Results 31 to 40 of about 419,255 (408)

Skeletal Biology and Disease Modeling in Zebrafish

Journal of Bone and Mineral Research, 2021
Zebrafish are teleosts (bony fish) that share with mammals a common ancestor belonging to the phylum Osteichthyes, from which their endoskeletal systems have been inherited.
Kristin Dietrich, I. Fiedler, A. Kurzyukova, Alejandra C. López-Delgado, Lucy M McGowan, Karina Geurtzen, Chrissy L Hammond, B. Busse, F. Knopf   +8 more
semanticscholar   +1 more source

Development of a Zebrafish Sepsis Model for High-Throughput Drug Discovery

Molecular Medicine, 2017
Sepsis is a leading cause of death worldwide. Current treatment modalities remain largely supportive. Intervention strategies focused on inhibiting specific mediators of the inflammatory host response have been largely unsuccessful, a consequence of an ...
Anju M. Philip, Youdong Wang, Antonio Mauro, Suzan El-Rass, John C. Marshall, Warren L. Lee, Arthur S. Slutsky, Claudia C. dos Santos, Xiao-Yan Wen   +8 more
doaj   +1 more source

Myocardial protective effect and transcriptome profiling of Naoxintong on cardiomyopathy in zebrafish

Chinese Medicine, 2021
Background Cardiomyopathy is a kind of cardiovascular diseases, which makes it more difficult for the heart to pump blood to other parts of the body, eventually leading to heart failure.
Mengyan Hu, Peirong Liu, Shuxian Lu, Zhihao Wang, Zhaojie Lyu, Hongkai Liu, Yuhong Sun, Feng Liu, Jing Tian   +8 more
doaj   +1 more source

Zebrafish as a tractable model of human cardiovascular disease

British Journal of Pharmacology, 2021
Mammalian models including non‐human primates, pigs and rodents have been used extensively to study the mechanisms of cardiovascular disease. However, there is an increasing desire for alternative model systems that provide excellent scientific value ...
George Bowley, E. Kugler, Rob Wilkinson, A. Lawrie, F. V. van Eeden, T. Chico, P. Evans, E. Noël, J. Serbanovic-Canic   +8 more
semanticscholar   +1 more source

The zebrafish reference genome sequence and its relationship to the human genome

Nature, 2013
Zebrafish have become a popular organism for the study of vertebrate gene function. The virtually transparent embryos of this species, and the ability to accelerate genetic studies by gene knockdown or overexpression, have led to the widespread use of ...
K. Howe, M. Clark, C. Torroja, J. Torrance, Camille Berthelot, Matthieu Muffato, J. Collins, S. Humphray, K. McLaren, L. Matthews, Stuart Mclaren, I. Sealy, M. Cáccamo, C. Churcher, C. Scott, J. Barrett, Romke Koch, Gerd-Jörg Rauch, S. White, W. Chow, Britt Kilian, Leonor T. Quintais, J. A. Guerra-Assunção, Yi Zhou, Yong Gu, J. Yen, J. Vogel, T. Eyre, S. Redmond, R. Banerjee, J. Chi, B. Fu, E. Langley, Sean F. Maguire, G. Laird, D. Lloyd, E. Kenyon, S. Donaldson, H. Sehra, J. Almeida-King, J. Loveland, S. Trevanion, Matt Jones, M. Quail, D. Willey, A. Hunt, J. Burton, S. Sims, K. McLay, Bob Plumb, Joy L. Davis, C. Clee, K. Oliver, R. Clark, C. Riddle, David Elliott, Glen Threadgold, G. Harden, D. Ware, Sharmin Begum, B. Mortimore, G. Kerry, P. Heath, B. Phillimore, A. Tracey, N. Corby, M. Dunn, Christopher N. Johnson, J. Wood, S. Clark, S. Pelan, G. Griffiths, Michelle Smith, R. Glithero, Philip Howden, Nicholas F. Barker, C. Lloyd, Christopher Stevens, J. Harley, K. Holt, G. Panagiotidis, J. Lovell, H. Beasley, C. Henderson, D. Gordon, Katherine Auger, Deborah Wright, Joanna Collins, C. Raisen, L. Dyer, Kenric Leung, Lauren Robertson, K. Ambridge, D. Leongamornlert, Sarah McGuire, Ruth Gilderthorp, C. Griffiths, Deepa Manthravadi, S. Nichol, G. Barker, S. Whitehead, M. Kay, Jacqueline Brown, Clare Murnane, Emma V. Gray, M. Humphries, N. Sycamore, Darren Barker, D. Saunders, J. Wallis, A. Babbage, S. Hammond, M. Mashreghi-mohammadi, Lucy Barr, Sancha Martin, P. Wray, A. Ellington, N. Matthews, M. Ellwood, Rebecca Woodmansey, G. Clark, James D. Cooper, A. Tromans, D. Grafham, C. Skuce, R. Pandian, R. Andrews, Elliot Harrison, A. Kimberley, J. Garnett, Nigel Fosker, R. Hall, P. Garner, Daniel Kelly, C. Bird, S. Palmer, Ines Gehring, A. Berger, Christopher M. Dooley, Zübeyde Ersan-Ürün, C. Eser, Horst Geiger, Maria Geisler, Lena Karotki, A. Kirn, Judith Konantz, M. Konantz, M. Oberländer, Silke Rudolph-Geiger, Mathias Teucke, C. Lanz, G. Raddatz, K. Osoegawa, B. Zhu, A. Rapp, S. Widaa, C. Langford, Fengtang Yang, S. Schuster, N. Carter, J. Harrow, Z. Ning, Javier Herrero, S. Searle, Anton J. Enright, R. Geisler, R. Plasterk, Charles Lee, M. Westerfield, P. Jong, L. Zon, J. Postlethwait, C. Nüsslein-Volhard, T. Hubbard, H. R. Crollius, J. Rogers, D. Stemple   +176 more
semanticscholar   +1 more source

Macrophages directly contribute collagen to scar formation during zebrafish heart regeneration and mouse heart repair

Nature Communications, 2020
Canonical roles for macrophages in mediating the fibrotic response after a heart attack include extracellular matrix turnover and activation of cardiac fibroblasts to initiate collagen deposition.
Filipa C. Simões, T. Cahill, Amy Kenyon, Daria Gavriouchkina, J. Vieira, Xin Sun, D. Pezzolla, Christophe Ravaud, Eva Masmanian, Michael Weinberger, Sarah Mayes, M. Lemieux, Damien N. Barnette, M. Gunadasa-Rohling, Ruth M. Williams, D. Greaves, Le A. Trinh, S. Fraser, S. Dallas, R. Choudhury, T. Sauka-Spengler, P. Riley   +21 more
semanticscholar   +1 more source

Zebrafish in oncology

Aging, 2013
Novel high-throughput technologies generate an unprecedented amount of data, which present a challenge for oncologists aiming to provide personalized treatment. Progress in genetic engineering and xenotransplantation in conjunction with live imaging could establish the zebrafish as one of the most versatile animal models for cancer research.
Barriuso, Jorge, Nagaraju, Raghavendar, Hurlstone, Adam   +2 more
openaire   +3 more sources

Mapping the m1A, m5C, m6A and m7G methylation atlas in zebrafish brain under hypoxic conditions by MeRIP-seq

BMC Genomics, 2022
Background The epigenetic modifications play important regulatory roles in tissue development, maintenance of physiological functions and pathological process.
Wei Li, Xiaoyu Li, Xunjie Ma, Wei Xiao, Jingjing Zhang   +4 more
doaj   +1 more source

Zebrafish in Inflammasome Research [PDF]

Cells, 2019
Inflammasomes are cytosolic multiprotein complexes that regulate inflammatory responses to danger stimuli and infection, and their dysregulation is associated with an increasing number of autoinflammatory diseases. In recent years, zebrafish models of human pathologies to study inflammasome function in vivo have started to emerge.
Gabriel Forn-Cuní, Annemarie H. Meijer, Monica Varela   +2 more
openaire   +5 more sources

Claudin-5a is essential for the functional formation of both zebrafish blood-brain barrier and blood-cerebrospinal fluid barrier

Fluids and Barriers of the CNS, 2022
Background Mammalian Claudin-5 is the main endothelial tight junction component maintaining blood-brain barrier (BBB) permeability, while Claudin-1 and -3 seal the paracellular space of choroid plexus (CP) epithelial cells contributing to the blood ...
Yanyu Li, Chunchun Wang, Liang Zhang, Bing Chen, Yuqian Mo, Jingjing Zhang   +5 more
doaj   +1 more source