Results 111 to 120 of about 7,882 (190)

A genome-wide association study identifies four novel susceptibility loci underlying inguinal hernia. [PDF]

, 2015
Inguinal hernia repair is one of the most commonly performed operations in the world, yet little is known about the genetic mechanisms that predispose individuals to develop inguinal hernias.
Ahituv, Nadav, Avins, Andrew, Chen, David C, Eckalbar, Walter L, Hinds, David, Jorgenson, Eric, Makki, Nadja, Shen, Ling, Tian, Chao   +8 more
core   +2 more sources

YBX1-LDHB axis orchestrates pyruvate production from lactate to promote ICC initiation and development

Pharmacological Research
Previous work from our group established that Y-box binding protein 1 (YBX1) plays a pivotal role in the initiation and progression of intrahepatic cholangiocarcinoma (ICC); however, its specific biological functions and underlying regulatory mechanisms ...
Yong Liu, Fei Wang, Mi Zhang, Xiabing Shi, Lei Li, Tingjie Wang, Haifeng Zhang, Zhongyu Cheng, Xiangpan Li, Juan Chen, Chuanrui Xu   +10 more
doaj   +1 more source

The dynamic roles of TGF-β signalling in EBV-associated cancers [PDF]

, 2018
The transforming growth factor-β (TGF-β) signalling pathway plays a critical role in carcinogenesis. It has a biphasic action by initially suppressing tumorigenesis but promoting tumour progression in the later stages of disease.
Arvanitakis, Assoian, Cayrol, Chan, Christopher Dawson, Dalal, Derynck, Friedman, Gorsch, Gu, Ian Paterson, Kadin, Kumar, Lawrence Young, Lee Yap, Lo, MacDonald, Maeda, Moustakas, Newcom, Poh, Raftery, Segarini, Sekelsky, Sharmila Velapasamy, Yanagihara, Yap, Zhang   +27 more
core   +2 more sources

Biallelic mutations in nucleoporin NUP88 cause lethal fetal akinesia deformation sequence [PDF]

, 2018
Nucleoporins build the nuclear pore complex (NPC), which, as sole gate for nuclear-cytoplasmic exchange, is of outmost importance for normal cell function.
Bonnin, Edith, Cabochette, Pauline, Dickmanns, Achim, Fahrenkrog, Birthe, Ficner, Ralf, Filosa, Alessandro, Hezwani, Mohammed, Hoffmann, Katrin, Janssens, Sandra, Jühlen, Ramona, Kehlenbach, Ralph H, Komatsuzaki, Shoko, Laing, Nigel G, Lammens, Martin, Lombard, Marcus, Martinelli, Valérie, Martins, Nuno, Pirenne, Laurence, Port, Sarah, Ravenscroft, Gianina, Roets, Ellen, Spillner, Christiane, Supply, Lynn, Van Dorpe, Jo, Vanhollebeke, Benoit, Vermeersch, Marjorie   +25 more
core   +3 more sources

YBX1 Promotes Esophageal Squamous Cell Carcinoma Progression via m5C‐Dependent SMOX mRNA Stabilization

Advanced Science
The modification and recognition of 5‐methylcytosine (m5C) are involved in the initiation and progression of various tumor types. However, the precise role and potential mechanism of Y‐box‐binding protein 1 (YBX1) in esophageal squamous cell carcinoma ...
Liwen Liu, Yu Chen, Tao Zhang, Guangying Cui, Weiwei Wang, Guizhen Zhang, Jianhao Li, Yize Zhang, Yun Wang, Yawen Zou, Zhigang Ren, Wenhua Xue, Ranran Sun   +12 more
doaj   +1 more source

Cancer cells exploit an orphan RNA to drive metastatic progression. [PDF]

, 2018
Here we performed a systematic search to identify breast-cancer-specific small noncoding RNAs, which we have collectively termed orphan noncoding RNAs (oncRNAs).
A Fabregat, A Helwak, AA Margolin, AJ Minn, Alicia Y. Zhou, AM Ainsztein, Andrei Goga, AR Kodahl, AR Quinlan, B Kim, B Langmead, Bruce Culbertson, C Roth, CI Wu, CJ David, D Huo, D Ray, DK Simanshu, DN Cooper, EL Nostrand Van, H Goodarzi, H Goodarzi, H Goodarzi, H Goodarzi, Hani Goodarzi, JM Loo, Johnny X. Yu, K Cuk, L Fish, Lisa Fish, LY Chen, M Rehmsmeier, MI Love, MJ Moore, NN Hooten, O Elemento, PD Bos, R Bhargava, R Ren, RK Lin, RO Bak, S Kishore, S Vanharanta, SF Tavazoie, Steven Zhang, T Fiskaa, W Zhou, X Wu, YCT Yang, YS DeRose   +49 more
core   +2 more sources

In silico analysis of overall survival with YBX1 in male and female solid tumours

Scientific Reports
The Y-box binding protein-1 (YBX1) gene codes for a multifunctional oncoprotein that is increasingly being linked to the regulations of many aspects of cancer cell biology.
David Robert Grimes, Treewut Rassamegevanon, Laure Marignol   +2 more
doaj   +1 more source

A key variant in the cis-regulatory element of flowering gene Ghd8 associated with cold tolerance in rice. [PDF]

, 2019
Variations in the gene promoter play critical roles in the evolution of important adaptive traits in crops, but direct links of the regulatory mutation to the adaptive change are not well understood.
Fan, Kai, Gong, Rong, Wang, Peng, Xiong, Yin, Yang, Ying, Yu, Sibin   +5 more
core  

Changes in epithelial proportions and transcriptional state underlie major premenopausal breast cancer risks [PDF]

, 2018
The human breast undergoes lifelong remodeling in response to estrogen and progesterone, but hormone exposure also increases breast cancer risk. Here, we use single-cell analysis to identify distinct mechanisms through which breast composition and cell ...
Borowsky, Alexander D., Caruso, Joseph A., Desai, Tejal A., Gartner, Zev J., Gascard, Philippe, McGinnis, Christopher S., Murrow, Lyndsay M., Phong, Kiet, Thomson, Matthew, Tlsty, Thea, Weber, Robert J.   +10 more
core   +1 more source

Multi-omic analyses of m5C readers reveal their characteristics and immunotherapeutic proficiency

Scientific Reports
5-methylcytosine (m5C) is a post-transcriptional RNA modification identified, m5C readers can specifically identify and bind to m5C. ALYREF and YBX1 as members of m5C readers that have garnered increasing attention in cancer research.
Rui Xu, Yue Wang, Ye Kuang
doaj   +1 more source