Results 101 to 110 of about 617,261 (321)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Breeding of an early-middle season and yellow-fleshed flat peach Zhongpan 102 [PDF]

Guoshu xuebao
Flat peach is originated in China and popular for its unique flat shape and excellent flavor. However, for a very long time there were not so many cultivars for growers to choose because the fruit apex of most cultivars did not close well and the ...
NIU Liang, ZENG Wenfang, PAN Lei, CUI Guochao, LU Zhenhua, WANG Zhiqiang   +5 more
doaj   +1 more source

Pigment analysis by Raman microscopy and portable X-ray fluorescence (pXRF) of thirteenth to fourteenth century illuminations and cuttings from Bologna [PDF]

, 2016
Non-destructive pigment analysis by Raman microscopy (RM) and portable X-ray fluorescence (pXRF) has been carried out on some Bolognese illuminations and cuttings chosen to represent the beginnings, evolution and height of Bolognese illuminated ...
Chaplin, Tracey D., Clark, Robin J.H., Gibbs, Robert, Jones, Richard   +3 more
core   +1 more source

‘Goldone’, a Yellow - fleshed Kiwifruit Cultivar with Large Fruit Size

Horticultural Science and Technology, 2017
In Korea, kiwifruit is grown within a limited region on the southern coast where the climate is warm. Since the yellow - fleshed kiwifruit variety, ‘Hort16A’, first became commercially available, we have focused on breeding additional yellow - fleshed kiwifruits.
Yong-Bum Kwack, Hong Lim Kim, Jae Han Lee, Kyeong Ho Chung, Won Byoung Chae   +4 more
openaire   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Effect of natural and growing conditions on the contentof phenolics in potatoes with different flesh colour

Plant, Soil and Environment, 2010
In precise field trials in the Czech Republic from 2004-2008 the impact of location conditions, varieties with yellow, purple and red flesh and mineral fertilization on the content of total polyphenols (TP) and chlorogenic acid was investigated.
K. Hamouz, J. Lachman, K. Hejtmánková, K. Pazderů, M. Čížek, P. Dvořák   +5 more
doaj   +1 more source

Growing Potatoes in the Alaska Garden [PDF]

, 1984
Potatoes are a great crop for Alaska gardens because they are easy to grow and have a high yield per square foot. This publication includes tips on planting, growing, harvesting and storing potatoes as well as suggestions for cooking and preparing them ...
Smeenk, Jeff
core  

The genome evolution and domestication of tropical fruit mango [PDF]

, 2020
Background: Mango is one of the world’s most important tropical fruits. It belongs to the family Anacardiaceae, which includes several other economically important species, notably cashew, sumac and pistachio from other genera.
Bai, Beibei, Cahoon, Edgar B., Chen, Huarui, Chen, Yeyuan, Dang, Zhiguo, Gai, Jiangtao, Gao, Aiping, Gao, Shenghan, Gong, Deyong, Hu, Songnian, Huang, Guodi, Huang, Jianfeng, Li, Qian, Luo, Ruixiong, Luo, Yingfeng, Ni, Zhangguang, Tan, Xinyu, Tang, Kexuan, Wang, Peng, Wang, Sen, Wei, Junya, Wu, Shuangyang, Yang, Meng, Ye, Xiuxu, Zhang, Bing, Zhang, Huangkai, Zhao, Zhichang, Zhu, Guopeng, Zhu, Min   +28 more
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source