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Preliminary study on the cellular and molecular mechanisms of Cms1 ribosomal small subunit homolog promoting hepatocellular carcinoma progression via activation of the homolog family member A/yes-associated protein 1 signaling pathway. [PDF]

Cytojournal
Zheng Y, Wang A, Yu S, Wei B, Lyu X.
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Yes-associated protein (YAP) functions as a tumor suppressor in breast

Cell Death & Differentiation, 2008
Yes-associated protein (YAP) has been shown to positively regulate p53 family members and to be negatively regulated by the AKT proto-oncogene product in promoting apoptosis. On the basis of this function and its location at 11q22.2, a site of frequent loss of heterozygosity (LOH) in breast cancer, we investigated whether YAP is a tumor suppressor in ...
Yuan, M, Tomlinson, V, Lara, R, Holliday, D, Chelala, C, Harada, T, Gangeswaran, R, Manson-Bishop, C, Smith, P, Danovi, SA, Pardo, O, Crook, T, Mein, CA, Lemoine, NR, Jones, LJ, Basu, S   +15 more
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Histopathological expression of Yes-associated protein in neonatal cholestasis

Clinics and Research in Hepatology and Gastroenterology, 2020
Biliary atresia (BA) is a common cause of persistent neonatal cholestasis and liver transplantation in the pediatric population. Yes-associated protein (YAP) has also been shown to be necessary for development of bile ducts and adaptive responses within the gastrointestinal tract. We aimed to evaluate the YAP expression in liver tissues of infants with
Sahar Shahin Abo-Zeinah, Behairy Behairy, Mohsen Hasan Hussein, Mohammad Ahmed Khedr, Dina Shehata El Azab, Nermin Mohammed Adawy, Haidy Mohammed Zakaria   +6 more
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Agrin Yes-associated Protein Promotes the Proliferation of Epicardial Cells

Journal of Cardiovascular Pharmacology, 2021
Abstract: Embryonic epicardial cells make an important contribution to cardiac development. However, their proliferation mechanism is still unclear. Epicardial cells from E12.5 fetal hearts were used in our study. Agrin was used to treat these cells.
Xiaodong, Jing, Bin, Liu, Songbai, Deng, Jianlin, Du, Qiang, She   +4 more
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Mechanosensitive Yes-Associated Protein in Human Skin during Aging

Advances in Gerontology, 2020
The aim of this work was to examine the content of Yes-associated protein (YAP) in fibroblasts and blood microvessels of human dermis from the development until deep aging (from 20 weeks of pregnancy until 85 years old), and defining of a role of YAP in age-dependent changes in the number of fibroblasts and blood microvessels in the dermis.
A G, Gunin, N N, Golubtzova, N K, Kornilova   +2 more
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Regulation of Yes-Associated Protein by Laminar Flow

Annals of Vascular Surgery, 2018
The cells lining the endothelium of blood vessels are recognized as playing critical roles in vascular health and disease. The mechanisms that regulate endothelial cells (ECs) proliferation and release of mediators remain poorly understood but represent a potential source of disease modulation.
Gautham, Chitragari, Sherif Y, Shalaby, Brandon J, Sumpio, Jiro, Kurita, Bauer E, Sumpio   +4 more
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Synthetic molecules targeting yes associated protein activity as chemotherapeutics against cancer

Chemical Biology & Drug Design, 2021
AbstractThe Hippo signaling pathway extorts several signals that concomitantly target the activity of transcriptional cofactor yes associated protein (YAP). YAP is a key regulator that elicits signature gene expression by coupling with transcriptional enhanced associate domain (TEAD) family of transcriptional factors.
Ramsha Iftikhar, Ameer Fawad Zahoor, Muhammad Irfan, Azhar Rasul, Faiza Rao   +4 more
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Yes-associated protein promotes bone healing after tooth extraction in mice

Biochemical and Biophysical Research Communications, 2022
In this study, a tooth extraction socket model was established in vivo, and Lv-YAP1-GFP, Lv-GFP or saline was injected locally into the extraction socket. Expression of markers of osteogenesis, osteoclastogenesis, adipogenesis, proliferation and apoptosis explore whether YAP can promote bone formation in the process of tooth extraction socket healing ...
Zhiwei Cao, Haitao Shi, Liru Hu, Kun Zhang, Xiaohui Zhang, Jian Pan   +5 more
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Expression of Yes-Associated Protein in Cervical Squamous Epithelium Lesions

International Journal of Gynecological Cancer, 2014
Yes-associated protein (YAP) was defined as a candidate oncogene in multiple cancers. Yet, the role of YAP in cervical cancer is largely unknown. The aim of this study was to determine whether YAP could be used as a predictive biomarker in cervical precancerous lesions.Immunohistochemical analysis of YAP expression was performed in 10 chronic ...
Hong, Xiao, Lina, Wu, Huixia, Zheng, Ning, Li, Huili, Wan, Gang, Liang, Yanglu, Zhao, Jianfang, Liang   +7 more
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