Results 41 to 50 of about 124,032 (187)

Expanding Genetic Code to Generate Human Brain Organoids with Both Vasculature and Microglia‐Like Cells

Advanced Science, EarlyView.
Using genetic code expansion, we engineered vascularized human cerebral organoids (vhCOs) with microglia‐like cells and blood‐brain barrier features. vhCOs recapitulate neurovascular interactions, regional identities, and neuronal subtypes resembling the fetal brain.
Haishuang Lin, Yaqing Wang, Hu Du, Yuxin Qin, Haoyu Zhang, Peng Wang, Lin Wei, Jianhua Qin   +7 more
wiley   +1 more source

ZIKA VÍRUS ASSOCIADO À MICROCEFALIA [PDF]

, 2016
O Zika vírus (ZIKV) é um emergente flavivírus transmitido por mosquitos do gênero Aedes. Incialmente foi isolado de um macaco Rhesus utilizado para monitoramento da febre amarela na floresta Zika, localizada na Uganda em 1947.
Tomal, Nayara Rubia
core  

Composto com propriedades antivirais contra vírus zika

, 2023
BR 10 2021 014737-7A presente patente de invenção trata de composto com propriedades antivirais contra vírus Zika onde, notadamente, a molécula de origem sintética é composta pelo peptídeo de sequência FALALKALKKALKKL-COOH conjugado com o composto ...
Lima, Maria Leticia Duarte, Calmon, Marilia de Freitas, Sanches, Paulo Ricardo da Silva, Carneiro, Bruno Moreira, Rahal, Paula, Oliva, Cintia Bittar, Ayusso, Gabriela Miranda, Cilli, Eduardo Maffud, Batista, Mariana Nogueira   +8 more
core  

Lyssavirus Nucleoprotein Induces GPAT4‐Mediated CYB5R1 Depalmitoylation to Suppress Ferroptosis and Promote Viral Replication

Advanced Science, EarlyView.
Lipid metabolism plays a vital role in viral infections. Here, we reveal that the lyssavirus N protein regulates GPAT4 to induce lipid droplet biogenesis, restricting CYB5R1 palmitoylation and reducing ferroptosis susceptibility to ultimately promote viral replication.
Jianqing Zhao, Chuan Liang, Pingping Chen, Meixin Sun, Zhen F. Fu, Ling Zhao, Ming Zhou   +6 more
wiley   +1 more source

Zika Virus Infection, Basic and Clinical Aspects: A Review Article

Iranian Journal of Public Health, 2019
Background: Zika virus infection has recently attracted the attention of medical community. While clinical manifestations of the infection in adult cases are not severe and disease is not associated with high mortality rates, Zika virus infection can ...
Farshid NOORBAKHSH, Kamal ABDOLMOHAMMADI, Yousef FATAHI, Hossein DALILI, Mehrnaz RASOOLINEJAD, Farshid REZAEI, Mostafa SALEHI-VAZIRI, Nazanin Zahra SHAFIEI-JANDAGHI, Ehsan Shamsi GOOSHKI, Morteza ZAIM, Mohammad Hossein NICKNAM   +10 more
doaj   +1 more source

Bridging the translational gap in clinical nanomedicine: From rational design to clinical reality

BMEMat, EarlyView.
Nanotechnology offers a multi‐faceted approach to modern healthcare, encompassing high‐sensitivity diagnostic imaging, innovative vaccine delivery, and targeted therapeutics. This review explores how these nanomedicine applications address critical challenges in cancer recurrence and the treatment of neurologic and respiratory diseases to combat rising
Ahmed H. Ghonaim, Marwa Ahmed El‐Naka, Wedad M. Nageeb, Atta Ullah Khan, Noura M. Seleem, Aliaa Abdelghafar, Doaa Zamel, Yang Liu, Qigai He, Wentao Li   +9 more
wiley   +1 more source

Characteristics of Reported Symptoms Among Confirmed and Suspect Cases of Zika Virus in Georgia, 2016

Journal of the Georgia Public Health Association, 2017
Background: In May 2015, Zika virus was detected in Brazil. The virus has since spread through several countries in the Americas. Knowledge of the major symptoms of Zika virus infection was based on historic data from two previous outbreaks in the ...
Ashton Thompson
doaj   +1 more source

KNOWLEDGE AND PRACTICES OF MIDWIVES REGARDING ZIKA VIRUS IN KENDARI, SOUTHEAST SULAWESI, INDONESIA

Public Health of Indonesia, 2020
Background: In 2016 Zika virus infection became an international public health emergency concern. Objective: This study aimed to evaluate the knowledge and practice of midwives regarding the Zika virus.
Ramadhan Tosepu, Indri Eka Artamevia Khaerun Nisa Patawari, Hariati Lestari, Siti Rabbani Karimuna, La Ode Muhamad Sety, Fifi Nirmala   +5 more
doaj   +1 more source

OXCT1‐driven succinylation of PSMG3 stabilizes the proteasome to facilitate picornavirus replication

iMetaOmics, EarlyView.
Upon entering the pig, foot‐and‐mouth disease virus (FMDV) regulates host glycolysis and the citrate cycle by modulating the expression of metabolic enzymes, resulting in changes in post‐translational modifications (PTMs) including succinylation, lactylation, crotonylation, acetylation, and phosphorylation.
Huisheng Liu, Qiao Xue, Pengfei Liu, Zhihua Dong, Weijun Cao, Fan Yang, Yingming Zhu, Lei Deng, Zixiang Zhu, Haixue Zheng   +9 more
wiley   +1 more source

Government as orchestrator: Ecosystem transformation at scale and speed

Strategic Management Journal, EarlyView.
Abstract Research Summary Grand challenges are ecosystem challenges: success depends on aligning a multilateral set of public and private sector actors whose interdependent contributions determine whether a mission is achieved. This study examines how government can orchestrate ecosystem alignment by leveraging distinctive capabilities to deliver ...
Ron Adner
wiley   +1 more source