Results 51 to 60 of about 53,360 (205)

DMS‐MaPseq and DREEM Analyses Implicate the Critical Role of RNA Structural Dynamics in Turnip Yellow Mosaic Virus Pathogenicity

Advanced Science, EarlyView.
RNA structural profiling of Turnip Yellow Mosaic Virus by DMS‐MaPseq and DREEM analyses uncover that viral genome‐wide RSS is highly complicated and heterogeneous, with alternative RSSs widely distributed across the genome. Notably, the viral 3’ tRNA‐like structure adopts alternative conformations in vivo.
Jiaying Zhu, Changhao Li, Chisimbily Onyia, Xindi Li, Xingxing Yan, Songxiao Zhong, Taerin Oh, Xiuren Zhang   +7 more
wiley   +1 more source

Zika Virus Infection, Basic and Clinical Aspects: A Review Article

Iranian Journal of Public Health, 2019
Background: Zika virus infection has recently attracted the attention of medical community. While clinical manifestations of the infection in adult cases are not severe and disease is not associated with high mortality rates, Zika virus infection can ...
Farshid NOORBAKHSH, Kamal ABDOLMOHAMMADI, Yousef FATAHI, Hossein DALILI, Mehrnaz RASOOLINEJAD, Farshid REZAEI, Mostafa SALEHI-VAZIRI, Nazanin Zahra SHAFIEI-JANDAGHI, Ehsan Shamsi GOOSHKI, Morteza ZAIM, Mohammad Hossein NICKNAM   +10 more
doaj   +1 more source

Maternal Zika Virus Infection in the First Trimester and Fetal Stigmata in the Third Trimester

Indian Journal of Radiology and Imaging, 2023
Zika is a flavivirus that is transmitted primarily by the bite of an infected Aedes mosquito. It can also be transmitted by blood transfusion, sexual contact, and from an infected mother to the unborn baby.
Divya Singh, Ladbans Kaur
doaj   +1 more source

Crianças com microcefalia pelo vírus Zika: delineamento e avaliação das alterações sensoriais [PDF]

, 2023
The aim was to identify the main sensory alterations in children with microcephaly caused by the Zika virus and the influence of care overload, using the Burden Interview scale. A cross-sectional study with a quantitative approach.
Rego Filho, Jeronimo Faustino do, Sena, Cláudia Alves de, Wajnsztejn, Rubens   +2 more
core   +2 more sources

Humanized immune system animal models and their recent applications

Animal Models and Experimental Medicine, EarlyView.
In this review, we provide an updated and comprehensive overview of the current state of humanized immune system animal model research. We discuss the variety of techniques used to produce humanized mice with their respective strengths and weaknesses, and evaluate the advantages and limitations of these models, including issues with incomplete immune ...
Nicolas Skuli, Rudra B. Amin, A’ishah Bakayoko, Marisa Kruidenier, Sahara Aqui, Sarah J. Skuli, Terence P. Gade   +6 more
wiley   +1 more source

Insecticide susceptibility of Aedes albopictus and Ae. aegypti from Brazil and the Swiss-Italian border region [PDF]

, 2017
Aedes aegypti and Ae. albopictus are two highly invasive mosquito species, both vectors of several viruses, including dengue, chikungunya and Zika. While Ae. aegypti is the primary vector in the tropics and sub-tropics, Ae.
Araújo, Ana Paula, Ayres, Constância Flávia Junqueira, Barbosa, Rosângela Maria Rodrigues, Crespo, Mônica Maria, de Melo-Santos, Maria Alice Varjal, de Oliveira, Cláudia Maria Fontes, de Oliveira, Mariana Francelino, de Oliveira, Thaynan Sama Alves, Engeler, Lukas, Flacio, Eleonora, Müller, Pie, Regis, Lêda Narcisa, Silva-Filha, Maria Helena Neves Lobo, Suter, Tobias   +13 more
core   +1 more source

ProTides for Antiviral Activity Beyond Liver Cells

Chemistry – A European Journal, EarlyView.
A strategy for obtaining prodrugs of antiviral nucleotides with broad tissue activity is presented that relies on cycloalkyl or cycloalkylalkyl esters, improving uptake and esterase cleavage, and producing nanomolar inhibitors in kidney, colon, and lung cells.
Felix Goebel, Adrian Humboldt, Heeyoung Kim, Carl J. M. Schölzel, Ralf Bartenschlager, Clemens Richert   +5 more
wiley   +1 more source

Zika Virus RNA Replication and Persistence in Brain and Placental Tissue

Emerging Infectious Diseases, 2017
Zika virus is causally linked with congenital microcephaly and may be associated with pregnancy loss. However, the mechanisms of Zika virus intrauterine transmission and replication and its tropism and persistence in tissues are poorly understood.
Julu Bhatnagar, Demi B. Rabeneck, Roosecelis B. Martines, Sarah Reagan-Steiner, Yokabed Ermias, Lindsey B.C. Estetter, Tadaki Suzuki, Jana M. Ritter, M. Kelly Keating, Gillian Hale, Joy Gary, Atis Muehlenbachs, Amy J. Lambert, Robert Lanciotti, Titilope Oduyebo, Dana Meaney-Delman, Fernando Bolaños, Edgar Alberto Parra Saad, Wun-Ju Shieh, Sherif Zaki   +19 more
doaj   +1 more source

Maltase 1 regulates DENV2 infection and life history in Aedes aegypti

Insect Science, EarlyView.
Our study employed CRISPR/Cas9 to generate a MAL1 knockout strain of Aedes aegypti, demonstrating that the absence of MAL1 significantly suppresses DENV2 replication in the midgut and impairs viral transmission. The mutation also altered life‐history (hatching/pupation/emerging rates and sex‐specific survival), identifying MAL1 as a novel target for ...
Man‐Jin Li, Jin Cheng, Ya‐Ming Zou, Quan‐Chao Liu, Ding Zhu, Ce‐Jie Lan   +5 more
wiley   +1 more source

Cleft analysis of Zika virus non-structural protein 1

Asian Pacific Journal of Tropical Biomedicine, 2017
The non-structural protein 1 is an important molecule of the viruses in flavivirus group including to Zika virus. Recently, the NS1 of Zika virus was discovered.
Somsri Wiwanitkit, Viroj Wiwanitkit
doaj   +1 more source