Results 61 to 70 of about 105,660 (261)

Zika virus infection reprograms global transcription of host cells to allow sustained infection. [PDF]

, 2017
Zika virus (ZIKV) is an emerging virus causally linked to neurological disorders, including congenital microcephaly and Guillain-Barré syndrome. There are currently no targeted therapies for ZIKV infection.
Bansal, Vikas, Dang, Jason, Lichinchi, Gianluigi, Qin, Yue, Rana, Tariq M, Tiwari, Shashi Kant   +5 more
core   +2 more sources

Characterization of Zika virus endocytic pathways in human glioblastoma cells [PDF]

, 2020
Zika virus (ZIKV) infections can cause microcephaly and neurological disorders. However, the early infection events of ZIKV in neural cells remain to be characterized. Here, by using a combination of pharmacological and molecular approaches and the human
Du, T, Fu, M, Griffin, GE, Hu, Q, Li, C, Li, M, Liu, Y, Ni, F, Wang, H, Zhang, D, Zhang, M, Zheng, Z   +11 more
core   +1 more source

Membrane Fusion‐Inspired Nanomaterials: Emerging Strategies for Infectious Disease and Cancer Diagnostics

Advanced Healthcare Materials, EarlyView.
Membrane fusion‐inspired nanomaterials offer transformative potential in diagnostics by mimicking natural fusion processes to achieve highly sensitive and specific detection of disease biomarkers. This review highlights recent advancements in nanomaterial functionalization strategies, signal amplification systems, and stimuli‐responsive fusion designs,
Sojeong Lee, Khulan Nyamzaya, Jueun Han, Yejin Song, Jihee Lee, Jung Hyun Jo, Seungmin Bang, Eun‐Kyung Lim, Seungjoo Haam, Eunjung Kim   +9 more
wiley   +1 more source

The Zika Virus Threat: How Concerns About Scientists May Undermine Efforts to Combat the Pandemic [PDF]

, 2017
Using data from the University of New Hampshire’s October 2016 Granite State Poll, authors Thomas Safford, Lawrence Hamilton, and Emily Whitmore investigate how New Hampshire residents view the Zika crisis.
Hamilton, Lawrence C., Safford, Thomas G., Whitmore, Emily   +2 more
core   +2 more sources

Specific detection of dengue and Zika virus antibodies using envelope proteins with mutations in the conserved fusion loop [PDF]

, 2017
Detection of antibodies is widely used for the diagnosis of infections with arthropod-borne flaviviruses including dengue (DENV) and Zika virus (ZIKV). Due to the emergence of ZIKV in areas endemic for DENV, massive co-circulation is observed and methods
Barzon, Luisa, Brites, Carlos, Drexler, Jan Felix, Ferreira, Orlando C, Kumbukgolla, Widuranga, Moges, Beyene, Moreira-Soto, Andres, Pal\uf9, Giorgio, Rockstroh, Alexandra, Sarno, Manoel, Schmidt-Chanasit, Jonas, Sinigaglia, Alessandro, Ulbert, Sebastian   +12 more
core   +2 more sources

Identification and Characterization of an In Silico Designed Membrane‐Active Peptide with Antiviral Properties

Advanced Science, EarlyView.
An evolutionary molecular dynamics platform is used to design P1.6, a membrane‐active peptide that senses lipid packing defects in viral envelopes. P1.6 adopts a stabilized α‐helical structure upon membrane contact, disrupts virus‐like liposomes, and damages HIV‐1 particles.
Pascal von Maltitz, Niek van Hilten, Tatjana Weil, Thunchanok Thummaraj, Jeroen Methorst, Dennis Aschmann, Alexander Kros, Clarissa Read, Jasmina Gačanin, Herre Jelger Risselada, Jan Münch   +10 more
wiley   +1 more source

A neonatal nonhuman primate model of gestational Zika virus infection with evidence of microencephaly, seizures and cardiomyopathy.

PLoS ONE, 2020
Zika virus infection during pregnancy is associated with miscarriage and with a broad spectrum of fetal and neonatal developmental abnormalities collectively known as congenital Zika syndrome (CZS). Symptomology of CZS includes malformations of the brain
Rosemary J Steinbach, Nicole N Haese, Jessica L Smith, Lois M A Colgin, Rhonda P MacAllister, Justin M Greene, Christopher J Parkins, J Beth Kempton, Edward Porsov, Xiaojie Wang, Lauren M Renner, Trevor J McGill, Brandy L Dozier, Craig N Kreklywich, Takeshi F Andoh, Marjorie R Grafe, Heidi L Pecoraro, Travis Hodge, Robert M Friedman, Lisa A Houser, Terry K Morgan, Peter Stenzel, Jonathan R Lindner, Robert L Schelonka, Jonah B Sacha, Victoria H J Roberts, Martha Neuringer, John V Brigande, Christopher D Kroenke, Antonio E Frias, Anne D Lewis, Meredith A Kelleher, Alec J Hirsch, Daniel Neal Streblow   +33 more
doaj   +1 more source

Identifiying High Risk Areas of Zika Virus Infection by Meteorological Factors in Columbia [PDF]

, 2019
Background Several Zika virus (ZIKV) outbreaks have occurred since October 2015. Because there is no effective treatment for ZIKV infection, developing an effective surveillance and warning system is currently a high priority to prevent ZIKV infection ...
Chien, Lung-Chang, Perez, Adriana, Sy, Francisco   +2 more
core   +2 more sources

Caspase‐3/GSDME‐Mediated Trophoblast Pyroptosis and Reciprocal Macrophage Polarization Contribute to Inflammation in Early‐Onset Preeclampsia

Advanced Science, EarlyView.
In trophoblast cells, T/S (TNFα + SM164) activated caspase‐3, which cleaved GSDME to switch apoptosis to pyroptosis, causing cell swelling, membrane rupture, and release of LDH, HMGB1, IL‐1β and IL‐18. These cytokines induced pro‐inflammatory macrophage polarization, which in turn reinforced pyroptotic signaling in trophoblasts, amplifying systemic ...
Baoying Huang, Weinan Deng, Shilei Bi, Yifan Wang, Zhaowei Tu, Lijun Huang, Lili Du, Lizi Zhang, Zhoushan Feng, Wei Sun, Tengfei Liu, Julia Kzhyshkowska, Haibin Wang, Jingsi Chen, Dunjin Chen, Shuang Zhang   +15 more
wiley   +1 more source

Risk of Zika virus transmission by blood donations in Brazil

Hematology, Transfusion and Cell Therapy, 2018
Background: Zika, a disease caused by Zika virus infections, has recently emerged and caused outbreaks in many parts of the world. The clinical manifestations of Zika are usually mild, mostly presenting as an exanthematic febrile disease, but on some ...
Mariana Munari Magnus, Danillo Lucas Alves Espósito, Victor Antonio da Costa, Priscila Silva de Melo, Carolina Costa-Lima, Benedito Antonio Lopes da Fonseca, Marcelo Addas-Carvalho   +6 more
doaj   +1 more source