Results 241 to 250 of about 132,198 (316)

Enhancing Enzyme Activity With Mutation Combinations Guided by Few‐Shot Learning and Causal Inference

Angewandte Chemie, EarlyView.
We present an integrated workflow that predicts activity‐enhancing mutation combinations from minimal experimental data. By proposing in vivo unit yield (yield/expression) as a surrogate for kcat/Km through causal inference, and visualizing local activity landscape, it effectively guides product yield improvement. ABSTRACT Designing enzyme sequences to
Lin Guo, Xiaoguang Yan, Yali Lu, Shengxin Nie, Mingyue Ge, Yukun Li, Weiguo Li, Xiaochun Zhang, Dongmei Liang, Yihan Zhao, Hongxiao Tan, Xiling Chen, Shilong Fan, Yefeng Tang, Jianjun Qiao, Boxue Tian   +15 more
wiley   +2 more sources

Thermotolerant insect-associated selective pressure may drive increased lipid metabolic plasticity and emerging pathogenic potential in yeasts. [PDF]

Front Microbiol
Van Baalen C, Zhou N, Boekhout T, Sebolai OM, Albertyn J, Pohl CH.   +5 more
europepmc   +1 more source

Correction to “Evolution and Domestication of a Novel Biosynthetic Gene Cluster Contributing to the Flavonoid Metabolism and High‐Altitude Adaptability of Plants in the Fagopyrum Genus”

Advanced Science, EarlyView.
wiley   +1 more source

GS‐9620 alleviates psoriasis‐like inflammation by regulating autophagy in keratinocytes

Animal Models and Experimental Medicine, EarlyView.
Psoriasis is an immune‐mediated inflammatory disease of the skin characterized by excessive proliferation and abnormal differentiation of keratinocytes. GS‐9620 can increase the expression of ATG5, ATG7 and ATG16L1, thereby regulating the autophagy of keratinocytes and inhibiting the secretion of related inflammatory factors.
Yansi Lyu, Wei Zhou, Pei Zhang, Chen Lin, Xin Wen, Zigang Zhao, Guoqiang Zhang, Qian Zhang, Si Chen   +8 more
wiley   +1 more source

Novel killer yeasts and toxins from the gardens of fungus-growing ants. [PDF]

Appl Environ Microbiol
Bizarria R, Creagh JW, Corrêa Dos Santos RA, Givens LL, Coss SA, Badigian TJ, Chavez AV, Tekle RT, Fredstrom N, Ytreberg FM, Dunham MJ, Rodrigues A, Rowley PA.   +12 more
europepmc   +1 more source

Selenium Nanomaterials for Wound Healing: Synergistic Strategies from Anti‐Infection to Tissue Regeneration

Advanced NanoBiomed Research, EarlyView.
Selenium nanoparticles (SeNPs) are emerging as multifunctional platforms for wound healing, integrating antimicrobial, anti‐inflammatory, and proregenerative activities. This review summarises key mechanisms and recent advances in SeNP‐enabled composite dressings, immunomodulatory nanocomposites, microenvironment‐responsive hydrogels, photothermal and ...
Yangxia Chen, Xiaoshuang Liang, Sirui Li, Shuoshan Li, Wei Liu, Yingping Lin, Siqi Li, Zehang Zhang, Judun Zheng, Tianfeng Chen, Rongyi Chen   +10 more
wiley   +1 more source

Clinical Significance of Rare Non-<i>Candida</i> Yeasts in Pediatric Fungemia: A Retrospective Analysis. [PDF]

J Fungi (Basel)
Arga G, Özdemir H, Öcal D, Somuncu E, Akat H, Penezoğlu DN, İnceli HB, Köstekçi YE, Çakmaklı HF, Havan M, Özdemir Sİ, Kendirli T, Ertem M, Taçyıldız N, Çiftçi E.   +14 more
europepmc   +1 more source

Omics-Guided Construction of Microbial Consortia for Reproducible Traditional Fermented Foods and Beverages. [PDF]

Foods
Song D, Yang L, Zhang C.
europepmc   +1 more source

Degradation Mechanisms, Encapsulation‐Based Stabilization, and Analytical Detection of Vitamin A

Journal of the American Oil Chemists' Society, EarlyView.
ABSTRACT Vitamin A is an important lipid‐soluble micronutrient essential for vision, immune function, and overall growth and development. However, vitamin A is unstable and susceptible to environmental factors because of its conjugated structure and inherent chemical reactivity.
Latheesha Abeywardana, Thambaramala V. Gamage, Tanoj K. Singh, Shuaifei Zhao, Amy Logan, Lingxue Kong   +5 more
wiley   +1 more source

Community assembly and aroma contribution of <i>Hanseniaspora</i> yeasts in spontaneous fermentation of Cabernet Sauvignon grapes from four regions in Northwest China. [PDF]

Food Chem X
Fan B, Chang Y, Zheng M, Han J, Tao Y, Zhao H, Hu K.   +6 more
europepmc   +1 more source