Results 51 to 60 of about 2,063,842 (302)

3D Macroporous Zinc Compound/Silicone Hybrid Foams for Amperometric Sensing of Glucose Oxidase

Global Challenges, 2019
A 3D porous matrix makes an intriguing sensing platform, which can integrate functional guest molecules. Here, the first demonstration of a zinc compound/silicone hybrid foam is reported for amperometric sensing of glucose oxidase.
Ye Wu, Hao Fu, Weiwei Xie, Yingcheng Lin, Orhan Kizilkaya, Jian Xu   +5 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

BIOLOGICAL ROLE OF ZINC AND ITS COMPOUNDS

Bulletin of the National Technical University "KhPI". Series: Innovation researches in students’ scientific work
The presented data indicate that the biological role of zinc in the body is largely mediated through its involvement in the synthesis and stabilization of nucleic acids and proteins, energy metabolism, cellular proliferation and differentiation, and the maintenance of antioxidant status.
Ganna Syrova, Nataliia Chalenko, Svitlana Kozub   +2 more
openaire   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Experimental evaluation of acute toxicity heterometalic new compounds – tartratogermanat cooper and zinc

Zaporožskij Medicinskij Žurnal, 2017
One of the possible ways of creating new drugs is aiming synthesis of compounds previously envisaged activity. Perspective in this area is to obtain complexes based on metal ions and ligands.
G. P. Paniotova, P. B. Antonenko, V. V. Godovan, I. I. Seifullina, O. A. Chebanenko, K. H. Lobashova   +5 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Structural Characterization of TRAF6 N-Terminal for Therapeutic Uses and Computational Studies on New Derivatives

Pharmaceuticals, 2023
Tumor necrosis factor receptor-associated factors (TRAFs) are a protein family with a wide variety of roles and binding partners. Among them, TRAF6, a ubiquitin ligase, possesses unique receptor binding specificity and shows diverse functions in immune ...
Omur Guven, Belgin Sever, Faika Başoğlu-Ünal, Abdulilah Ece, Hiroshi Tateishi, Ryoko Koga, Mohamed O. Radwan, Nefise Demir, Mustafa Can, Mutlu Dilsiz Aytemir, Jun-ichiro Inoue, Masami Otsuka, Mikako Fujita, Halilibrahim Ciftci, Hasan DeMirci   +14 more
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Dynamic Shear Deformation in Zinc Crystals [PDF]

, 1962
The initial stages of yielding in single crystals of zinc have been investigated at temperatures of -292°F (-180°C), -93°F (-70°C) and +75°F (24°C), by means of rapidly applied constant stress pulses to produce slip along the basal planes of these ...
King, Kenneth Robert
core   +1 more source