Results 91 to 100 of about 614,658 (333)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
‘Goldone’, a Yellow - fleshed Kiwifruit Cultivar with Large Fruit Size
Horticultural Science and Technology, 2017 In Korea, kiwifruit is grown within a limited region on the southern coast where the climate is warm. Since the yellow - fleshed kiwifruit variety, ‘Hort16A’, first became commercially available, we have focused on breeding additional yellow - fleshed kiwifruits.
Yong-Bum Kwack +4 more
openaire +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Breeding of an early-middle season and yellow-fleshed flat peach Zhongpan 102 [PDF]
Guoshu xuebaoFlat peach is originated in China and popular for its unique flat shape and excellent flavor. However, for a very long time there were not so many cultivars for growers to choose because the fruit apex of most cultivars did not close well and the ...
NIU Liang +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Plant, Soil and Environment, 2010 In precise field trials in the Czech Republic from 2004-2008 the impact of location conditions, varieties with yellow, purple and red flesh and mineral fertilization on the content of total polyphenols (TP) and chlorogenic acid was investigated.
K. Hamouz +5 more
doaj +1 more source
Pineapple plant named "RL 41" [PDF]
, 2002 An Ananas comosus variety is provided that forms attractive orange-red oval to cylindrical fruit with relatively flat fruitlets. The fruit is substantially uniformly colored from top to bottom when ripe even in the absence of chemical treatment with a ...
Loison, Chantal
core
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source