Results 61 to 70 of about 36,484 (234)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Redox modulation of plant developmental regulators from the class I TCP transcription factor family [PDF]

, 2013
TEOSINTE BRANCHED1-CYCLOIDEA-PROLIFERATING CELL FACTOR1 (TCP) transcription factors participate in plant developmental processes associated with cell proliferation and growth.
Gonzalez, Daniel Hector, Güttlein, Leandro, Viola, Ivana Lorena   +2 more
core   +1 more source

Tumor-associated macrophage-derived exosomal miR21-5p promotes tumor angiogenesis by regulating YAP1/HIF-1α axis in head and neck squamous cell carcinoma

Cellular and Molecular Life Sciences
Extracellular vesicles (EVs) have recently received increasing attention as essential mediators of communication between tumor cells and their microenvironments.
Q. Yan, Jing Liu, Yiding Liu, Zhihao Wen, Dong Jin, Fu Wang, Lu Gao   +6 more
semanticscholar   +1 more source

A novel antagonist of the CCL5/CCR5 axis suppresses the tumor growth and metastasis of triple-negative breast cancer by CCR5-YAP1 regulation

bioRxiv, 2023
Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer (BC) with a high mortality rate, and few effective therapeutic strategies are available. CCL5/CCR5 is an appealing immunotherapeutic target for TNBC.
Ling Chen, Guiying Xu, Xiaoxu Song, Lian Zhang, Chuyu Chen, Gang Xiang, Shuxuan Wang, Zijian Zhang, Fang Wu, Xuanming Yang, Lei Zhang, Xiaojing Ma, Jing Yu   +12 more
semanticscholar   +1 more source

Substrate Stress Relaxation Regulates Cell‐Mediated Assembly of Extracellular Matrix

Advanced Functional Materials, EarlyView.
Silicone‐based viscoelastic substrates with tunable stress relaxation reveal how matrix mechanics regulates cellular mechanosensing and cell‐mediated matrix remodelling in the stiff regime. High stress relaxation promotes assembly of fibronectin fibril‐like structures, increased nuclear localization of YAP and formation of β1 integrin‐enriched ...
Jonah L. Voigt, Jens Timmer, Elisabetta Ada Cavalcanti‐Adam   +2 more
wiley   +1 more source

At the center of cervical carcinogenesis: synergism between high-risk HPV and the hyperactivated YAP1

Molecular & Cellular Oncology, 2019
Human papillomavirus (HPV) is recognized as a necessary, but insufficient cause of cervical cancer. Recent in vitro and in vivo evidence from our laboratory demonstrate that hyperactivation of yes-associated protein 1 (YAP1) is sufficient to induce ...
Cheng Wang, John S Davis
doaj   +1 more source

Regulatory Mechanism of the Atypical AP-1-Like Transcription Factor Yap1 in Cryptococcus neoformans

mSphere, 2019
AP-1-like transcription factors play evolutionarily conserved roles as redox sensors in eukaryotic oxidative stress responses. In this study, we aimed to elucidate the regulatory mechanism of an atypical yeast AP-1-like protein, Yap1, in the stress ...
Yee-Seul So, Shinae Maeng, Dong-Hoon Yang, Hyelim Kim, Kyung-Tae Lee, Seong-Ryong Yu, Jennifer L. Tenor, Vinay K. Giri, Dena L. Toffaletti, Samantha Arras, James A. Fraser, John R. Perfect, Yong-Sun Bahn   +12 more
doaj   +1 more source

RGC1/RGC2 deletions cause increased sensitivity to oxidative stress in Saccharomyces cerevisiae, which can be overcome by constitutive nuclear Yap1 expression [PDF]

, 2016
Oxidative stress mechanism in yeast presents an innovative pathway to understand in creating the next generation of antifungal drugs. Rgc1 and Rgc2 are paralogous proteins that regulate the Fps1 glycerol channel in hyperosmotic stress.
Tsai, Michelle
core   +1 more source

Integrative Model of Oxidative Stress Adaptation in the Fungal Pathogen Candida albicans [PDF]

, 2015
Acknowledgments We are grateful to the Ian Fraser Cytometry Centre and our Mass Spetrometry and qPCR Facilities for help with the flow cytometry, glutathione and qRT-PCR assays, respectively.
Belmonte, Rodrigo C, Brown, Alistair J P, Cameron, Gary, Chandrasekaran, Komalapriya, de Moura, Alessandro P S, Gow, Neil A R, Grebogi, Celso, Haynes, Ken, Herrero De Dios, Carmen, Jacobsen, Mette D, Kaloriti, Despoina, Quinn, Janet, Romano, M Carmen, Thiel, Marco, Tillmann, Anna T, Yin, Zhinkang   +15 more
core   +3 more sources

Lineage segregation in human pre-implantation embryos is specified by YAP1 and TEAD1.

Human Reproduction, 2023
STUDY QUESTION Which processes and transcription factors specify the first and second lineage segregation events during human preimplantation development?
M. Regin, W. Essahib, Andrej Demtschenko, Delphine Dewandre, L. David, C. Gerri, Kathy K. Niakan, G. Verheyen, H. Tournaye, J. Sterckx, K. Sermon, H. Van de Velde   +11 more
semanticscholar   +1 more source