Results 41 to 50 of about 36,484 (234)

Mitoguardin 1 and 2 promote granulosa cell proliferation by activating AKT and regulating the Hippo-YAP1 signaling pathway

Cell Death and Disease, 2023
Mitochondria have been identified to be involved in oxidative phosphorylation, lipid metabolism, cell death, and cell proliferation. Previous studies have demonstrated that mitoguardin (Miga), a mitochondrial protein that governs mitochondrial fusion ...
Ming-Qi Yan, Bing Zhu, Xiao-hong Liu, Yu-Meng Yang, Xiu-Yun Duan, Yong Wang, Hui Sun, Mei Feng, Tao Li, Xiao-Man Liu   +9 more
semanticscholar   +1 more source

Ybp1 and Gpx3 signaling in Candida albicans govern hydrogen peroxide-induced oxidation of the Cap1 transcription factor and macrophage escape [PDF]

, 2013
Peer reviewedPublisher ...
Alarco AM, Alessandra da Silva Dantas, Brian A. Morgan, Christopher G. McKenzie, Deborah A. Smith, Donna M. MacCallum, Elizabeth A. Veal, Janet Quinn, Lars-Peter Erwig, Miranda J. Patterson, Sam Sherston, Vazquez-Torres A, Wysong DR   +12 more
core   +1 more source

YAP1 Recognizes Inflammatory and Mechanical Cues to Exacerbate Benign Prostatic Hyperplasia via Promoting Cell Survival and Fibrosis

Advancement of science, 2023
Chronic prostatic inflammation promotes cell survival and fibrosis, leading to benign prostatic hyperplasia (BPH) with aggravated urinary symptoms.
Dongxu Lin, Changcheng Luo, Pengyu Wei, An Zhang, Mengyang Zhang, Xiaoliang Wu, Bolang Deng, Zhipeng Li, Kai Cui, Zhong Chen   +9 more
semanticscholar   +1 more source

YAP1 Inhibition Induces Phenotype Switching of Cancer-Associated Fibroblasts to Tumor Suppressive in Prostate Cancer

Cancer Research
YAP1 regulates cancer-associated fibroblast phenotypes and can be targeted to switch cancer-associated fibroblasts from a protumorigenic subtype that promotes extracellular matrix deposition to a tumor-suppressive subtype that stimulates antitumor ...
Hongtao Song, Tong Lu, Donghui Han, Jiayu Zhang, L. Gan, Chao Xu, Shaojie Liu, Peng Li, Keying Zhang, Zhihao Hu, Hongji Li, Yu Li, Xiaolong Zhao, Jingliang Zhang, Nianzeng Xing, Changhong Shi, Weihong Wen, Fa Yang, Weijun Qin   +18 more
semanticscholar   +1 more source

YAP1 protects against PM2.5-induced lung toxicity by suppressing pyroptosis and ferroptosis.

Ecotoxicology and Environmental Safety, 2023
Pollution from fine particulate matter (PM2.5) has become a major threat to public health and has been related to lung toxicity. One of the key regulators of the Hippo signaling system, Yes-associated protein 1 (YAP1), is speculated to play a role in ...
Yun Wang, Haifeng Duan, Jing Zhang, Qingyuan Wang, Tuohua Peng, Xujun Ye, Zhenshun Cheng, Xinyi Li   +7 more
semanticscholar   +1 more source

Increasing β-catenin/Wnt3A activity levels drive mechanical strain-induced cell cycle progression through mitosis. [PDF]

, 2016
Mechanical force and Wnt signaling activate β-catenin-mediated transcription to promote proliferation and tissue expansion. However, it is unknown whether mechanical force and Wnt signaling act independently or synergize to activate β-catenin signaling ...
Benham-Pyle, Blair W, Hart, Kevin C, Nelson, William James, Pruitt, Beth L, Sim, Joo Yong   +4 more
core   +2 more sources

Residual ANTXR1+ myofibroblasts after chemotherapy inhibit anti-tumor immunity via YAP1 signaling pathway

Nature Communications
Although cancer-associated fibroblast (CAF) heterogeneity is well-established, the impact of chemotherapy on CAF populations remains poorly understood.
Monika Licaj, R. Mhaidly, Y. Kieffer, H. Croizer, C. Bonneau, A. Meng, L. Djerroudi, Kevin Mujangi-Ebeka, H. Hocine, B. Bourachot, Ilaria Magagna, Renaud Leclère, Léa Guyonnet, Mylène Bohec, Coralie L. Guerin, S. Baulande, M. Kamal, C. Le tourneau, Fabrice Lécuru, Véronique Becette, Roman Rouzier, A. Vincent‐Salomon, Géraldine Gentric, F. Mechta‐Grigoriou   +23 more
semanticscholar   +1 more source

YAP1 expression is associated with survival and immunosuppression in small cell lung cancer

Cell Death and Disease, 2023
Immunotherapy is considered a major breakthrough in the treatment of small cell lung cancer (SCLC), although its anti-tumor efficacy is limited. With a high degree of malignancy and high heterogeneity, SCLC is difficult to treat in the clinic.
Peixin Chen, Chenglong Sun, Hao Wang, Wencheng Zhao, Yanlin Wu, Haoyue Guo, Caicun Zhou, Yayi He   +7 more
semanticscholar   +1 more source

GPER-induced signaling is essential for the survival of breast cancer stem cells. [PDF]

, 2020
G protein-coupled estrogen receptor-1 (GPER), a member of the G protein-coupled receptor (GPCR) superfamily, mediates estrogen-induced proliferation of normal and malignant breast epithelial cells.
Chan, Yu-Tzu, Chang, Wen-Wei, Chang, Wen-Ying, Chen, Yu-Ju, Lai, Alan C-Y, Lin, Ruey-Jen, Lin, Yu-Ju, Wang, Ya-Hui, Wang, Yi-Ting, Wu, Hsin-Yi, Wu, Jen-Chine, Yu, Alice L, Yu, Jyh-Cherng   +12 more
core   +2 more sources

CSN6‐SPOP‐HMGCS1 Axis Promotes Hepatocellular Carcinoma Progression via YAP1 Activation

Advancement of science
Cholesterol metabolism has important roles in maintaining membrane integrity and countering the development of diseases such as obesity and cancers. Cancer cells sustain cholesterol biogenesis for their proliferation and microenvironment reprograming ...
Kai Li, Jiayu Zhang, Haiwen Lyu, Jinneng Yang, Wenxia Wei, Yuzhi Wang, Haidan Luo, Yijing Zhang, Xin Jiang, Hairong Yi, Mengan Wang, Caiyun Zhang, Kang Wu, Lishi Xiao, Weijie Wen, Hui Xu, Guolin Li, Yunle Wan, Fang Yang, Runxiang Yang, Xinhui Fu, Baifu Qin, Zhongguo Zhou, Haipeng Zhang, Mong-Hong Lee   +24 more
semanticscholar   +1 more source