Results 51 to 60 of about 36,484 (234)

The transcriptional co‐activator Yap1 promotes adult hippocampal neural stem cell activation

EMBO Journal, 2023
Most adult hippocampal neural stem cells (NSCs) remain quiescent, with only a minor portion undergoing active proliferation and neurogenesis. The molecular mechanisms that trigger the transition from quiescence to activation are still poorly understood ...
Wenqiang Fan, Jerónimo Jurado-Arjona, Gregorio Alanis-Lobato, Sophie Péron, C. Berger, Miguel Andrade, S. Falk, B. Berninger   +7 more
semanticscholar   +1 more source

Genome-wide CRISPR screening reveals novel therapeutic targets in RIT1-driven lung cancer

Molecular & Cellular Oncology, 2021
In recent work, we performed CRISPR/Cas9 screening in RIT1 (Ras-like in all tissues)-mutant cancer cells. We found that RIT1-mutant cells are vulnerable to loss of mitotic regulators, and mutant RIT1 synergizes with YAP1 (yes-associated protein 1) in ...
Amanda K. Riley, Alice H. Berger
doaj   +1 more source

Resistance-promoting effects of ependymoma treatment revealed through genomic analysis of multiple recurrences in a single patient [PDF]

, 2018
As in other brain tumors, multiple recurrences after complete resection and irradiation of supratentorial ependymoma are common and frequently result in patient death.
Dahiya, Sonika, Dunn, Gavin P, Fulton, Robert S, Li, Tiandao, Mardis, Elaine R, Miller, Christopher A, Rubin, Joshua B, Smyth, Matthew D   +7 more
core   +3 more sources

n-3 PUFA Promotes Ferroptosis in PCOS GCs by Inhibiting YAP1 through Activation of the Hippo Pathway

Nutrients, 2023
Polycystic ovary syndrome (PCOS) is an endocrine disorder characterized by hyperandrogenemia with multiple suspended sinus follicles, thickened cortical tissue, and excessive proliferation of ovarian granulosa cells that severely affects the fertility ...
Peiwen Zhang, Yuheng Pan, Shuang Wu, Yuxu He, Jinyong Wang, Lei Chen, Shunhua Zhang, Hui Zhang, Ye Zhao, L. Niu, M. Gan, Yan Wang, Linyuan Shen, Li Zhu   +13 more
semanticscholar   +1 more source

RESCUE OF HIPPO CO-ACTIVATOR YAP1 TRIGGERS DNA DAMAGE-INDUCED APOPTOSIS IN HEMATOLOGICAL CANCERS [PDF]

, 2014
Oncogene–induced DNA damage elicits genomic instability in epithelial cancer cells, but apoptosis is blocked through inactivation of the tumor suppressor p53. In hematological cancers, the relevance of ongoing DNA damage and mechanisms by which apoptosis
Alec C Kimmelman, Antonino Neri, BA Walker, BL Bennett, Chunxiao Xu, CL Creasy, CM Annunziata, D Levy, D Levy, D Pan, D Zhou, D Zhou, DK Walters, DR Carrasco, E Bertini, E Lapi, E White, Elena Antonini, Elisa ten Hacken, Federico Caligaris-Cappio, Francesca Cottini, Giovanni Blandino, Giovanni Tonon, I Hickson, J Bartkova, JJ Keats, K Tschop, K Yoshida, Kenneth C Anderson, KF Harvey, Kwok-Kin Wong, L Brown, Luca Agnelli, M Sudol, MA Chapman, Magda Marcatti, Maria Teresa Bertilaccio, Martin Sattler, Martina Dori, Maurilio Ponzoni, N Reuven, Paul G Richardson, R Baskaran, Ruben Carrasco, S Basu, S Boehrer, S Kharbanda, S Piccolo, S Strano, S Strano, T Shafman, TD Halazonetis, Teru Hideshima, VG Gorgoulis, W Michael Kuehl, WG Kaelin Jr., ZM Yuan, ZM Yuan, ZY Xu-Monette   +58 more
core   +2 more sources

Inhibition of YAP1 activity ameliorates acute lung injury through promotion of M2 macrophage polarization

MedComm, 2023
The balance of M1/M2 macrophage polarization plays an important role in regulating inflammation during acute lung injury (ALI). Yes‐associated protein (YAP1) is a key protein in the Hippo–YAP1 signaling pathway and is involved in macrophage polarization.
Lu Liang, Wen Xu, Ao Shen, Xiaomei Fu, Huiyu Cen, Siran Wang, Zhongxiao Lin, Lingmin Zhang, Fangyu Lin, Xin Zhang, Na Zhou, Jishuo Chang, Zhe‐Sheng Chen, Chu-Wen Li, Xi-yong Yu   +14 more
semanticscholar   +1 more source

14-3-3σ regulation of and interaction with YAP1 in acquired gemcitabine resistance via promoting ribonucleotide reductase expression [PDF]

, 2016
Gemcitabine is an important anticancer therapeutics approved for treatment of several human cancers including locally advanced or metastatic pancreatic ductal adenocarcinoma (PDAC).
Dong, Zizheng, Qin, Li, Zhang, Jian-Ting
core   +1 more source

Targeting the Hippo/YAP1 signaling pathway in hepatocellular carcinoma: From mechanisms to therapeutic drugs (Review)

International Journal of Oncology
The Hippo signaling pathway plays a pivotal role in regulating cell growth and organ size. Its regulatory effects on hepatocellular carcinoma (HCC) encompass diverse aspects, including cell proliferation, invasion and metastasis, tumor drug resistance ...
Shenghao Li, L. Hao, Na Li, Xiaoyu Hu, Huimin Yan, Erhei Dai, Xinli Shi   +6 more
semanticscholar   +1 more source

Distinct regulations driving YAP1 expression loss in poroma, porocarcinoma and RB1‐deficient skin carcinoma

Histopathology, 2023
Recently, YAP1 fusion genes have been demonstrated in eccrine poroma and porocarcinoma, and the diagnostic use of YAP1 immunohistochemistry has been highlighted in this setting.
T. Kervarrec, E. Frouin, C. Collin, A. Tallet, Matthias Tallegas, D. Pissaloux, F. Tirode, S. Guyétant, M. Samimi, P. Gaboriaud, A. Touzé, D. Schrama, R. Houben, Flore Tabareau-Delalande, A. Neuhart, A. de la Fouchardière, A. Osio, B. Cavelier-Balloy, S. Laurent-Roussel, P. Sohier, Tilmant Cyprien, B. Balme, Fanny Belzung, M. Jullie, B. Cribier, M. Battistella, N. Macagno   +26 more
semanticscholar   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source