Results 111 to 120 of about 4,030,490 (290)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Gamma ray emission from embedded young massive star clusters unveiled by Fermi-LAT [PDF]

EPJ Web of Conferences
Massive star clusters (SCs) have been proposed as additional contributors to Galactic Cosmic rays (CRs), to overcome the limitations of supernova remnants (SNR) to reach the highest energy end of the Galactic CR spectrum.
Peron Giada, Morlino Giovanni, Amato Elena, Menchiari Stefano   +3 more
doaj   +1 more source

Neurologic Manifestations of Long COVID Affect Adult Females More Severely Than Males

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize differences in neurologic manifestations of postacute sequelae of SARS‐CoV‐2 infection (Neuro‐PASC) between females and males. Methods Cross‐sectional study of the first consecutive 261 posthospitalization Neuro‐PASC (PNP) and 2068 nonhospitalized Neuro‐PASC (NNP) patients evaluated at the Neuro‐COVID clinic between ...
Hannah Kopinsky, Melissa Lopez, Janet Miller, Millenia Jimenez, Eric M. Liotta, Igor J. Koralnik   +5 more
wiley   +1 more source

The Impact of Metallicity and Dynamics on the Evolution of Young Star Clusters

, 2014
The early evolution of a dense Young Star Cluster (YSC) depends on the intricate connection between stellar evolution and dynamical processes. Thus, N-body simulations of YSCs must account for both aspects.
Trani, A. A., Bressan, A., Mapelli, M.
core  

Quantitative MRI Uncovers Subtle Cortical Damage in Myelin Oligodendrocyte Glycoprotein Antibody‐Associated Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine whether myelin‐sensitive quantitative MRI reveals microstructural abnormalities in normal‐appearing cortex (NACtx) in myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), indicating that conventional MRI underestimates remission residual cortical injury.
Valentina Camera, Agnese Tamanti, Silvia Messina, Nicola Dall'Osto, Teresa Maltempo, Stefano Ziccardi, Matteo Foschi, Maria Grazia Piscaglia, Diana Ferraro, Francesco Crescenzo, Francesca Rossi, Albulena Bajrami, Sabrina Marangoni, Damiano Marastoni, Francesca Benedetta Pizzini, Maria Isabel Leite, Roberta Magliozzi, Patrick Waters, Massimiliano Calabrese, Jacqueline Palace, Ruth Geraldes   +20 more
wiley   +1 more source

Neighborhood Socioeconomic Status and Short‐Term Functional Outcomes in Systemic Lupus Erythematosus

Arthritis Care &Research, EarlyView.
Objective Individuals with systemic lupus erythematosus (SLE) can accumulate functional status (FS) impairment. We evaluated the association between neighborhood socioeconomic disadvantage, as measured by the Area Deprivation Index (ADI), and FS in a national SLE sample.
Baljeet Rai, Jessica Fitzpatrick, Jing Li, Eric Roberts, Patricia Katz, Laura Plantinga, Gabriela Schmajuk, Jinoos Yazdany   +7 more
wiley   +1 more source

The Lupus Damage Index Revision Program: Results From the Item Generation and Reduction Phases

Arthritis Care &Research, EarlyView.
Objective A data‐driven and expert/patient consensus‐based project to develop a revised Systemic Lupus International Collaborating Clinics (SLICC)/American College of Rheumatology (ACR) Damage Index (SDI) is under way supported by SLICC, ACR, and the Lupus Foundation of America. Our objective is to report the item generation and reduction phase results
Burak Kundakci, Megan R. W. Barber, Ann E. Clarke, Sindhu R. Johnson, Anselm Mak, Hermine I. Brunner, Murat Inanc, Rosalind Ramsey‐Goldman, Guillermo Ruiz‐Irastorza, Ellen M. Ginzler, John G. Hanly, Alexandra Legge, Cynthia Aranow, Laurent Arnaud, Nathalie Costedoat‐Chalumeau, Dafna D. Gladman, Søren Jacobsen, Michelle Petri, Clovis A. Silva, Évelyne Vinet, Alexandre E. Voskuyl, SDI Revision Literature Review Groups, SDI Revision Delphi Panel, SDI Revision Item Reduction Committee, SDI Revision Clinical Domain Groups, Ian N. Bruce   +25 more
wiley   +1 more source

Young Star Clusters Dominate the Production of Detached Black Hole–Star Binaries

The Astrophysical Journal
The recent discovery of two detached black hole–star (BH–star) binaries from Gaia’s third data release has sparked interest in understanding the formation mechanisms of these systems.
Ugo Niccolò Di Carlo, Poojan Agrawal, Carl L. Rodriguez, Katelyn Breivik   +3 more
doaj   +1 more source

Air‐Pressure–Actuated Vibroacoustic Metamaterial With Tunable Bandgap: Design, Modeling, and Characterization

Advanced Engineering Materials, EarlyView.
This article presents the design, modeling, and characterization of air‐pressure–actuated programmable vibroacoustic metamaterials (PVAMM). The study focuses on leveraging air pressure to dynamically tune resonance frequencies for effective noise attenuation.
William Kaal, Michael M. Becker, Sarah C. L. Fischer   +2 more
wiley   +1 more source

A 16 Myr Super-Neptune in Upper Centaurus Lupus and a Preliminary Survey of Transiting Planets in Sco-Cen with TESS

The Astronomical Journal
Measuring the properties of planets younger than about 50 Myr helps to test different planetary formation and evolution models. NASA’s Transiting Exoplanet Survey Satellite (TESS) has observed nearly the entire sky, including a wide range of star-forming
Sydney Vach, George Zhou, Andrew W. Mann, Madyson G. Barber, Tyler R. Fairnington, Chelsea X. Huang, James G. Rogers, Luke G. Bouma, Joachim Krüger, Duncan Wright, Annabelle E. Niblett, Jack M. Nelson, Samuel N. Quinn, David W. Latham, Allyson Bieryla, Karen A. Collins, Michelle Kunimoto, Cristilyn N. Watkins, Richard P. Schwarz, Kevin I. Collins, Ramotholo Sefako, Keith Horne, Steve B. Howell, Catherine A. Clark, Colin Littlefield, Jessie L. Christiansen, Zahra Essack, Joshua N. Winn   +27 more
doaj   +1 more source