppresses YAP1 to limit tumorigenesis and maintain drug sensitivity in human cancer

Cell Reports, 2022
Summary: Inactivation of Capicua (CIC) or upregulation of yes-associated protein 1, YAP1, leads to broad RAS-RAF-MEK-ERK inhibitor resistance and tumor progression in multiple human cancers.
Ji Won Kim, Cuyler Luck, Wei Wu, Rovingaile Kriska Ponce, Yone Kawe Lin, Nehal Gupta, Ross A. Okimoto   +6 more
doaj   +1 more source

Tyrosine kinase SRC-induced YAP1-KLF5 module regulates cancer stemness and metastasis in triple-negative breast cancer

Cellular and Molecular Life Sciences, 2023
SRC is the first identified oncogene, and its aberrant activation has been implicated as a driving event in tumor initiation and progression. However, its role in cancer stemness regulation and the underlying regulatory mechanism are still elusive. Here,
Hailin Zou, Juan Luo, Yibo Guo, Tongyu Tong, Yuchen Liu, Yun Chen, Yunjun Xiao, L. Ye, Cheng-long Zhu, L. Deng, Bo Wang, Yihang Pan, Peng Li   +12 more
semanticscholar   +1 more source

Regulation of Cardiomyocyte Proliferation by microRNAs and Small Molecules [PDF]

, 2018
Understanding the molecular mechanisms regulating cardiac cell proliferation during the embryonic, fetal and adult life holds a paramount importance in view of developing innovative strategies aimed at inducing myocardial regeneration after cardiac ...
Torrini, Consuelo
core   +1 more source

Circular RNA_0000326 accelerates breast cancer development via modulation of the miR-9-3p/YAP1 axis.

Neoplasma (Bratislava), 2023
Circular RNA (circ)_0000326 has been reported in bladder cancer and cervical cancer and is concerned to be involved with the development of cancerous cells.
Xiaohui Xue, Shuai Zhao, Mengqi Xu, Ying Li, Wenfei Liu, H. Qin   +5 more
semanticscholar   +1 more source

miR-375 Inhibits Proliferation of Mouse Pancreatic Progenitor Cells by Targeting YAP1

Cellular Physiology and Biochemistry, 2013
Background/Aims: The Hippo signaling pathway regulates expansion and differentiation of stem cells and tissue progenitor cells during organ development and tissue regeneration.
Zhen-Wu Zhang, Tong Men, Rui-Cheng Feng, Yun-Chao Li, Di Zhou, Chun-Bo Teng   +5 more
doaj   +1 more source