Results 51 to 60 of about 20,539 (180)

Molecular Dynamics Analysis of Inhibitor Binding Interactions in the Vibrio cholerae Respiratory Complex NQR

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 2, Page 649-659, February 2026.
ABSTRACT The sodium‐pumping ubiquinone oxidoreductase sodium pumping quinone reductase (NQR) is an important enzyme in the respiratory chain of multiple pathogenic gram‐negative bacteria. NQR has been proposed as a viable antibiotic target due to its importance in supporting energy‐consuming reactions and its absence in human cells.
Joseph. A. DePaolo‐Boisvert, Karina Tuz, David. D. L. Minh, Oscar X. Juarez   +3 more
wiley   +1 more source

Development of Metagenomic Methods for Health Monitoring of Endangered Species Using Fecal Samples

Evolutionary Applications, Volume 19, Issue 2, February 2026.
ABSTRACT Metagenomic analysis of fecal samples is emerging as a powerful tool for monitoring endangered species, particularly in assessing the burden of pathogens and parasites that can threaten population viability. However, accurate identification in non‐model species remains challenging due to the frequent absence of host‐specific pathogen reference
Román Sapino, Ángel Fernández‐González, Jose Castresana   +2 more
wiley   +1 more source

Virulence Regulation and Lifestyle Transitions: The Role of c‐di‐GMP and Two‐Component Systems in Erwinia amylovora and Their Evolutionary Context Within Enterobacterales

Molecular Plant Pathology, Volume 27, Issue 2, February 2026.
Erwinia amylovora infects apple blossoms by activating the T3SS, then spreads systemically via amylovoran‐mediated biofilms. Transitions between motile and sessile states are regulated by key two‐component systems and c‐di‐GMP. This review summarises infection biology, virulence factors, regulatory networks and evolutionary insights underlying fire ...
Dhirendra Niroula, Kalyani Bhandari, George W. Sundin, Janak R. Joshi   +3 more
wiley   +1 more source

Intraspecific Diversity ofYersinia pestis [PDF]

Clinical Microbiology Reviews, 2004
SUMMARYIncreased interest in the pathogenic potential ofYersinia pestishas emerged because of the potential threats from bioterrorism. Pathogenic potential is based on genetic factors present in a population of microbes, yet most studies evaluating the role of specific genes in virulence have used a limited number of strains. ForY.
Andrey P, Anisimov, Luther E, Lindler, Gerald B, Pier   +2 more
openaire   +3 more sources

Quality and Safety Evaluation of Conventional and Organic Eggs From Supermarkets and Bakeries in Different Areas of Lahore, Pakistan

Food Safety and Health, Volume 4, Issue 1, Page 100-111, January 2026.
The findings of this study raised serious concerns about egg handling, storage and microbial safety in local markets of Pakistan. It was concluded that the eggs available in Lahore markets exhibited significant deviations from USDA quality standards, posing potential health risks. ABSTRACT Eggs are considered a highly nutritious food in the human diet,
Ayesha Noor‐ul‐Ain, Aqsa Akhtar, Muhammad Moeen Butt, Nauman Khalid   +3 more
wiley   +1 more source

Omics strategies for revealing Yersinia pestis virulence

Frontiers in Cellular and Infection Microbiology, 2012
Omics has remarkably changed the way we investigate and understand life. Omics differs from traditional hypothesis-driven research because it is a discovery-driven approach.
Ruifu eYang, Zongmin eDu, Yanping eHan, Lei eZhou, Yajun eSong, Dongsheng eZhou, Yujun eCui   +6 more
doaj   +1 more source

RePol: A high‐throughput screen for optimizing membrane protein solubilization and purification using polymers

Protein Science, Volume 35, Issue 1, January 2026.
Abstract Extraction and purification of membrane proteins has for a long time represented a significant challenge. Polymer‐based extraction methods, like those using styrene maleic acid co‐polymers have provided a fertile approach to generate samples that include the local lipid environment surrounding the protein.
Adam Evans, Bethan Kelly, Pooja Sridhar, Alice J. Rothnie, Naomi L. Pollock, Philip M. Ireland, David I. Roper, Tim R. Dafforn   +7 more
wiley   +1 more source

Iron availability and oxygen tension regulate the Yersinia Ysc type III secretion system to enable disseminated infection.

PLoS Pathogens, 2019
The enteropathogen Yersinia pseudotuberculosis and the related plague agent Y. pestis require the Ysc type III secretion system (T3SS) to subvert phagocyte defense mechanisms and cause disease.
Diana Hooker-Romero, Erin Mettert, Leah Schwiesow, David Balderas, Pablo A Alvarez, Anadin Kicin, Azuah L Gonzalez, Gregory V Plano, Patricia J Kiley, Victoria Auerbuch   +9 more
doaj   +1 more source

Advances in Microbial Diagnostics: Machine Learning and Nanotechnology for Zoonotic Disease Control

WIREs Nanomedicine and Nanobiotechnology, Volume 18, Issue 1, January/February 2026.
This review highlights how integrating machine learning with nanotechnology enables enhanced diagnostics, personalized treatments, and the prediction of outbreaks for zoonotic diseases, offering a unified framework to advance global health. ABSTRACT Zoonotic diseases pose significant global health threats, with microbial pathogens, including bacteria ...
Narges Lotfalizadeh, Cinzia Santucciu, Valentina Chisu, Helia Sepahvand, Abbas Rahdar, Razieh Behzadmehr, Octavio Luiz Franco, Guettari Moez, Luiz Fernando Romanholo Ferreira   +8 more
wiley   +1 more source

Analysis of 3800-year-old Yersinia pestis genomes suggests Bronze Age origin for bubonic plague

Nature Communications, 2018
Yersinia pestis has caused infections (plague) in humans since the Early Bronze Age (5000 years ago). Here, Spyrou et al. reconstruct Y. pestis genomes from Late Bronze Age individuals, and find genomic evidence compatible with flea-mediated transmission
Maria A. Spyrou, Rezeda I. Tukhbatova, Chuan-Chao Wang, Aida Andrades Valtueña, Aditya K. Lankapalli, Vitaly V. Kondrashin, Victor A. Tsybin, Aleksandr Khokhlov, Denise Kühnert, Alexander Herbig, Kirsten I. Bos, Johannes Krause   +11 more
doaj   +1 more source