Results 41 to 50 of about 796,939 (318)

Identification of a small RhoA GTPase inhibitor effective in fission yeast and human cells

Open Biology, 2023
The Rho GTPase family proteins are key regulators of cytoskeletal dynamics. Deregulated activity of Rho GTPases is associated with cancers and neurodegenerative diseases, and their potential as drug targets has long been recognized. Using an economically
Jun Morishita, Paul Nurse
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

urg1: A Uracil-Regulatable Promoter System for Fission Yeast with Short Induction and Repression Times [PDF]

, 2008
Background. The fission yeast Schizosaccharomyces pombe is a popular genetic model organism with powerful experimental tools. The thiamine-regulatable nmt1 promoter and derivatives, which take > 15 hours for full induction, are most commonly used for ...
Mata, J, Luis López-Maury, Juan Mata, Lopez-Maury, L, Watt, Stephen, Bähler Jürg, Marguerat, Samuel, Mata, Juan, Watt, S, Bahler, J, Gavin Burns, López Maury, Luis, Burns, Gavin, Stephen Watt, Mata Juan, Jürg Bähler, Marguerat, S, Samuel Marguerat, Marguerat Samuel, López-Maury Luis, Burns Gavin, Burns, G, Watt Stephen, Bähler, Jürg Ürg   +23 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

3 '-processing of yeast tRNA(Trp) precedes 5 '-processing [PDF]

, 2003
Previous analyses of eukaryotic pre-tRNAs processing have reported that 5'-cleavage by RNase P precedes 3'-maturation. Here we report that in contrast to all other yeast tRNAs analyzed to date, tRNA(Trp) undergoes 3'-maturation prior to 5'-cleavage ...
Tollervey, D, Kufel, J
core   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

SysBioChalmers/yeast-GEM: yeast 8.1.2

, 2018
<ul> <li>New features: <ul> <li><code>saveYeastModel.m</code> now checks if the model is a valid SBML structure; if it isn't it will error (PR <a href="https://github.com/SysBioChalmers/yeast-GEM ...
Mihail Anton, Christian Lieven, Feiran Li, Hongzhong Lu, Thomas Pfau, Benjamín J. Sánchez, Eduard J. Kerkhoven   +6 more
core   +1 more source

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

FEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez, Mikael Oliveberg, Peter Brzezinski   +2 more
wiley   +1 more source

Lactiplantibacillus plantarum P16 mitigated murine colitis through modulation of immune response and gut microbiota

AMB Express
Probiotics show potential for preventing and mitigating inflammatory bowel disease (IBD), though their efficacy and mechanisms are strain-specific. This study aimed to elucidate the protective mechanism of Lactiplantibacillus (L.) plantarum P16 against ...
Zhixian Chen, Qian Cheng, Xiaoli Zhang, Zhouhuang Sheng, Lei Shi, Yan Zhang   +5 more
doaj   +1 more source

Apoptosis in Yeasts [PDF]

IUBMB Life, 2003
AbstractAlthough yeasts lack some elements of the complex apoptotic machinery of metazoan cells, recent studies show that many features of apoptosis, including a caspase‐like activity, can be induced in these organisms by DNA damage and other apoptotic triggers.
Martin, Weinberger, Lakshmi, Ramachandran, William C, Burhans   +2 more
openaire   +2 more sources