Results 171 to 180 of about 42,623 (235)

Selective modulation of NaV channel gating counteracts aberrant hyperexcitability and rescues motor function and survival in a model of spinal muscular atrophy

British Journal of Pharmacology, EarlyView.
Background and Purpose Spinal muscular atrophy (SMA) is a motor neuron disease caused by SMN1 gene loss, leading to reduced survival motor neuron (SMN) protein and progressive motor neuron degeneration. Although SMN‐restoring therapies improve outcomes, residual disease burden and non‐curative efficacy underscore the need for complementary treatments ...
Fernanda C. Cardoso, Jessica A. I. Muller, Yougang Zhang, Jean Giacomotto   +3 more
wiley   +1 more source

Dietary melatonin and its benefits on cardiovascular disease

British Journal of Pharmacology, EarlyView.
Cardiovascular disease remains the leading cause of mortality globally, with a disproportionate burden in low‐ and middle‐income countries. Melatonin, a hormone primarily produced by the pineal gland, exhibits notable antioxidant, anti‐inflammatory and immunomodulatory properties that may confer cardiovascular benefits.
Karabo Tisane, Carmelita Abrahams, Sandrine Lecour   +2 more
wiley   +1 more source

Family meals for future health: A life‐course approach to type 2 diabetes risk reduction after gestational diabetes

Diabetic Medicine, EarlyView.
The potential role of family meals in a life‐course approach to type 2 diabetes risk‐reduction after gestational diabetes. Abstract Aims Gestational diabetes (GDM) more than doubles maternal and child risk of type 2 diabetes (T2D). Post‐GDM, a life‐course approach to T2D risk reduction includes family nutrition‐focused health promotion.
Eloise Litterbach, Alison C. Spence, Georgia Middleton, Jane Speight, Elizabeth Holmes‐Truscott   +4 more
wiley   +1 more source

Tachinidae (Diptera) as Floral Visitors and Pollinators in Natural and Managed Systems

Entomologia Experimentalis et Applicata, EarlyView.
We review the roles of bristle flies (Tachinidae) as pollinators in natural and managed systems. We find that most tachinid genera visit flowers and that floral‐adapted mouthparts have evolved repeatedly many times in the family. We review patterns of floral specificity and assess the efficacy of tachinids as pollinators with case studies.
John O. Stireman III, Pierfilippo Cerretti   +1 more
wiley   +1 more source

‘Elbow grease and yellow soap’: Housework time in working‐class households in late‐nineteenth and early twentieth‐century Britain

The Economic History Review, EarlyView.
Abstract Housework is central to feminist calls for recognition of women's work, economic histories explaining the sexual division of labour, and claims regarding the progressive role of scientific knowledge. Yet little is known about the time it actually took. We address this lacuna.
Sara Horrell, Jane Humphries
wiley   +1 more source

Effect of chitosan‐containing desensitizers applied prior to bleaching on the physical properties of enamel

European Journal of Oral Sciences, EarlyView.
Abstract This in vitro study evaluated the effects of adding chitosan (Chi) to desensitizing agents applied before dental bleaching on enamel properties. Bovine enamel specimens were allocated to seven groups (n = 12): no treatment (negative control), 2% NaF (positive control), 2% NaF + 2% Chi, 2% NaF + 5% Chi, 2% NaF + 5% KNO3, 2% NaF + 5% KNO3 + 2 ...
Júlia Barbato, Luís Otávio Passos, Carolina Meneghin Barbosa, Marcos Roberto de Lima Benati, Renata Siqueira Scatolin, Ana Carolina Cabral Roque, Tatiane Cristina Dotta, Waldemir Francisco Vieira‐Junior, Laura Nobre Ferraz   +8 more
wiley   +1 more source

Constrictions and shear stress are key determinants of amyloidogenic light chain (AL) amyloidosis

The FEBS Journal, EarlyView.
In this study, we investigate how flow constrictions and shear stress trigger cardiac antibody light chain (AL) fibril formation and deposition. We mimic the mechanical forces exerted by the heart and the microvasculature network using a mini‐peristaltic pump setup and a grid‐type microchannel network, respectively.
Yuji Goto, Keiichi Yamaguchi, Kichitaro Nakajima, Ikuko Yumen, Ruiming He, Hirokazu Matsuda, Tetsuichi Wazawa, Takeharu Nagai, Nobuhiro Tsukada, Suguru Yamamoto, Johannes Buchner, Hirotsugu Ogi   +11 more
wiley   +1 more source

Population genetic analysis of the endangered Mottled Duskywing butterfly (Erynnis martialis) informs species reintroduction

Insect Conservation and Diversity, EarlyView.
Mottled Duskywing (Erynnis martialis) populations had moderate levels of genetic diversity at microsatellites with expected heterozygosity ranging from 0.43 to 0.58, and populations more than 10 km apart were differentiated from one another. Weak patterns of isolation by distance and low effective population sizes suggest that all but the largest ...
Shayla L. Kroeze, Gard W. Otis, Jessica E. Linton, D. Ryan Norris, Richard Westwood, Adrienne L. E. Brewster, Nusha Keyghobadi   +6 more
wiley   +1 more source

Lignan‐rich Norway spruce (Picea abies) resin extract exhibits anti‐inflammatory, skin‐regenerative and anti‐acne effects: In vitro, in silico, biocompatibility and exploratory clinical findings

International Journal of Cosmetic Science, EarlyView.
GA text A 30% Picea abies resin extract cream combined antimicrobial, anti‐inflammatory and early pro‐repair activities relevant to acne‐prone skin. The formulation showed strong activity against Cutibacterium acnes, reduced inflammatory cytokines and demonstrated promising tolerability and efficacy in an exploratory in‐use study. Abstract Objective To
Simone Parrotta, Kamilla Yamileva, Laura Punakallio, Maryam Ghanbarirad, Evgen Multia   +4 more
wiley   +1 more source

The Complex World of Toothpaste Diversity, Meeting Patient Clinical Needs. An Umbrella Review

International Journal of Dental Hygiene, EarlyView.
ABSTRACT Background Amidst numerous recent advancements in toothpaste formulations and active ingredients, some clinicians may believe all toothpastes are similar despite differences in their active ingredients and corresponding clinical application.
Jeanie Suvan, Crystal Marruganti
wiley   +1 more source