Results 41 to 50 of about 1,263,084 (307)
Identification of a small RhoA GTPase inhibitor effective in fission yeast and human cells
Open Biology, 2023 The Rho GTPase family proteins are key regulators of cytoskeletal dynamics. Deregulated activity of Rho GTPases is associated with cancers and neurodegenerative diseases, and their potential as drug targets has long been recognized. Using an economically
Jun Morishita, Paul Nurse
doaj +1 more source
The effects of metformin therapy on BMI and biochemical markers among overweight children and adolescents [abstract] [PDF]
, 2010 Introduction: In the United States, overweight adolescents are likely to continue to gain weight over time and are more likely to become overweight adults. High rates of child and adolescent obesity leave physicians searching for ways to stop this trend.
Yeast, Carrie
core
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Coenzyme Q10 deficiencies: pathways in yeast and humans. [PDF]
, 2018 Coenzyme Q (ubiquinone or CoQ) is an essential lipid that plays a role in mitochondrial respiratory electron transport and serves as an important antioxidant.
Awad, Agape M +5 more
core
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
AMB ExpressProbiotics show potential for preventing and mitigating inflammatory bowel disease (IBD), though their efficacy and mechanisms are strain-specific. This study aimed to elucidate the protective mechanism of Lactiplantibacillus (L.) plantarum P16 against ...
Zhixian Chen +5 more
doaj +1 more source
The geographic distribution of saccharomyces cerevisiae isolates within three Italian neighboring winemaking regions reveals strong differences in yeast abundance, genetic diversity and industrial strain dissemination [PDF]
, 2017 In recent years the interest for natural fermentations has been re-evaluated in terms of increasing the wine terroir and managing more sustainable winemaking practices.
Almeida +63 more
core +4 more sources
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Shipin yu jixieObjectiveTo conduct flow field simulation analysis on an 80-ton bubble column bioreactor for equipment improvement and fermentation efficiency enhancement.MethodsComputational fluid dynamics is resorted to numerical simulation of gas-liquid two-phase ...
WANG Long +4 more
doaj +1 more source
Impact of particle size reduction on high gravity enzymatic hydrolysis of steam-exploded wheat straw
SN Applied Sciences, 2021 Article Highlights Fiber size reduction benefits enzymatic high gravity hydrolysis of steam-exploded wheat straw. Small fiber size of ≤ 2.5 mm enables saccharification at 35% w/w solid loadings.
Luis Hoppert, Daniel Einfalt
doaj +1 more source